Journal of Health and Rehabilitation Research,
Journal Year:
2024,
Volume and Issue:
4(4), P. 1 - 4
Published: Dec. 31, 2024
Background:
Gut
dysbiosis
has
been
increasingly
implicated
in
the
pathogenesis
of
autoimmune
disorders,
yet
there
is
limited
research
on
its
role
General
Population.
Differences
genetic,
environmental,
and
dietary
factors
necessitate
region-specific
studies
to
better
understand
microbiota-autoimmunity
interactions.
Objective:
To
compare
gut
microbiome
composition
between
individuals
with
disorders
healthy
controls
a
population
identify
microbiota
alterations
associated
conditions.
Methods:
A
case-control
study
was
conducted
138
participants,
comprising
69
matched
controls.
Data
were
collected
demographics,
clinical
history,
habits.
Stool
samples
analyzed
using
16S
rRNA
gene
sequencing,
targeting
V3–V4
regions
assess
microbial
diversity
taxonomic
composition.
Alpha
evaluated
Shannon
index,
beta
through
Bray-Curtis
dissimilarity.
Statistical
analyses
included
t-tests,
chi-square
tests,
logistic
regression
SPSS
version
25.
Results:
Cases
exhibited
significantly
lower
index
scores
(2.8
±
0.4
vs.
3.2
0.5,
p
=
0.01)
reduced
Firmicutes-to-Bacteroidetes
ratio
(1.5
2.2,
0.03).
Enrichment
Prevotella
(12.4%)
Collinsella
(8.5%)
observed
cases
(p
<
0.001).
Logistic
identified
as
an
independent
predictor
(OR:
2.3,
95%
CI:
1.2–4.4,
Conclusion:
characterized
by
altered
general
population.
These
findings
underscore
need
for
microbiome-targeted
interventions
managing
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(4), P. 413 - 413
Published: Feb. 8, 2025
Background:
The
bacterial
gut
microbiome
has
been
the
subject
of
many
studies
that
have
provided
valuable
scientific
conclusions.
However,
different
populations
microorganisms
interact
with
each
other
to
maintain
homeostasis
coexist
inside
gut.
virome,
especially,
appears
play
a
key
role
in
this
interactive
microenvironment.
Intestinal
viral
communities,
including
bacteriophages,
appear
influence
health
and
disease,
although
their
not
yet
fully
elucidated.
In
addition,
bacteriophages
or
viruses
infect
bacteria
regulate
growth,
thus
shaping
composition
affecting
immune
system.
Infant
Gut
Virome:
during
first
years
life
significant
maturation
infant’s
contrast,
early
dysbiosis
associated
chronic,
metabolic
autoimmune,
disorders
later
life.
Purpose:
Although
shown
be
potential
triggers
autoimmune
diseases,
there
is
gap
literature
regarding
infant
virome
autoimmunity
development.
Despite
lack
evidence,
review
attempts
summarize
clarify
what
known
so
far
about
timely
important
topic
hope
its
findings
will
contribute
future
research.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 19, 2024
Gut
microbiota
regulates
the
immune
system,
development
and
progression
of
autoimmune
diseases
(AIDs)
overall
health.
Recent
studies
have
played
a
crucial
part
in
understanding
specific
role
different
gut
bacterial
strains
their
metabolites
AIDs.
Microbial
signatures
AIDs
are
revealed
by
advanced
sequencing
metabolomics
studies.
Microbes
such
as
Faecalibacterium
prausnitzii,
Akkermansia
muciniphila,
Anaerostipes
caccae,
Bacteroides
sp.
,
Roseburia
Blautia
faecis
Clostridium
lavalense
Christensenellaceae
Coprococcus
Firmicutes
Ruminococcaceae
Lachnospiraceae
Megamonas
sp.,
Monoglobus
Streptococcus
pneumoniae
Bifidobacterium
help
maintain
homeostasis;
whereas,
Prevotella
copri,
Ruminococcus
gnavus,
Lactobacillus
salivarius,
Enterococcus
gallinarum,
Elizabeth
menigoseptica,
Collinsella
Escherichia
Fusobacterium
Enterobacter
ludwigii,
Enterobacteriaceae
Proteobacteria
Porphyromonas
gingivalis
nigrescens
Dorea
cause
immuno-pathogenesis.
A
complex
web
interactions
is
influence
on
cells
various
T
cell
subsets
CD4+
cells,
CD8+
natural
killer
γδ
etc.
Certain
AIDs,
including
rheumatoid
arthritis,
diabetes
mellitus,
atopic
asthma,
inflammatory
bowel
disease
non-alcoholic
fatty
liver
exhibit
state
dysbiosis,
characterized
alterations
microbial
diversity
relative
abundance
taxa.
This
review
summarizes
recent
developments
certain
composition
factors
affecting
regulatory
through
also
focuses
potential
application
therapeutic
significance
microbiota-based
interventions
novel
adjunctive
therapies
for
Further
research
to
determine
precise
association
each
strain
required.
Current Clinical Microbiology Reports,
Journal Year:
2024,
Volume and Issue:
11(3), P. 177 - 191
Published: April 19, 2024
Abstract
Purpose
of
review
This
comprehensively
examines
host-vaginal
microbiota
interactions,
the
composition
vaginal
microbiota,
and
its
dynamic
changes
throughout
a
woman's
lifespan.
Furthermore,
intricate
interplay
between
host
beneficial
bacterial
communities,
such
as
Lactobacillus
species,
opportunistic
pathogens,
Gardnerella
spp
.,
associated
with
BV
development,
has
been
explored.
Additionally,
current
advanced
therapeutic
strategies
for
managing
complications
related
to
along
challenges
faced
in
this
field
have
discussed.
Recent
findings
shown
that
microbial
communities
inhabiting
female
vagina,
known
play
critical
role
maintaining
women's
health
supporting
reproductive
activities.
Imbalanced
can
predispose
individuals
range
diseases,
including
vaginosis
(BV),
sexually
transmitted
infections
(STI),
miscarriage,
preterm
birth.
While
exact
mechanisms
by
which
-dominated
microenvironment
improves
remain
elusive,
gaining
insight
into
interactions
well
help
address
unanswered
questions.
Summary
A
deeper
understanding
reciprocal
potential
pave
way
development
novel
diagnostic
interventions
improvement
health.
Universal Journal of Pharmaceutical Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Allulose
and
sugar
alcohols,
like
erythritol
xylitol,
are
low-calorie
sweeteners
gaining
attention
for
their
potential
to
positively
influence
metabolic
health.
This
brief
review
explores
how
these
can
shape
the
gut
microbiota.
Acting
as
prebiotics,
they
foster
growth
of
beneficial
bacteria
stimulate
production
short-chain
fatty
acids.
These
effects
may
contribute
improved
insulin
sensitivity,
reduced
inflammation
a
stronger
barrier.
However,
excessive
alcohol
intake
lead
digestive
discomfort.
Further
research
is
needed
assess
long-term
impact
on
microbiota
health,
well
interactions
with
other
dietary
factors.
By
understanding
intricate
relationship
between
sweeteners,
it
will
be
possible
develop
well-informed
guidelines
optimize
health
well-being.
Peer
Review
History:
Received
5
October
2024;
Reviewed
12
November;
Accepted
22
December;
Available
online
15
January
2025
Academic
Editor:
Prof.
Dr.
Gorkem
Dulger,
Duzce
University,
Turkey,
[email protected]
Average
marks
at
initial
stage:
5.0/10
publication
7.0/10
