The avian lung mycobiome: phylogenetic and ecological drivers of lung-fungal communities and their potential pathogens DOI Creative Commons
Paris S. Hamm, Chauncey R. Gadek, Michael Mann

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Vertebrate lungs contain diverse microbial communities, but little is known the causes of community composition or its consequences for health. Lung microbiome assembly by processes such as dispersal, coevolution, and host-switching can be elucidated with comparative surveys. However, few surveys exist lung microbiomes, particularly fungal component, mycobiome. Distinguishing taxa that are generalist specialist symbionts, potential pathogens, incidentally inhaled spores urgent because high emerging disease. Here, we provide first characterization avian mycobiome test relative influences environment, phylogeny, functional traits. We used metabarcoding culturing from 195 samples representing 32 bird species across 20 families. identified 532 (zOTUs) including many opportunistic pathogens. These were composed predominantly phylum Ascomycota (79%) followed Basidiomycota (16%) Mucoromycota (5%). Yeast yeast-like (Malassezia, Filobasidium, Saccharomyces, Meyerozyma, Aureobasidium) filamentous fungi (Cladosporium, Alternaria, Neurospora, Fusarium, Aspergillus) abundant. mycobiomes strongly shaped environmental exposure, further modulated host identity, traits, phylogenetic affinities. Our results implicate migratory vectors long-distance dispersal opportunistically pathogenic fungi.

Language: Английский

Detection of Histoplasma capsulatum in Bats from the Brazilian Western Amazon DOI Creative Commons
Jhonatan Henrique Lima da Rocha, Tamyres Izarelly Barbosa da Silva,

Rair de Sousa Verde

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(4), P. 314 - 314

Published: April 16, 2025

Histoplasma capsulatum is a saprophytic dimorphic fungus that causes histoplasmosis, systemic infectious disease of relevance to public health. Bats can be important agents in the epidemiological cycle since they act as reservoirs microorganisms. The aim this study was detect lung tissue bats captured urban forest fragments municipality Rio Branco, Acre, Western Amazon. Twenty-two bat species were from five fragments. samples taken subjected histopathological, mycological, and molecular analysis. Among 96 animals analyzed, detected 32.29% (31/96). This first pathogen It also record being six species. state Acre located region with rich diversity bats. Furthermore, area constantly suffering climatic environmental changes favor emergence re-emergence diseases. Thus, active research surveillance neglected fungal infections are essential, especially considering concept One Health.

Language: Английский

Citations

0
Phylogenetic and ecological drivers of the avian lung mycobiome and its potentially pathogenic component DOI Creative Commons
Paris S. Hamm, Chauncey R. Gadek, Michael Mann

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 19, 2025

Vertebrate lungs contain diverse microbial communities, but little is known about the drivers of community composition or consequences for health. Microbiome assembly by processes such as dispersal, coevolution, and host-switching can be probed with comparative surveys; however, few studies exist lung microbiomes, particularly fungal component, mycobiome. Distinguishing among taxa that are generalist specialist symbionts, potential pathogens, incidentally inhaled spores urgent because emerging diseases. Here, we characterize avian mycobiome test relative influences environment, phylogeny, functional traits. We used metabarcoding culturing from 195 samples representing 32 bird species across 20 families. identified 526 estimated distinct sequence types (zOTUs) including many opportunistic pathogens. These were predominantly phylum Ascomycota (79%) followed Basidiomycota (16%) Mucoromycota (5%). Yeast yeast-like (Malassezia, Filobasidium, Saccharomyces, Meyerozyma, Aureobasidium) filamentous fungi (Cladosporium, Alternaria, Neurospora, Fusarium, Aspergillus) abundant. Lung mycobiomes strongly shaped environmental exposure, further modulated host identity, traits, phylogenetic affinities. Our results implicate migratory vectors long-distance dispersal opportunistically pathogenic fungi.

Language: Английский

Citations

0
Coccidioidomycosis in Immunocompromised at a Non-Endemic Referral Center in Mexico DOI Creative Commons
Carla Marina Román-Montes,

Lisset Seoane-Hernández,

Rommel Flores-Miranda

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(6), P. 429 - 429

Published: June 18, 2024

The incidence and distribution of coccidioidomycosis are increasing. Information scarcity is evident in Mexico, particularly non-endemic zones specific populations. We compared the treatment outcomes for patients with isolated pulmonary infections those disseminated coccidioidomycosis, including mortality rates within six weeks diagnosis. Of 31 CM cases, 71% were male 55% disseminated. For 42% patients, there was no evidence having lived or visited an endemic region. All had at least one comorbidity, 58% pharmacologic immunosuppressants. general rate 30%; without differences between localized disease. In our research, we describe a high frequency disease risk factors non-significant mortality. Exposure to regions not found considerable number subjects. consider diverse reasons why this may be, such as climate change migration.

Language: Английский

Citations

0
The avian lung mycobiome: phylogenetic and ecological drivers of lung-fungal communities and their potential pathogens DOI Creative Commons
Paris S. Hamm, Chauncey R. Gadek, Michael Mann

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Vertebrate lungs contain diverse microbial communities, but little is known the causes of community composition or its consequences for health. Lung microbiome assembly by processes such as dispersal, coevolution, and host-switching can be elucidated with comparative surveys. However, few surveys exist lung microbiomes, particularly fungal component, mycobiome. Distinguishing taxa that are generalist specialist symbionts, potential pathogens, incidentally inhaled spores urgent because high emerging disease. Here, we provide first characterization avian mycobiome test relative influences environment, phylogeny, functional traits. We used metabarcoding culturing from 195 samples representing 32 bird species across 20 families. identified 532 (zOTUs) including many opportunistic pathogens. These were composed predominantly phylum Ascomycota (79%) followed Basidiomycota (16%) Mucoromycota (5%). Yeast yeast-like (Malassezia, Filobasidium, Saccharomyces, Meyerozyma, Aureobasidium) filamentous fungi (Cladosporium, Alternaria, Neurospora, Fusarium, Aspergillus) abundant. mycobiomes strongly shaped environmental exposure, further modulated host identity, traits, phylogenetic affinities. Our results implicate migratory vectors long-distance dispersal opportunistically pathogenic fungi.

Language: Английский

Citations

0