Association between four anthropometric indices with age-related Macular Degeneration from NHANES 2005–2008

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 11, 2025

Age-related macular degeneration (AMD) decrease vision and presents considerable challenges for both public health clinical management strategies. Obesity is usually implicated with increased AMD, body mass index (BMI) does not reflect fat distribution. An array of studies has indicated a robust relationship between distribution obesity. This research to evaluate the anthropometric measurements AMD in United States citizens cohort patients. Our study included 3,127 participants, all whom were selected from National Health Nutrition Examination Survey (NHANES) conducted 2005 2008. Various indices, including weight (WT), waist circumference (WC), Body Mass Index (BMI), waist-to-height ratio (WtHR), circularity (CI), weight-adjusted (WWI), roundness (BRI), size (ABSI), visceral adiposity (VAI), have been studied extensively within nutrition assess Odds ratios (OR) each index, relation its different stages, computed, adjusting confounding variables. Smoothed curve fitting, coupled weighted multivariable logistic regression analysis, was used examine impact these measures on prevalence AMD. Subgroup analyses according gender, age, BMI, drinking, smoking, CVD, diabetes, hypertension, cataract operation, glaucoma. After variables, significant positive correlations observed WtHR (OR = 1.237 (1.065-1.438)), BRI 1.221 (1.058-1.410)), CI 1.189 (1.039-1.362)), WWI 1.250 (1.095-1.425)) particularly early However, no effects indicators late exhibited linear Two-segment modeling revealed nonlinear associations WtHR, BRI, The association more pronounced excessive alcohol consumption CI, (P interaction 0.0033, 0.0021, 0.0194, 0.0022, respectively). Additionally, stronger females 0.0146 0.0117, Furthermore, associated non-smokers 0.0402). confirmed risk four measures, WWI, especially findings suggest that indices should be broadly utilized improve prevention treatment we found measurement individuals high consumption.

Language: Английский

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A 2-Years Comparative Analysis of Tirzepatide, Semaglutide, Qsymia, Contrave, and Phentermine on Ocular Health in Individuals with Obesity: A Propensity-Score Matched Cohort Study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

This landmark propensity-score matched study examined ocular outcomes of modern anti-obesity medications in nearly 5 million non-diabetic individuals with obesity. Through analysis TriNetX US network data, we discovered that Tirzepatide significantly reduced cataract risk versus other treatments, showing a striking 59% lower compared to Semaglutide (HR: 0.41, 95% CI: 0.19–0.85). users experienced markedly fewer visual disturbances than those on Contrave 0.58, 0.41–0.82) or Phentermine 0.62, 0.46–0.82). Both GLP-1 receptor agonists demonstrated protection against age-related cataracts, exceptional benefits 0.17, 0.07–0.42). While these protective effects remained robust across patient subgroups, Tirzepatide's diminished impaired kidney function. Multiple sensitivity analyses and negative controls validated compelling findings.

Language: Английский

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Retinal physiology in metabolic syndrome

Advances in genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Obesity and its management in primary care setting

Journal of Diabetes and its Complications, Journal Year: 2025, Volume and Issue: 39(7), P. 109045 - 109045

Published: April 19, 2025

Language: Английский

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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

Objective This study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults. Methods The utilized data from two consecutive cycles of National Health Nutrition Examination Survey (NHANES) 2005 2008. A multivariate weighted logistic regression model was employed explore OBS VRFB general population subgroups, while interaction effects were tested with a likelihood test. Restricted cubic spline assess nonlinear association VRFB. Sensitivity analyses performed test robustness results. Results total 6,682 participants aged 20 years older included NHANES database. negative observed fully adjusted model, an odds ratio (OR) 0.968 [95% confidence interval (CI): 0.949–0.987]. Compared lowest quartile OBS, second (OR: 0.669, 95%CI: 0.486–0.922), third 0.589, 0.403–0.859), highest 0.554, 0.359–0.855) quartiles associated reduced risk An L-shaped displayed ( P for = 0.016). Notably, when analysis stratified by employment status, significant < 0.05). protective effect more pronounced among unemployed. results found be robust sensitivity analyses. Conclusion U.S. adults older. novel finding suggests that maintaining favorable through modifiable dietary lifestyle (such as increased physical activity, smoking cessation, alcohol consumption) may help protect vision. We also stronger provides new insights into prevention vision loss, highlighting importance not only factors but considering different such Further longitudinal studies are required further validate these observations elucidate underlying mechanisms, particularly elucidating causal relationships variables, controlling confounding factors, examining development visual function.

Language: Английский

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Risk factors for diabetic retinopathy in young and middle-aged patients: a retrospective study

BMC Ophthalmology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 22, 2024

To investigate the related risk factors of retinopathy in young and middle-aged diabetic patients order to improve prognosis patients. Using clinical practice data from a cohort study at our two research centers, we developed bivariate logistic regression model frightening potentially for with diabetes, including diabetes type, physical activity level, treatment-related characteristics laboratory tests. A total 453 were investigated, 197 (43.5%) retinopathy. The was closely place residence (OR: 0.275, 95% CI: 0.093–0.814), education level 0.522, 0.363–0.749), medical payment method 2.152, 1.308–3.539), BMI 1.187, 1.091–1.291), disease course 1.072, 1.028–1.118), hyperlipidemia 2.547, 1.260–5.150), 0.312, 0.220–0.443), dietary compliance (OR 0.871, 0.806–0.940). area under receiver operator characteristic curve 0.915. Goodness fit (Hosmer–Lemeshow) 0.658. increased as result certain patient complications, especially lower level.

Language: Английский

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The relationship between weight-adjusted-waist index, body mass index and diabetic retinopathy among American adults: a population-based analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 11, 2024

Diabetic retinopathy (DR) is a common complication of diabetes, with its prevalence increasing globally. While previous research has linked obesity indices such as body mass index (BMI) to DR, the association weight-adjusted-waist (WWI) remains unclear. Additionally, relationship between WWI and DR not been fully elucidated. This cross-sectional study analyzed data from National Health Nutrition Examination Survey (2005–2008) investigate these associations in Americans aged 40 above. The included 5436 participants (2705 men 2731 women). Weighted logistic regression analysis revealed significant increase higher BMI values. Smooth curve demonstrated linear correlation DR. findings suggest that both are independently associated risk among older US adults, highlighting importance considering central measures assessing diabetic complications.

Language: Английский

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