Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(1), P. 75 - 90

Published: Jan. 23, 2024

BACKGROUND Prevalence of hepatocellular carcinoma (HCC) is increasing, especially in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). AIM To investigate rifaximin (RIF) effects on epigenetic/autophagy markers animals. METHODS Adult Sprague-Dawley rats were randomly assigned (n = 8, each) and treated from 5-16 wk: Control [standard diet, water plus gavage vehicle (Veh)], HCC [high-fat choline deficient diet (HFCD), diethylnitrosamine (DEN) drinking Veh gavage], RIF [HFCD, DEN (50 mg/kg/d) gavage]. Gene expression circulating miRNAs obtained. RESULTS All animals developed metabolic-dysfunction associated steatohepatitis fibrosis, cirrhosis, but three RIF-group did not develop HCC. Comparing who those not, miR-122, miR-34a, tubulin alpha-1c (Tuba-1c) , metalloproteinases- 2 (Mmp2) 9 (Mmp9) significantly higher the HCC-group. The opposite occurred Becn1 coactivator arginine methyltransferase-1 (Carm1 ), enhancer zeste homolog-2 (Ezh2 ) autophagy-related factor LC3A/B (Map1 Lc3b) p62/ sequestosome-1 (p62/ SQSTM1)- protein. controls, Map1 Lc3b Ezh2 lower RIF-groups (P < 0.05). Carm1 was compared to Hepatic Mmp9 relation control; observed for p62/Sqstm1 Expression p62/SQSTM1 protein control 0.024). There no difference among groups Tuba-1c Aldolase-B, alpha-fetoprotein, Mmp2 > miR-122 HCC, miR-34a controls miR-26b RIF, inverse miR-224 regarding miR-33a, miR-143, miR-155, miR-375 miR-21 CONCLUSION might have a possible beneficial effect preventing/delaying carcinogenesis through epigenetic modulation rat model MASLD-HCC.

Language: Английский

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Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 9, 2024

Abstract Background Abdominal aortic calcification (AAC) is a crucial indicator of cardiovascular health. This study aims investigates the associations between dietary fatty acid intake and AAC. Methods In this study, cross-sectional assessment was performed on group 2,897 individuals aged 40 above, utilizing data from NHANES. The focus examining consumption various acids, including Saturated (SFA), Monounsaturated (MUFA), Polyunsaturated (PUFA), as well Omega-3 Omega-6. evaluation AAC done by applying Kauppila score to results obtained dual-energy X-ray absorptiometry scans. For statistical analysis, weighted multivariate linear logistic regression were employed, with adjustments for variables like gender, age, ethnicity, overall health condition. Results Participants higher SFA PUFA showed positive association score, while levels Omega-6 acids connected negative correlation. Subgroup analyses indicated consistent across different sexes age groups. found that an increase in correlated whereas decrease. Conclusion underscores importance composition prevalence its potential implications guidelines disease prevention strategies.

Language: Английский

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Testosterone does not mediate the correlation between dietary inflammation and serum klotho levels among males: insights from NHANES database

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 2, 2024

Introduction Serum Klotho (S-Klotho) is a transmembrane protein holds pivotal roles in anti-aging. The Dietary Inflammation Index (DII), meticulously dietary tool, quantifies the inflammatory potential of an individual's diet. existing research strongly suggests that low DII diet plays significant role delaying aging and reducing aging-related symptoms males. Testosterone could potentially act as mediating intermediary between S-Klotho. However, this aspect remains unexplored. This study aims to investigate causal link testosterone S-Klotho Methods We utilized data from National Health Nutrition Examination Survey (NHANES) which focused on male participants 2013-2016. Mediation analyses were used effects (TT), free (FT), androgen index (FAI) DII-S-Klotho relationship, using three modes adjusting for covariates. Results analysis unveiled inverse correlation levels (model 1: c = -14.78, p 0.046). interaction was modulated by TT model 1 (ab -1.36; 95% CI: -5.59, -0.55; 0.008), but lost significance after adjustments 2: ab -0.39; -4.15, 1.66; 0.378; 3: -0.59; -4.08, 2.15; 0.442). For FT, impact not statistically 0.43; -0.51, 5.44; 0.188; 0.72; -0.26, 5.91; 0.136; 0.84; -0.02, 8.06; 0.056). Conversely, FAI consistently influenced relationship 2.39; 0.69, 9.42; 0.002), maintaining 3.2; 0.98, 11.72; 0.004; 3.15; 0.89, 14.51; 0.026). Discussion observed no influence or FT covariate control. Remarkably, continued significantly mediate connection even following adjustment, although its males warrants careful consideration.

Language: Английский

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Association of hepatic steatosis and liver fibrosis with chronic obstructive pulmonary disease among adults

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 11, 2024

Abstract With high prevalence and substantial mortality, metabolic dysfunction-associated steatotic liver disease chronic obstructive pulmonary (COPD) are significant public health concerns. Utilizing a large, population-based dataset from the National Health Nutrition Examination Survey, our study probes relationship between COPD hepatic steatosis fibrosis, as measured by Vibration-Controlled Transient Elastography. We analyzed data 693 individuals with 7229 without. Through weighted multivariate logistic regression analysis, restricted cubic spline curve, threshold effect we investigated correlation severity of fibrosis presence COPD. Our findings revealed positive controlled attenuation parameter (CAP) [OR = 1.03 (95% CI 1.01, 1.05)], even after adjustment. Furthermore, observed U-shaped association CAP COPD, where inflection point, value 264.85 dB/m, corresponded to lowest prevalence. emphasizes complex link These urge healthcare professionals factor into management prompt further exploration underlying mechanisms. This could pave way for development improved prevention treatment strategies.

Language: Английский

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Association between bedtime and female infertility: a secondary analysis from a cross-sectional study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

Objective To evaluate the association between bedtime and infertility to identify optimal for women of reproductive age. Methods We conducted a cross-sectional study using data from 3,903 female participants in National Health Nutrition Examination Survey (NHANES) 2015 2020. The effect on was assessed binary logistic regression different models, including crude model adjusted models. non-linear correlation infertility, generalized additive models (GAM) were utilized. Subgroup analyses by age, body mass index (BMI), waist circumference, physical activity total time, marital status, smoking drinking status sleep duration. Results After adjusting potential confounders (age, race, duration, education, BMI, time), relationship observed with inflection point at 22:45. left side point, no significant detected. However, right it, positively related (OR: 1.22; 95% CI: 1.06 1.39; P = 0.0049). showed that late sleepers higher BMI more prone than those lower (BMI: 25–30 kg/m 2 : OR: 1.26; 1.51; 0.0136; ≥ 30 kg/m²: 1.21, 1.09 1.34; 0.0014). Conclusion Bedtime non-linearly associated which may provide guidance behavior childbearing

Language: Английский

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