Biomolecules,
Journal Year:
2024,
Volume and Issue:
15(1), P. 4 - 4
Published: Dec. 24, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
prevalent
metabolic
disorder
with
an
increased
risk
for
cardiovascular
disease
(CVD)
that
enhanced
by
obesity.
This
study
sought
to
determine
whether
panel
of
proteins
(CVRPs)
would
be
dysregulated
in
overweight/obese
PCOS
patients,
highlighting
potential
biomarkers
CVD
PCOS.
In
this
exploratory
cross-sectional
study,
plasma
levels
54
CVRPs
were
analyzed
women
(n
=
147)
and
controls
97).
measured
using
the
SOMAscan
proteomic
platform
(version
3.1),
significant
identified
through
linear
models,
regression
analysis,
receiver
operating
characteristic
(ROC)
analysis.
Analysis
on
BMI-matched
subsets
cohort
undertaken.
Functional
enrichment
protein-protein
interaction
analyses
elucidated
pathways
involved.
Eleven
(whole
set,
without
matching
body
mass
index
(BMI)
or
insulin
resistance
(IR)):
leptin,
Interleukin-1
receptor
antagonist
protein
(IL-1Ra),
polymeric
immunoglobulin
(PIGR),
interleukin-18
(IL-18Ra),
C-C
motif
chemokine
3
(MIP-1a),
angiopoietin-1
(ANGPT1)
upregulated
whilst
advanced
glycosylation
end
product-specific
receptor,
soluble
(sRAGE),
bone
morphogenetic
6
(BMP6);
growth/differentiation
factor
2
(GDF2),
superoxide
dismutase
[Mn]
mitochondrial
(MnSOD),
SLAM
family
member
5
(SLAF5)
downregulated
versus
controls.
(overweight/obese,
BMI
≥
26
kg/m2)
subset
six
common
whole
set:
ANGPT1
IL-1Ra
upregulated;
sRAGE,
BMP6,
GDF2,
Mn-SOD
downregulated.
addition,
lymphotactin
(XCL1)
was
placenta
growth
(PIGF),
alpha-L-iduronidase
(IDUA),
(sTie-2)
macrophage
metalloelastase
(MMP12)
A
analysis
plus
(IR)-matched
revealed
only
upregulation
tissue
(TF)
renin
PCOS,
potentially
serving
as
combination
obesity-related
(ANGPT1/IL/1Ra/XCL1)
cardioprotective
(sRAGE/BMP6/Mn-SOD/GDF2)
may
contribute
CVD.
TF
observed
BMI-
IR-matched
limited
sample
subgroup
indicates
their
Medicina,
Journal Year:
2024,
Volume and Issue:
60(8), P. 1307 - 1307
Published: Aug. 13, 2024
:
Pre-eclampsia
(PE)
is
a
pregnancy-specific
condition
characterized
by
significant
health
risks
for
pregnant
women
worldwide
due
to
its
status
as
multi-organ
disorder.
High
blood
pressure
(hypertension)
with
or
without
proteinuria
usually
considered
an
initial
clinical
sign
of
PE.
The
pathogenesis
pre-eclampsia
highly
complex
and
likely
involves
multiple
factors,
including
poorly
developed
uterine
spiral
arterioles,
immunological
issues,
placental
ischemia
infarction,
genetic
abnormalities.
Inflammatory
cytokine
production,
regulated
gene
polymorphisms,
one
the
factors
contributing
development
present
study
aimed
assess
IL-6,
IL-1β,
Apo
B-100
polymorphism
evaluate
association
these
polymorphisms
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8739 - 8739
Published: Aug. 10, 2024
Gestational
trophoblastic
diseases
(GTDs)
encompass
a
spectrum
of
conditions
characterized
by
abnormal
cell
growth,
ranging
from
benign
molar
pregnancies
to
malignant
neoplasms.
This
systematic
review
explores
the
molecular
underpinnings
GTDs,
focusing
on
genetic
and
epigenetic
factors
that
influence
disease
progression
clinical
outcomes.
Based
71
studies
identified
through
search
selection
criteria,
key
findings
include
dysregulations
in
tumor
suppressor
genes
such
as
p53,
aberrant
apoptotic
pathways
involving
BCL-2
(B-cell
lymphoma),
altered
expression
growth
factor
receptors
microRNAs
(micro-ribose
nucleic
acid).
These
alterations
not
only
differentiate
normal
placental
development
but
also
contribute
their
behavior,
moles
potentially
forms.
The
synthesizes
insights
immunohistochemical
analyses
provide
comprehensive
understanding
GTD
pathogenesis
implications
for
personalized
care
strategies.
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(8)
Published: Aug. 27, 2024
CD93
was
recently
identified
as
a
promising
therapeutic
target
for
angiogenesis
blockade
in
various
tumors.
Herein,
we
aimed
to
investigate
the
expression
and
clinicopathological
significance
of
gastric
adenocarcinoma.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10653 - 10653
Published: Oct. 3, 2024
Preeclampsia
(PE)
is
a
complex
and
multifaceted
obstetric
syndrome
characterized
by
several
distinct
molecular
subtypes.
It
complicates
up
to
5%
of
pregnancies
significantly
contributes
maternal
newborn
morbidity,
thereby
diminishing
the
long-term
quality
life
for
affected
women.
Due
widespread
dissatisfaction
with
effectiveness
existing
approaches
assessing
PE
risk,
there
pressing
need
ongoing
research
identify
newer,
more
accurate
predictors.
This
study
aimed
investigate
early
changes
in
serum
proteome
associated
signaling
pathways.
