Nutritional profile and pharmacological aspect of Houttuynia cordata Thunb. and their therapeutic applications

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2023, Volume and Issue: 9, P. 100311 - 100311

Published: Sept. 29, 2023

Houttuynia cordata Thunb, a perennial plant indigenous to East Asia and the northeastern region of India, belongs Saururaceae family. Thriving in shaded environments, this is commonly harvested from moist habitats local markets for research purposes, while also serving as valuable resource various sectors, including food, medicine, commerce. This study aims comprehensively explore plant's morphology, distribution, traditional uses, nutritional composition, pharmacological characteristics, prominent bioactive compounds, therapeutic applications, potential future prospects. The involves an extensive review existing literature findings concerning cordata. Information regarding its botanical geographical historical utilization collected diverse sources. reveal that possesses wide range antibacterial, antifungal, antimicrobial, antiviral, anticancer, antimutagenic, anti-obesity, anti-corona, antioxidative, anti-inflammatory activities. Notably, significant compounds extracted plant, such quercetin, quercitrin, isoquercitrin, exhibit promising applications. underscores importance natural with rich history use burgeoning recognition Its properties, ranging combating infections addressing chronic diseases like cancer, highlight significance modern medicine. presence major particularly flavonoids, further accentuates pharmaceutical industries. Looking ahead, should prioritize vitro vivo clinical experiments advance our understanding mechanisms action enhance contribution human healthcare.

Language: Английский

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Phyto-chemistry and Therapeutic Potential of Natural Flavonoid Naringin: A Consolidated Review

Chinese Journal of Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

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Metal-based nanoplatforms for enhancing the biomedical applications of berberine: current progress and future directions

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: March 20, 2025

The isoquinoline alkaloid berberine, a bioactive compound derived from various plants, has demonstrated extensive therapeutic potential. However, its clinical application is hindered by poor water solubility, low bioavailability, rapid metabolism, and insufficient targeting. Metal-based nanoplatforms offer promising solutions, enhancing drug stability, controlled release, targeted delivery. This review comprehensively explores the synthesis, physicochemical properties, biomedical applications of metal-based nanocarriers, including gold, silver, iron oxide, zinc selenium, magnetic nanoparticles, for berberine delivery to improve berberine's efficacy. Recent advancements in nanocarrier systems have significantly improved cellular uptake, extending circulation time, enabling site-specific encounter several limitations potential toxicity, limited large-scale productions, regulatory constraints. Addressing these necessitates studies on biocompatibility, long-term safety, translation. By summarizing latest innovations perspectives, this aims guide future research toward optimizing berberine-based nanomedicine

Language: Английский

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Protective Effects of Bioactive Compound-Derived Nanoparticle Against Diabetic Retinopathy Through the Modulation of the NF-κB Signaling Pathway

ACS Omega, Journal Year: 2024, Volume and Issue: 9(24), P. 26267 - 26274

Published: June 5, 2024

Diabetic retinopathy is a prevalent and severe microvascular complication of diabetes, often causing visual impairment blindness in adults. This condition significantly impacts the quality life for many diabetes patients worldwide. Berberine (BBR), bioactive compound known its effects on blood glucose levels, has shown promise managing diabetic complications. However, exact mechanism how BBR influences development remains unclear. In this study, we focused synthesizing formulation derived from assessing protective against retinopathy. The was created using green synthesis method thoroughly characterized. vitro studies demonstrated antioxidant activity 2,2-diphenyl-1-picryl-hydrazyl-hydrate. We also examined NF-κB signaling pathway at molecular level real-time polymerase chain reaction. To mimic controlled setting, rat model established through streptozotocin injection. rats were divided into normal, diabetic, treatment groups. group received formulated via intragastric administration several weeks, while other groups normal saline. Evaluation histopathological characteristics microstructural changes retina hematoxylin eosin staining revealed that compound-derived nanoparticle exhibited favorable biological, chemical, physical properties. Treatment with effectively reduced oxidative stress induced by inhibited model. Under high conditions, heightened, leading to mitochondria-dependent cell apoptosis Müller cells activation pathway. counteracted these decreasing IκB phosphorylation, preventing nuclear translocation, deactivating Furthermore, mitigated retinal micro- ultrastructural associated These results indicate protects suppressing stress, reducing apoptosis, suggests could be promising therapeutic option

Language: Английский

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Antioxidant and Cytotoxic Properties of <em>Berberis vulgaris</em> (L.) Stem Bark Dry Extract

