The Role of Gut Dysbiosis in Autoimmune Disorders Among General Population DOI
Sadia Ilyas,

Sania Niaz

Journal of Health and Rehabilitation Research, Journal Year: 2024, Volume and Issue: 4(4), P. 1 - 4

Published: Dec. 31, 2024

Background: Gut dysbiosis has been increasingly implicated in the pathogenesis of autoimmune disorders, yet there is limited research on its role General Population. Differences genetic, environmental, and dietary factors necessitate region-specific studies to better understand microbiota-autoimmunity interactions. Objective: To compare gut microbiome composition between individuals with disorders healthy controls a population identify microbiota alterations associated conditions. Methods: A case-control study was conducted 138 participants, comprising 69 matched controls. Data were collected demographics, clinical history, habits. Stool samples analyzed using 16S rRNA gene sequencing, targeting V3–V4 regions assess microbial diversity taxonomic composition. Alpha evaluated Shannon index, beta through Bray-Curtis dissimilarity. Statistical analyses included t-tests, chi-square tests, logistic regression SPSS version 25. Results: Cases exhibited significantly lower index scores (2.8 ± 0.4 vs. 3.2 0.5, p = 0.01) reduced Firmicutes-to-Bacteroidetes ratio (1.5 2.2, 0.03). Enrichment Prevotella (12.4%) Collinsella (8.5%) observed cases (p < 0.001). Logistic identified as an independent predictor (OR: 2.3, 95% CI: 1.2–4.4, Conclusion: characterized by altered general population. These findings underscore need for microbiome-targeted interventions managing

Language: Английский

Digestive health: functional foods for a happy gut DOI

Vaishnavi A. Pathak,

Gitanjali S. Deokar, Sanjay J. Kshirsagar

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 41 - 72

Published: Jan. 1, 2025

Language: Английский

Citations

2

Gut microbiota dysbiosis and associated immune response in systemic lupus erythematosus: impact of disease and treatment DOI Creative Commons
A.A. Ali, Sara A. Zahran, Mervat Eissa

et al.

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 18, 2025

Language: Английский

Citations

1

Therapeutic potential of microbiota modulation in psoriasis: current evidence and future directions DOI
Ali Karimi Bakhshandi, Asal Minasazi, Omid Yeganeh

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 12, 2025

Language: Английский

Citations

1

Gut microbiota mediated T cells regulation and autoimmune diseases DOI Creative Commons
Nabeel Khalid Bhutta, Xiaolin Xu,

Cuiqin Jian

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Gut microbiota regulates the immune system, development and progression of autoimmune diseases (AIDs) overall health. Recent studies have played a crucial part in understanding specific role different gut bacterial strains their metabolites AIDs. Microbial signatures AIDs are revealed by advanced sequencing metabolomics studies. Microbes such as Faecalibacterium prausnitzii, Akkermansia muciniphila, Anaerostipes caccae, Bacteroides sp. , Roseburia Blautia faecis Clostridium lavalense Christensenellaceae Coprococcus Firmicutes Ruminococcaceae Lachnospiraceae Megamonas sp., Monoglobus Streptococcus pneumoniae Bifidobacterium help maintain homeostasis; whereas, Prevotella copri, Ruminococcus gnavus, Lactobacillus salivarius, Enterococcus gallinarum, Elizabeth menigoseptica, Collinsella Escherichia Fusobacterium Enterobacter ludwigii, Enterobacteriaceae Proteobacteria Porphyromonas gingivalis nigrescens Dorea cause immuno-pathogenesis. A complex web interactions is influence on cells various T cell subsets CD4+ cells, CD8+ natural killer γδ etc. Certain AIDs, including rheumatoid arthritis, diabetes mellitus, atopic asthma, inflammatory bowel disease non-alcoholic fatty liver exhibit state dysbiosis, characterized alterations microbial diversity relative abundance taxa. This review summarizes recent developments certain composition factors affecting regulatory through also focuses potential application therapeutic significance microbiota-based interventions novel adjunctive therapies for Further research to determine precise association each strain required.

