Healthcare,
Journal Year:
2024,
Volume and Issue:
12(18), P. 1823 - 1823
Published: Sept. 12, 2024
Type
1
diabetes
(T1D)
severely
impairs
metabolic
control
and
can
lead
to
erectile
dysfunction
(ED)
through
hyperglycemia-induced
vascular
damage,
autonomic
neuropathy,
psychological
distress.
This
review
examines
the
role
of
continuous
glucose
monitoring
(CGM)
in
ameliorating
ED
by
addressing
variability
inflammation.
A
comprehensive
analysis
studies
clinical
trials
was
conducted
evaluate
impact
CGM
on
control,
inflammatory
responses,
health
patients
with
T1D.
Evidence
suggests
that
systems
significantly
stabilize
blood
levels
reduce
hyper-
hypoglycemic
episodes
contribute
endothelial
ED.
CGM’s
real-time
feedback
helps
optimize
improve
health,
has
potential
redefine
management
T1D
improving
glycemic
reducing
physiological
stressors
cause
ED,
potentially
quality
life
sexual
health.
Further
research
is
warranted
explore
specific
benefits
for
management.
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: March 18, 2025
Erectile
dysfunction
is
a
common
clinical
condition
that
seriously
affects
the
quality
of
life
and
mental
health
men
their
partners.
Metabolic
syndrome
(MetS)
most
important
public
problem
threatening
men's
worldwide,
its
current
prevalence
continues
to
grow.
This
study
examines
relationship
between
metabolic
erectile
(ED).
We
conducted
cross-sectional
with
data
were
sourced
from
NHANES
2001-2004.
In
this
study,
METS-VF
ED
was
analyzed
using
multivariate
logistic
regression,
followed
by
subgroup
analyses
identify
sensitive
populations.
Comparative
regression
Receiver
Operating
Characteristic
(ROC)
curve
assessed
diagnostic
capability
against
classical
obesity
index
for
ED.
Creating
Predictive
Histograms
Patients
assess
net
benefit
model
through
Decision
Curve
Analysis
(DCA).
The
enrolled
1,374
participants,
whom
545
self-reported
history.
There
significant
positive
association
risk
in
people
2.32
times
higher
than
without
(dominance
ratio
=
2.32,
95%
confidence
interval:
1.83-2.96,
p
<
0.001).
Subgroup
analysis
highlighted
stronger
correlation
participants
aged
50-85
years,
hypertensive
individuals,
those
large
belly
circumference.
A
histogram
including
three
variables:
syndrome,
age
smoking
status
constructed
predict
probability
occurrence.
And
decision
(DCA)
used
nomogram
at
different
high-risk
thresholds.
high
utility
under
thresholds
illustrated.
syndrome.
Furthermore,
observed
emphasizes
need
increased
vigilance
patients
advanced
age,
smoking,
MetS.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3073 - 3073
Published: March 27, 2025
Erectile
dysfunction
(ED)
is
a
prevalent
condition
affecting
male
sexual
health,
characterized
by
the
inability
to
achieve
or
maintain
satisfactory
erections.
ED
has
multifactorial
pathogenesis
in
which
psychological,
hormonal,
neurologic,
cardiovascular,
and
lifestyle
factors
all
contribute
progressive
decline
of
erectile
function.
A
critical
underlying
mechanism
involves
oxidative
stress
(OS),
an
imbalance
between
reactive
oxygen
species
(ROS)
production
antioxidant
defenses,
disrupts
endothelial
function,
reduces
nitric
oxide
(NO)
bioavailability,
contributes
vascular
dysfunction.
This
narrative
review
explores
interplay
OS
ED,
focusing
on
roles
ROS
sources
such
as
NADPH
oxidase,
xanthine
uncoupled
synthase,
mitochondrial
It
examines
impact
chronic
conditions
like
hypertension,
diabetes
mellitus,
hyperlipidemia,
hypogonadism,
smoking
obesity,
exacerbate
through
systemic
effects.
Emerging
research
underscores
potential
therapies
interventions
restore
redox
balance,
improve
mitigate
ED's
progression.
also
highlights
gaps
understanding
molecular
pathways
linking
emphasizing
need
for
further
develop
targeted
therapeutic
strategies.
Lipids in Health and Disease,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Feb. 22, 2024
Abstract
Background
Erectile
dysfunction
(ED)
is
closely
associated
with
dyslipidemia;
however,
it
yet
unknown
how
ED
and
remnant
cholesterol
(RC)
are
related.
As
such,
this
research
sought
to
explore
the
correlation
between
RC
among
individuals
diagnosed
diabetes.
Methods
This
cross-sectional
study
used
information
from
215
males
National
Health
Nutrition
Examination
Survey
(NHANES)
2001
2004.
was
calculated
as
follows:
values
of
high-density
lipoprotein
(HDL-c)
low-density
(LDL-c)
were
subtracted
total
(TC)
value,
while
diagnoses
based
on
self-reports.
Weighted
logistic
regression
analyses
using
both
univariate
multivariate
approaches
conducted
assess
ED.