Published: April 2, 2024

Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigates B. stem bark (Berberidis cortex) by extraction with 50% ethanol. main secondary metabolites were quantified, resulting a polyphenols content of 17.6780 ± 3.9320 mg Eq Tannic acid / 100 g extract, phenolic acids amount 3.3886 0.3481 Chlorogenic extract 78.95 µg/g berberine. dried hydro-ethanolic (BVE) was thoroughly analyzed using Ultra-High Performance Liquid Chromatography coupled High-Resolution Mass Spectrometry (UHPLC–HRMS/MS) HPLC 40 bioactive constituents identified. Then, the antioxidant potential BVE evaluated three methods; our results could explain protective effects Berberidis cortex EC50FRAP = 0.1398 mg/mL, IC50ABTS 0.0442 IC50DPPH 0.2610 mg/mL compared to ascorbic (IC50 0.0165 mg/mL). Next, acute toxicity teratogenicity Berberine - sulfate hydrate (BS) investigated on Daphnia sp reported significant BS after 24 h; revealed considerable 48 hours induced embryonic developmental delays. Finally, anticancer different tumor cell lines treatments. MTS assay evidenced dose- time-dependent antiproliferative activity, higher than BVE. strongest diminution viability recorded breast (MDA-MB-231), colon (LoVo) cancer, OSCC (PE/CA-PJ49) h exposure &amp;lt; µg/mL). However, no cytotoxicity normal epithelial cells (HUVEC) hepatocellular carcinoma (HT-29) lines. Extensive data analysis supports results, showing correlation between BVE&#039;s concentration, compounds content, time, rate various cancer

Language: Английский

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Berberine-styrene-co-maleic acid nanomicelles: unlocking opportunities for the treatment and prevention of bacterial infections

RSC Advances, Journal Year: 2024, Volume and Issue: 14(46), P. 34066 - 34080

Published: Jan. 1, 2024

The produced SMA-BER and SMA-NR16 nanomicelles proved to be a valid safe tool contrast bacterial infections biofilm formation.

Language: Английский

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Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2053 - 2053

Published: April 29, 2024

Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. stem bark (Berberidis cortex) by extraction with 50% ethanol. main secondary metabolites were quantified, resulting a polyphenols content of 17.6780 ± 3.9320 mg Eq tannic acid/100 g extract, phenolic acids amount 3.3886 0.3481 chlorogenic extract 78.95 µg/g berberine. dried hydro-ethanolic (BVE) was thoroughly analyzed using Ultra-High-Performance Liquid Chromatography coupled High-Resolution Mass Spectrometry (UHPLC–HRMS/MS) HPLC, 40 bioactive constituents identified. Then, the antioxidant potential BVE evaluated three methods. Our results could explain protective effects Berberidis cortex EC50FRAP = 0.1398 mg/mL, IC50ABTS 0.0442 IC50DPPH 0.2610 mg/mL compared to ascorbic acid (IC50 0.0165 mg/mL). Next, acute toxicity teratogenicity berberine—berberine sulfate hydrate (BS)—investigated on Daphnia sp. revealed significant BS after 24 h, while considerable 48 h induced embryonic developmental delays. Finally, anticancer different tumor cell lines treatments. MTS assay evidenced dose- time-dependent antiproliferative activity, which higher for than BVE. strongest diminution viability recorded breast (MDA-MB-231), colon (LoVo) cancer, OSCC (PE/CA-PJ49) exposure < 100 µg/mL). However, no cytotoxicity reported normal epithelial cells (HUVEC) hepatocellular carcinoma (HT-29) lines. Extensive data analysis supports our results, showing correlation between concentration, compounds content, time, rate various cancer

Language: Английский

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Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Doxorubicin (DOX) is a chemotherapy drug widely used in clinical settings, acting as first‐line treatment for various malignant tumors. However, its use greatly limited by the cardiotoxicity it induces, including doxorubicin‐induced cardiomyopathy (DIC). The mechanisms behind DIC are not fully understood, but potential biological thought to include oxidative stress, inflammation, energy metabolism disorders, mitochondrial damage, autophagy, apoptosis, and ferroptosis. Recent studies have shown that cardiac injury induced DOX closely related Due their high efficacy, availability, low side effects, natural medicine treatments hold strong potential. Currently, medicines been mitigate DOX‐induced ferroptosis ease through functions such antioxidation, iron ion homeostasis correction, lipid regulation, function improvement. Therefore, this review summarizes of regulation plant products, with expectation providing reference future research development inhibitors targeting DIC. This explores (DIC) how products can alleviate inhibiting reducing correcting homeostasis, regulating metabolism, improving function.

Language: Английский

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Study the Physiological and Biochemical Effects of Berberine Extract on Nonalcoholic Fatty Liver Disease (NAFLD) in Male Rabbits

South Asian Research Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 6(03), P. 44 - 47

Published: May 4, 2024

Nonalcoholic fatty liver disease (NAFLD) is a prevalent global health issue, characterized by hepatic steatosis and associated with metabolic comorbidities such as obesity, diabetes, dyslipidemia. Berberine (BBR), an isoquinoline alkaloid, has emerged potential therapeutic agent for NAFLD. In this research, we evaluated the effects of BBR on NAFLD management its complications. Our analysis included three groups involving 10 rabbits induced administration cholesterol rich diet, administrated high diet fats cholesterol, normal fed control group. demonstrated significant improvements in function biochemical markers (ALT, AST, GGT), lipid indices (TC, TG, LDL-C, HDL-C), physiological parameters insulin sensitivity (HOMA-IR) body mass index (BMI). Importantly, exhibited favorable safety profile, minimal gastrointestinal adverse events reported. These findings highlight adjunct therapy However, further well-designed clinical trials human subjects are warranted to validate efficacy safety.

Language: Английский

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Chitosan-based nanoformulations for alopecia treatment

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 327 - 345

Published: Nov. 8, 2024

Language: Английский

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