Ten-year atherosclerotic cardiovascular disease risk score in post-menopausal women with low bone mineral density
Aging Clinical and Experimental Research,
Journal Year:
2025,
Volume and Issue:
37(1)
Published: Feb. 27, 2025
Abstract
Background
Reports
on
the
association
between
cardiovascular
disease
(CVD)
risk
and
bone
mineral
density
(BMD)
remain
inconsistent
hence
more
population-based
studies
this
subject
are
needed.
Aims
This
cross-sectional
study
aimed
to
evaluate
at
lumbar
spine
(L1-L4)
femoral
neck
(right
left)
with
10-year
atherosclerotic
(ASCVD)
scores
in
Saudi
postmenopausal
women.
Methods
A
cohort
of
1,450
women
factors
for
loss
were
analyzed
using
data
from
Chair
Biomarkers
Chronic
Diseases
(CBCD)
Osteoporosis
database.
BMD
was
assessed
dual-energy
X-ray
absorptiometry
(DXA).
Anthropometric
biochemical
parameters,
including
fasting
glucose
lipid
profiles,
measured.
ASCVD
calculated
Risk
Estimator
Plus
tool.
tertiles
their
risk.
Results
Women
osteoporosis
had
significantly
lower
BMI,
waist
hip
circumferences,
metabolic
dysfunction
markers
compared
those
normal
BMD.
Significant
negative
correlations
observed
sites
osteopenia
osteoporosis.
Multivariate
logistic
regression
indicated
that
lowest
higher
odds
intermediate
high
scores,
adjusted
ratios
1.90
spine,
2.19
right
neck,
2.04
left
neck.
Conclusions
The
identified
significant
associations
elevated
women,
particularly
among
These
findings
demonstrate
importance
assessing
low
enable
early
prevention
management
strategies.
Language: Английский
Association Between Alcohol Consumption, Other Healthy Habits and Sociodemographic Variables and the Values of Different Insulin Resistance Risk Scales in 139,634 Spanish Workers
Healthcare,
Journal Year:
2025,
Volume and Issue:
13(8), P. 921 - 921
Published: April 17, 2025
Background:
Alcohol
consumption
is
a
major
public
health
concern,
influencing
metabolic
and
insulin
resistance
(IR).
While
moderate
alcohol
intake
has
been
associated
with
potential
benefits,
excessive
linked
to
IR
related
disorders.
This
study
examines
the
association
between
sociodemographic
variables,
habits,
risk
using
validated
indices.
Methods:
A
dual-phase
was
conducted,
including
cross-sectional
analysis
of
139,634
Spanish
workers
retrospective
longitudinal
follow-up
40,431
participants
(2009–2019).
Data
on
factors
(age,
sex
socioeconomic
status)
habits
(smoking,
consumption,
diet
physical
activity)
were
collected
through
standardized
occupational
assessments.
assessed
Triglyceride-Glucose
Index
(TyG),
Metabolic
Score
for
Insulin
Resistance
(METS-IR),
Single-Point
Sensitivity
Estimator
(SPISE-IR).
Binary
logistic
regression
used
statistical
analysis.
Results:
Age,
male
sex,
lower
status,
smoking,
inactivity
low
adherence
Mediterranean
significantly
higher
across
all
indices
(p
<
0.001).
exhibited
dose-dependent
relationship
IR,
increasing
IR.
Longitudinal
data
revealed
worsening
profile
over
time,
particularly
among
older,
low-income
physically
inactive
individuals.
Conclusions:
Sociodemographic
lifestyle
strongly
influence
Preventive
strategies
focused
reducing
smoking
cessation
promoting
activity
dietary
improvements
are
essential
mitigate
especially
in
vulnerable
populations.
Further
studies
needed
establish
causal
relationships
refine
intervention
strategies.
Language: Английский