Medical Sciences, Journal Year: 2025, Volume and Issue: 13(2), P. 69 - 69
Published: June 1, 2025
Background: This study investigates the combined effects of PFAS metals (PFOA and PFOS), heavy (lead, cadmium, mercury), behavioral factors (smoking alcohol consumption), social (income education) on depressive symptoms. Methods: Using cross-sectional data from National Health Nutrition Examination Survey (NHANES 2017–2018), blood samples were analyzed to determine exposure levels PFOA, PFOS, lead, mercury, self-reported evaluated in relation PHQ-9 scores among 181 adults. Results: Education was associated with lower odds symptoms (OR = 0.68, 95% CI: 0.43–1.07). Although result not statistically significant, estimate suggested a potential protective effect that warranted further investigation. Bayesian Kernel Machine Regression demonstrated collectively had strongest evidence for influencing depression (group PIP 0.6508), followed by socioeconomic 0.642). Bivariate exposure–response analyses revealed complex interaction patterns whereby varied substantially depending co-exposure contexts. Conclusions: These findings highlight are shaped interplays between environmental contaminants, behavior, determinants, underscoring importance mixture-based approaches mental health research need integrated interventions addressing both factors.
Language: Английский