The
levels
125
proteins
at
11-13
weeks
gestation
were
quantified
using
liquid
chromatography-multiple
reaction
monitoring
mass
spectrometry
(LC-MRM
MS)
BAK-125
kit.
Ten
emerged
as
potential
markers
PE:
Apolipoprotein
M
(APOM),
Complement
C1q
subcomponent
subunit
B
(C1QB),
Lysozyme
(LYZ),
Prothrombin
(F2),
Albumin
(ALB),
Zinc-alpha-2-glycoprotein
(AZGP1),
Tenascin-X
(TNXB),
Alpha-1-antitrypsin
(SERPINA1),
Attractin
(ATRN),
A-IV
(APOA4).
Notably,
nine
these
have
previously
been
prior
research,
underscoring
consistency
reliability
our
findings.
These
play
key
roles
critical
processes,
including
complement
coagulation
cascades,
platelet
activation,
insulin-like
growth
factor
To
improve
prediction
PE,
highly
effective
Support
Vector
Machine
(SVM)
model
was
developed,
analyzing
19
from
first
trimester.
achieved
an
area
under
curve
(AUC)
0.91,
87%
sensitivity
95%
specificity,
hazard
ratio
(HR)
13.5
(4.6-40.8)
p
<
0.001.
findings
demonstrate
that
protein-based
SVM
models
possess
higher
predictive
power
compared
routine
first-trimester
screening
test,
highlighting
their
superior
utility
detection
risk
stratification
PE.
High Blood Pressure & Cardiovascular Prevention,
Journal Year:
2024,
Volume and Issue:
31(6), P. 677 - 685
Published: Oct. 16, 2024
Despite
many
decades
of
research,
the
exact
etiology
pre-eclampsia
(PE)
remains
unknown.
Several
etiopathologies
have
been
suggested,
including
role
placental
microbiota.
However,
existence
microbiota
and
its
possible
contribution
to
pregnancy
complications,
particularly
PE
has
remained
controversial.
The
present
study
was
designed
identify
different
microbes
that
co-exist
placenta
women
with
early-
late-onset
PE.
Thirty
age-matched
normotensive
early-onset
as
well
pre-eclamptic
respectively,
were
recruited.
After
obtaining
an
informed
consent,
tissues
obtained
through
caesarian
section
sterile
standardized
clinical
procedures.
DNA
extracted
from
each
tissue
microbiome
analysis
conducted
using
a
targeted
16
S
reads
analyzed
bioinformatics.
There
significance
difference
between
blood
pressure
early-/late-onset
compared
controls,
respectively.
In
addition,
placencental
samples
classified
belonging
phyla,
Actinobacteria,
Firmicutes,
Bacteroidetes,
Proteobacteria,
Proteobacteria
dominated
by
classes
Pseudomonadales
Gammaproteobacteria
smaller
amounts
Actinobacteria
Bacteroidetes.
no
significant
bacterial
species
Further
found
correlation
or
results
demonstrate
low
biomass
species,
which
might
further
indicate
had
very
levels
bacteria
there
is
composition
Biomolecules,
Journal Year:
2024,
Volume and Issue:
15(1), P. 4 - 4
Published: Dec. 24, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
prevalent
metabolic
disorder
with
an
increased
risk
for
cardiovascular
disease
(CVD)
that
enhanced
by
obesity.
This
study
sought
to
determine
whether
panel
of
proteins
(CVRPs)
would
be
dysregulated
in
overweight/obese
PCOS
patients,
highlighting
potential
biomarkers
CVD
PCOS.
In
this
exploratory
cross-sectional
study,
plasma
levels
54
CVRPs
were
analyzed
women
(n
=
147)
and
controls
97).
measured
using
the
SOMAscan
proteomic
platform
(version
3.1),
significant
identified
through
linear
models,
regression
analysis,
receiver
operating
characteristic
(ROC)
analysis.
Analysis
on
BMI-matched
subsets
cohort
undertaken.
Functional
enrichment
protein-protein
interaction
analyses
elucidated
pathways
involved.
Eleven
(whole
set,
without
matching
body
mass
index
(BMI)
or
insulin
resistance
(IR)):
leptin,
Interleukin-1
receptor
antagonist
protein
(IL-1Ra),
polymeric
immunoglobulin
(PIGR),
interleukin-18
(IL-18Ra),
C-C
motif
chemokine
3
(MIP-1a),
angiopoietin-1
(ANGPT1)
upregulated
whilst
advanced
glycosylation
end
product-specific
receptor,
soluble
(sRAGE),
bone
morphogenetic
6
(BMP6);
growth/differentiation
factor
2
(GDF2),
superoxide
dismutase
[Mn]
mitochondrial
(MnSOD),
SLAM
family
member
5
(SLAF5)
downregulated
versus
controls.
(overweight/obese,
BMI
≥
26
kg/m2)
subset
six
common
whole
set:
ANGPT1
IL-1Ra
upregulated;
sRAGE,
BMP6,
GDF2,
Mn-SOD
downregulated.
addition,
lymphotactin
(XCL1)
was
placenta
growth
(PIGF),
alpha-L-iduronidase
(IDUA),
(sTie-2)
macrophage
metalloelastase
(MMP12)
A
analysis
plus
(IR)-matched
revealed
only
upregulation
tissue
(TF)
renin
PCOS,
potentially
serving
as
combination
obesity-related
(ANGPT1/IL/1Ra/XCL1)
cardioprotective
(sRAGE/BMP6/Mn-SOD/GDF2)
may
contribute
CVD.
TF
observed
BMI-
IR-matched
limited
sample
subgroup
indicates
their