Results
After
comprehensive
adjustment,
multivariable
models
revealed
a
strong
in
subjects
diabetes
(with
an
odds
ratio
(OR)
7.49
95%
confidence
interval
(CI)
1.98–28.37;
P
=
0.004).
On
categorizing
into
3
grades
(T1-T3),
OR
corresponding
higher
grade
increased.
Despite
results
not
reaching
statistical
significance
upon
categorization,
consistent
statistically
significant
trend
(
for
<
0.05)
observed.
Conclusion
indicated
increased
levels
prevalence
diabetic
males.
may
serve
promising
predictor
However,
additional
studies
required
confirm
these
findings.
ABSTRACT
The
objective
of
this
study
was
to
investigate
the
chemical
composition,
biological
activity,
and
intervention
mechanism
Healthy
Snow
Lotus
Wine
in
treatment
erectile
dysfunction
(ED).
A
preliminary
relative
characterization
quantification
conducted
using
ultra
performance
liquid
chromatography‐quadrupole
orbitrap
mass
spectrometry
(UPLC‐Q‐Orbitrap‐MS).
This
analysis
led
screening
components
that
met
criteria
drug
similarity
bioavailability.
Network
pharmacology
methods
were
utilized
identify
active
ingredients
their
molecular
targets
are
relevant
ED.
Enrichment
revealed
a
significant
association
between
pathways
related
stress,
particularly
those
involved
cellular
basement
membrane
phosphatidylinositol
3‐kinase
complex
signaling.
Molecular
docking
experiments
demonstrated
key
compounds
bind
well
ED‐related
proteins,
including
STAT3,
EGFR,
SRC,
AKT1,
BCL2.
Antioxidant
wine
exhibited
high
antioxidant
capacity,
with
its
total
phenolic
content
(TPC),
flavonoid
(TFC),
proanthocyanidin
(TAC)
being
superior
other
samples.
These
findings
provide
substantial
evidence
support
therapeutic
potential
treating
ED
through
multiple
mechanisms,
underscoring
notable
activity.
Neurourology and Urodynamics,
Journal Year:
2024,
Volume and Issue:
43(6), P. 1261 - 1271
Published: Jan. 4, 2024
Abstract
Introduction
Overactive
bladder
(OAB)
and
Underactive
(UAB)
could
be
associated
with
metabolic
syndrome,
affective
disorders,
sex
hormone
deficiency,
changes
in
urinary
microbiota,
functional
gastrointestinal
or
autonomic
nervous
system
dysfunction.
Objectives
The
aim
of
this
Think
Tank
was
to
provide
a
guide
on
how
investigate
OAB
and/or
detrusor
underactivity
(DU)
patients
better
clarify
the
underlying
pathophysiology
possibly
personalize
treatment.
Methods
A
compendium
discussion
based
current
evidence
related
phenotyping
DU
investigating
metabolic,
neurogical,
psychological
aspects
Results
Conclusions
article
emphasizes
critical
significance
adopting
comprehensive
yet
tailored
approach
lower
tract
symptoms,
such
as
UAB.
intricate
interplay
between
various
factors,
neurological,
psychological,
can
define
unique
LUT
profiles,
enabling
personalized
therapies
replace
one‐size‐fits‐all
approach.
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: March 18, 2024
Background
Erectile
Dysfunction
(ED)
is
a
common
sexual
dysfunction
in
men
who
are
unable
to
consistently
obtain
and
maintain
sufficient
penile
erection
accomplish
satisfactory
life.
ED
currently
considered
be
predictor
of
cardiovascular
disease
(CVD),
but
few
studies
have
observed
the
association
between
clinical
features
coronary
heart
(CHD).
An
investigation
characteristics
CHD
was
carried
out
using
cross-sectional
study
design.
Methods
This
single-center
conducted
Department
Cardiology
included
248
patients.
Associations
patients'
general
information,
underlying
severity
were
statistically
analytically
analyzed
SPSS
26.0
software.
Patients
with
comparable
grouped
together
K-means
clustering.
Finally,
ordered
logistic
regression
analysis
performed
for
information.
Results
In
comparison
data,
age,
education,
weekly
exercise
associated
distribution
severity.
number
diseases,
hypertension,
diabetes,
hyperlipidemia,
anxiety
state,
depressive
state
degree
subtypes,
lesion
sites,
stenoses,
stenosis,
interventional
interventions.
The
time
from
onset
subtypes
stenoses.
We
clustered
main
low-risk
high-risk
patients
found
that
BMI,
smoking,
alcoholism,
depression
all
risk
factors
(
P
<
0.05);
higher
value
above
factors,
more
severe
CHD.
Age
protective
factor
severity;
younger
patient,
lower
likelihood
myocardial
infarction.
Conclusion
may
predictive
Reducing
smoking
alcohol
consumption,
maintaining
healthy
body
weight,
regular
physical
activity
important
preventing
CVD
Journal of Health Population and Nutrition,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Nov. 11, 2024
Erectile
dysfunction
(ED)
is
a
common
issue
among
adult
males.
The
Composite
Dietary
Antioxidant
Index
(CDAI)
reflects
anti-inflammatory
levels
and
has
been
linked
to
various
diseases,
but
its
relationship
with
ED
unclear.