The Pathology of Intestinal Mucosal Disruption; Implications for Muscle Loss and Physical Dependency from Late Adolescence to Octogenarians DOI Creative Commons
Rizwan Qaisar, Asima Karim, M. Shahid Iqbal

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 6117 - 6126

Published: Dec. 1, 2024

Background and Objectives: A pathological increase in intestinal permeability causes muscle loss physical decline by inducing systemic inflammation oxidative stress. However, most relevant studies investigate older adults, the appropriate data across age spans remain elusive. This study aimed to examine associations of with a large span ages. We measured plasma zonulin, marker increased permeability, from adolescents octogenarians association health gait speed. Research Methods Procedures: In this cross-sectional, observational study, we recruited healthy men, including young (age=18-35 years, n=135), middle-aged (age=35-59 n=118), (age=60-90 n=163) adults for evaluating - handgrip strength (HGS), skeletal mass index (SMI), also c-reactive proteins (CRP), 8—isoprostanes using ELISA assays. Results: Plasma zonulin gradually (all p< 0.05). Conversely, HGS speed were progressively reduced addition, exhibited lower SMI than men (both significant negative correlations positive CRP 8-isoprostanes found areas under curve efficacy diagnosing low (< 27kg) (0.8 m/s). After adjustment age, demonstrated robust cumulative cohort. Conclusion: Altogether, an increasing leak middle onward contributes weakness decline. Our is clinically understanding treating dependency adults. Keywords: Handgrip strength,

Language: Английский

The improvement in muscle function following statin withdrawal might involve the repair of the neuromuscular junction DOI
Rizwan Qaisar, Asima Karim, Shaea Alkahtani

et al.

British Journal of Clinical Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Aims The effects and relative mechanisms of statin usage withdrawal on subjective objective muscle functions are poorly known. We investigated the associations neuromuscular junction (NMJ) degradation to impairment in older adults taking statins. Methods recruited male controls ( n = 82) users 76) for measuring handgrip strength (HGS), body composition, gait speed, short physical performance battery (SPPB), statin‐associated symptoms (SAMS) plasma c‐terminal agrin fragment‐22 (CAF22; a marker NMJ degradation). were evaluated at baseline, 1 year after 6 months withdrawal. Results One was associated with lower HGS, SPPB scores higher SAMS CAF22 levels (all P < .05). Conversely, withdrawal, speed restored concurrent reduction Correlation analysis revealed significant correlations Lastly, also reduced creatine kinase Conclusion Altogether, decline an increase SAMS, which partly Our findings suggest role plasticity restoration following

Language: Английский

Citations

0
The Pathology of Intestinal Mucosal Disruption; Implications for Muscle Loss and Physical Dependency from Late Adolescence to Octogenarians DOI Creative Commons
Rizwan Qaisar, Asima Karim, M. Shahid Iqbal

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 6117 - 6126

Published: Dec. 1, 2024

Background and Objectives: A pathological increase in intestinal permeability causes muscle loss physical decline by inducing systemic inflammation oxidative stress. However, most relevant studies investigate older adults, the appropriate data across age spans remain elusive. This study aimed to examine associations of with a large span ages. We measured plasma zonulin, marker increased permeability, from adolescents octogenarians association health gait speed. Research Methods Procedures: In this cross-sectional, observational study, we recruited healthy men, including young (age=18-35 years, n=135), middle-aged (age=35-59 n=118), (age=60-90 n=163) adults for evaluating - handgrip strength (HGS), skeletal mass index (SMI), also c-reactive proteins (CRP), 8—isoprostanes using ELISA assays. Results: Plasma zonulin gradually (all p< 0.05). Conversely, HGS speed were progressively reduced addition, exhibited lower SMI than men (both significant negative correlations positive CRP 8-isoprostanes found areas under curve efficacy diagnosing low (< 27kg) (0.8 m/s). After adjustment age, demonstrated robust cumulative cohort. Conclusion: Altogether, an increasing leak middle onward contributes weakness decline. Our is clinically understanding treating dependency adults. Keywords: Handgrip strength,

Language: Английский

Citations

0