Analysis of transporter activity in an Alzheimer’s disease blood-brain barrier cell model DOI Creative Commons
J. Chaves

Published: Jan. 1, 2024

This thesis investigates blood-brain barrier (BBB) transporter changes in Alzheimer’s disease (AD) using stem cell models. It reviews BBB function AD and successfully differentiates cells into components. Findings suggest dysregulation of certain transporters AD, potentially contributing to onset. study also explores inflammation's impact on expression suggests non-invasive modulation as a therapeutic avenue. Additionally, it inflammatory responses SARS-CoV-2 spike protein exposure cell-derived cells, indicating potential implications for COVID-19 manifestation.

Language: Английский

Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease DOI Creative Commons
Alina Simona Șovrea, Adina Bianca Boşca, Eleonora Dronca

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 84 - 84

Published: Jan. 1, 2025

Despite the massive efforts of modern medicine to stop evolution Alzheimer’s disease (AD), it affects an increasing number people, changing individual lives and imposing itself as a burden on families health systems. Considering that vast majority conventional drug therapies did not lead expected results, this review will discuss newly developing alternative in effort or slow AD. Focused Ultrasound (FUS) its derived Transcranial Pulse Stimulation (TPS) are non-invasive therapeutic approaches. Singly applied technique change permeability blood–brain–barrier (BBB), FUS TPS have demonstrated benefits use treating AD animal human studies. Adipose-derived stem Cells (ADSCs), gene therapy, many other methods (diet, sleep pattern, physical exercise, nanoparticle delivery) also new potential treatments since multimodal approaches represent trend disorder research therapies.

Language: Английский

Citations

0
Focused Ultrasound Sonications of Tumor Model in Head Phantom under MRI Monitoring: Effect of Skull Obstruction on Focal Heating DOI Creative Commons
Anastasia Antoniou,

Antreas Chrysanthou,

Leonidas Georgiou

et al.

Journal of Medical Physics, Journal Year: 2025, Volume and Issue: 50(1), P. 38 - 45

Published: Jan. 1, 2025

This study presents the outcomes of a series magnetic resonance imaging (MRI)-guided focused ultrasound (MRgFUS) sonications performed on an anatomically accurate head phantom with embedded tumor simulator to evaluate effectiveness partial and complete ablation obstruction from thin polymer skull mimics. The was subjected single grid using single-element concave transducer integrated MRI-compatible (FUS) robotic system. All experiments were carried out in high-field MRI scanner utilizing proton frequency thermometry T2-weighted (T2-W) turbo spin echo (TSE) induced thermal effects. FUS transmission through 1-mm thick three-dimensional-printed mimics compared unobstructed sonication circular aperture model. T2-W TSE demonstrated sharp contrast between hyperintense lesions. Complete coverage achieved robotic-assisted without mimic, as well resin mimic intervening beam. With lowest attenuation among tested polymers, resulted approximately 20% reduction focal temperature change sonication, yet still facilitated beam focusing, raising ablative levels. provides preliminary evidence for potential application biocompatible implant temporarily replace portion facilitating MRgFUS inoperable tumors transducer. tumor-embedded proven effective testing oncological protocols equipment.

Language: Английский

Citations

0
Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming DOI Creative Commons
Boqiang Fan, Wayne K. Goodman, Sameer A. Sheth

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Low-intensity focused ultrasound (LIFU) neuromodulation requires precise targeting and high resolution enabled by phased array transducers beamforming. However, focusing optimization usually relies on phantom measurements or simulations with inaccurate acoustic properties to degrade resolution. Therefore, this work analyzes the sensitivity of resolution, measured off-target activation area (OTAA), brain tissue sound speed. A Robust Optimal Resolution (ROR) beamforming method is proposed minimize worst-case OTAA restricted speed inaccuracy propagation information estimated deviated The estimation model utilizes equivalent source (ESM) map field between different parameter sets. Simulation in a human head validates effectiveness model, shows that ROR can significantly reduce compared benchmark methods [Formula: see text] average up text], improving robustness stimulation addressing issue. This allows reliable high-resolution potential clinical applications reduced invasive acquisition for optimization.

Language: Английский

Citations

0
Skull-Mimicking Phantoms with Tunable Properties for Transcranial Ultrasound Imaging DOI Creative Commons
Loïc Saint‐Martin, Kamran Avanaki

IEEE Access, Journal Year: 2025, Volume and Issue: 13, P. 79503 - 79515

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advancements in ultrasound-mediated drug delivery for central nervous system disorders DOI

Chi-Fen Chuang,

Thi-Nhan Phan, Ching‐Hsiang Fan

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Dec. 3, 2024

Central nervous system (CNS) disorders present major therapeutic challenges due to the presence of blood - brain barrier (BBB) and disease heterogeneity. The BBB impedes most agents, which restricts conventional treatments. Focused ultrasound (FUS) -assisted delivery offers a novel solution by temporarily disrupting thereby enhancing drug CNS.

Language: Английский

Citations

1
MRI compatibility testing of commercial high intensity focused ultrasound transducers DOI
Nikolas Evripidou, Anastasia Antoniou, Leonidas Georgiou

et al.

Physica Medica, Journal Year: 2023, Volume and Issue: 117, P. 103194 - 103194

Published: Dec. 3, 2023

Language: Английский

Citations

2
Effect of Magnetic Resonance Imaging on the Motion Accuracy of Magnetic Resonance Imaging-compatible Focused Ultrasound Robotic System DOI Creative Commons
Anastasia Antoniou, Nikolas Evripidou,

Antreas Chrysanthou

et al.

Journal of Medical Physics, Journal Year: 2024, Volume and Issue: 49(2), P. 203 - 212

Published: April 1, 2024

Purpose: The current study provides insights into the challenges of safely operating a magnetic resonance imaging (MRI)-guided focused ultrasound (MRgFUS) robotic system in high-field MRI scanner terms motion accuracy. Materials and Methods: Grid sonications were carried out phantoms excised porcine tissue 3T using an existing MRgFUS system. Fast low-angle shot-based thermometry was employed for intraprocedural monitoring thermal distribution. Results: Strong shifting heated spots from intended points observed owing to electromagnetic interference (EMI)-induced malfunctions system’s operation. Increasing slice thickness sequence at least 8 mm proven efficient method preserving Conclusions: These findings raise awareness about EMI effects on accuracy devices how they can be mitigated by employing suitable parameters.

Language: Английский

Citations

0
Analysis of transporter activity in an Alzheimer’s disease blood-brain barrier cell model DOI Creative Commons
J. Chaves

Published: Jan. 1, 2024

This thesis investigates blood-brain barrier (BBB) transporter changes in Alzheimer’s disease (AD) using stem cell models. It reviews BBB function AD and successfully differentiates cells into components. Findings suggest dysregulation of certain transporters AD, potentially contributing to onset. study also explores inflammation's impact on expression suggests non-invasive modulation as a therapeutic avenue. Additionally, it inflammatory responses SARS-CoV-2 spike protein exposure cell-derived cells, indicating potential implications for COVID-19 manifestation.

Language: Английский

Citations

0