Language: Английский

Citations

5

Host-vaginal microbiota interaction: shaping the vaginal microenvironment and bacterial vaginosis DOI Creative Commons
Fatemah Sadeghpour Heravi

Current Clinical Microbiology Reports, Journal Year: 2024, Volume and Issue: 11(3), P. 177 - 191

Published: April 19, 2024

Abstract Purpose of review This comprehensively examines host-vaginal microbiota interactions, the composition vaginal microbiota, and its dynamic changes throughout a woman's lifespan. Furthermore, intricate interplay between host beneficial bacterial communities, such as Lactobacillus species, opportunistic pathogens, Gardnerella spp ., associated with BV development, has been explored. Additionally, current advanced therapeutic strategies for managing complications related to along challenges faced in this field have discussed. Recent findings shown that microbial communities inhabiting female vagina, known play critical role maintaining women's health supporting reproductive activities. Imbalanced can predispose individuals range diseases, including vaginosis (BV), sexually transmitted infections (STI), miscarriage, preterm birth. While exact mechanisms by which -dominated microenvironment improves remain elusive, gaining insight into interactions well help address unanswered questions. Summary A deeper understanding reciprocal potential pave way development novel diagnostic interventions improvement health.

Language: Английский

Citations

4

THE ROLE OF ALLULOSE AND SUGAR ALCOHOLS IN GUT MICROBIOTA MODULATION AND METABOLIC HEALTH: A REVIEW DOI Open Access
Mostafa Essam Eissa

Universal Journal of Pharmaceutical Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Allulose and sugar alcohols, like erythritol xylitol, are low-calorie sweeteners gaining attention for their potential to positively influence metabolic health. This brief review explores how these can shape the gut microbiota. Acting as prebiotics, they foster growth of beneficial bacteria stimulate production short-chain fatty acids. These effects may contribute improved insulin sensitivity, reduced inflammation a stronger barrier. However, excessive alcohol intake lead digestive discomfort. Further research is needed assess long-term impact on microbiota health, well interactions with other dietary factors. By understanding intricate relationship between sweeteners, it will be possible develop well-informed guidelines optimize health well-being. Peer Review History: Received 5 October 2024; Reviewed 12 November; Accepted 22 December; Available online 15 January 2025 Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, [email protected] Average marks at initial stage: 5.0/10 publication 7.0/10

Language: Английский

Citations

0

Beyond the microbiome: unraveling gut dysbiosis and its impact on systemic lupus erythematosus DOI Creative Commons
Yara Roshdy,

Shwikar Mahmoud Ahmed,

Mona Morsi

et al.

Alexandria Journal of Medicine, Journal Year: 2025, Volume and Issue: 61(1), P. 1 - 10

Published: Feb. 6, 2025

Language: Английский

Citations

0

The Role of Infant and Early Childhood Gut Virome in Immunity and the Triggering of Autoimmunity—A Narrative Review DOI Creative Commons
Alexandra Mpakosi, Rozeta Sokou,

Martha Theodoraki

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(4), P. 413 - 413

Published: Feb. 8, 2025

Background: The bacterial gut microbiome has been the subject of many studies that have provided valuable scientific conclusions. However, different populations microorganisms interact with each other to maintain homeostasis coexist inside gut. virome, especially, appears play a key role in this interactive microenvironment. Intestinal viral communities, including bacteriophages, appear influence health and disease, although their not yet fully elucidated. In addition, bacteriophages or viruses infect bacteria regulate growth, thus shaping composition affecting immune system. Infant Gut Virome: during first years life significant maturation infant’s contrast, early dysbiosis associated chronic, metabolic autoimmune, disorders later life. Purpose: Although shown be potential triggers autoimmune diseases, there is gap literature regarding infant virome autoimmunity development. Despite lack evidence, review attempts summarize clarify what known so far about timely important topic hope its findings will contribute future research.

Language: Английский

Citations

0

Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

Citations

0

New thoughts on the gut–immune axis of arthritis DOI
Alexandra Thiran, Lars Vereecke

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0