Toxicity evolution of triclosan during environmental transformation and human metabolism: Misgivings in the post-pandemic era DOI Creative Commons
Na Luo, Jia Chen, Xiaoyi Chen

et al.

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108927 - 108927

Published: Aug. 1, 2024

In the context of pandemic viruses and pathogenic bacteria, triclosan (TCS), as a typical antibacterial agent, is widely used around world. However, health risks from TCS increase with exposure, it widespread in environmental human samples. Notably, transformation metabolism could induce potentially undesirable to humans, rather than simple decontamination or detoxification. This review summarizes exposure covering 2004 2023. Particularly, impacts metabolic are emphasized. Environmental transformations aimed at recognized form carcinogenic products such dioxins, ultraviolet light excessive active chlorine can promote formation these dioxin congeners, threatening health. Although be rapidly metabolized for detoxification, processes lipophilic ether analogs via cytochrome P450 catalysis, causing possible adverse cross-talk reactions disorders. Accordingly, may more harmful metabolism. particular, stimulate transmission antibiotic resistance even trace levels, public Considering accruing epidemiological toxicological studies indicating multiple outcomes TCS, we call on toxicologists pay attention toxicity evolution during

Language: Английский

Toxicity evolution of triclosan during environmental transformation and human metabolism: Misgivings in the post-pandemic era DOI Creative Commons
Na Luo, Jia Chen, Xiaoyi Chen

et al.

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108927 - 108927

Published: Aug. 1, 2024

In the context of pandemic viruses and pathogenic bacteria, triclosan (TCS), as a typical antibacterial agent, is widely used around world. However, health risks from TCS increase with exposure, it widespread in environmental human samples. Notably, transformation metabolism could induce potentially undesirable to humans, rather than simple decontamination or detoxification. This review summarizes exposure covering 2004 2023. Particularly, impacts metabolic are emphasized. Environmental transformations aimed at recognized form carcinogenic products such dioxins, ultraviolet light excessive active chlorine can promote formation these dioxin congeners, threatening health. Although be rapidly metabolized for detoxification, processes lipophilic ether analogs via cytochrome P450 catalysis, causing possible adverse cross-talk reactions disorders. Accordingly, may more harmful metabolism. particular, stimulate transmission antibiotic resistance even trace levels, public Considering accruing epidemiological toxicological studies indicating multiple outcomes TCS, we call on toxicologists pay attention toxicity evolution during

Language: Английский

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