Penile endothelial dysfunction, impaired redox metabolism and blunted mitochondrial bioenergetics in diet-induced obesity: compensatory role of H2O2

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

Erectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health men their partners. Metabolic syndrome (MetS) most important public problem threatening men's worldwide, its current prevalence continues to grow. This study examines relationship between metabolic erectile (ED). We conducted cross-sectional with data were sourced from NHANES 2001-2004. In this study, METS-VF ED was analyzed using multivariate logistic regression, followed by subgroup analyses identify sensitive populations. Comparative regression Receiver Operating Characteristic (ROC) curve assessed diagnostic capability against classical obesity index for ED. Creating Predictive Histograms Patients assess net benefit model through Decision Curve Analysis (DCA). The enrolled 1,374 participants, whom 545 self-reported history. There significant positive association risk in people 2.32 times higher than without (dominance ratio = 2.32, 95% confidence interval: 1.83-2.96, p < 0.001). Subgroup analysis highlighted stronger correlation participants aged 50-85 years, hypertensive individuals, those large belly circumference. A histogram including three variables: syndrome, age smoking status constructed predict probability occurrence. And decision (DCA) used nomogram at different high-risk thresholds. high utility under thresholds illustrated. syndrome. Furthermore, observed emphasizes need increased vigilance patients advanced age, smoking, MetS.

Language: Английский

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Erectile Dysfunction and Oxidative Stress: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3073 - 3073

Published: March 27, 2025

Erectile dysfunction (ED) is a prevalent condition affecting male sexual health, characterized by the inability to achieve or maintain satisfactory erections. ED has multifactorial pathogenesis in which psychological, hormonal, neurologic, cardiovascular, and lifestyle factors all contribute progressive decline of erectile function. A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production antioxidant defenses, disrupts endothelial function, reduces nitric oxide (NO) bioavailability, contributes vascular dysfunction. This narrative review explores interplay OS ED, focusing on roles ROS sources such as NADPH oxidase, xanthine uncoupled synthase, mitochondrial It examines impact chronic conditions like hypertension, diabetes mellitus, hyperlipidemia, hypogonadism, smoking obesity, exacerbate through systemic effects. Emerging research underscores potential therapies interventions restore redox balance, improve mitigate ED's progression. also highlights gaps understanding molecular pathways linking emphasizing need for further develop targeted therapeutic strategies.

Language: Английский

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Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(8), P. 2184 - 2198

Published: Feb. 20, 2024

Language: Английский

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Sexual dysfunction in patients with diabetes: association between remnant cholesterol and erectile dysfunction

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 22, 2024

Abstract Background Erectile dysfunction (ED) is closely associated with dyslipidemia; however, it yet unknown how ED and remnant cholesterol (RC) are related. As such, this research sought to explore the correlation between RC among individuals diagnosed diabetes. Methods This cross-sectional study used information from 215 males National Health Nutrition Examination Survey (NHANES) 2001 2004. was calculated as follows: values of high-density lipoprotein (HDL-c) low-density (LDL-c) were subtracted total (TC) value, while diagnoses based on self-reports. Weighted logistic regression analyses using both univariate multivariate approaches conducted assess ED. Results After comprehensive adjustment, multivariable models revealed a strong in subjects diabetes (with an odds ratio (OR) 7.49 95% confidence interval (CI) 1.98–28.37; P = 0.004). On categorizing into 3 grades (T1-T3), OR corresponding higher grade increased. Despite results not reaching statistical significance upon categorization, consistent statistically significant trend ( for < 0.05) observed. Conclusion indicated increased levels prevalence diabetic males. may serve promising predictor However, additional studies required confirm these findings.

Language: Английский

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Study on the Chemical Composition, Biological Activity, and Mechanism of Intervention in Erectile Dysfunction of Healthy Snow Lotus Wine

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

ABSTRACT The objective of this study was to investigate the chemical composition, biological activity, and intervention mechanism Healthy Snow Lotus Wine in treatment erectile dysfunction (ED). A preliminary relative characterization quantification conducted using ultra performance liquid chromatography‐quadrupole orbitrap mass spectrometry (UPLC‐Q‐Orbitrap‐MS). This analysis led screening components that met criteria drug similarity bioavailability. Network pharmacology methods were utilized identify active ingredients their molecular targets are relevant ED. Enrichment revealed a significant association between pathways related stress, particularly those involved cellular basement membrane phosphatidylinositol 3‐kinase complex signaling. Molecular docking experiments demonstrated key compounds bind well ED‐related proteins, including STAT3, EGFR, SRC, AKT1, BCL2. Antioxidant wine exhibited high antioxidant capacity, with its total phenolic content (TPC), flavonoid (TFC), proanthocyanidin (TAC) being superior other samples. These findings provide substantial evidence support therapeutic potential treating ED through multiple mechanisms, underscoring notable activity.

Language: Английский

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How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI‐RS 2023: Part 1

Neurourology and Urodynamics, Journal Year: 2024, Volume and Issue: 43(6), P. 1261 - 1271

Published: Jan. 4, 2024

Abstract Introduction Overactive bladder (OAB) and Underactive (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal or autonomic nervous system dysfunction. Objectives The aim of this Think Tank was to provide a guide on how investigate OAB and/or detrusor underactivity (DU) patients better clarify the underlying pathophysiology possibly personalize treatment. Methods A compendium discussion based current evidence related phenotyping DU investigating metabolic, neurogical, psychological aspects Results Conclusions article emphasizes critical significance adopting comprehensive yet tailored approach lower tract symptoms, such as UAB. intricate interplay between various factors, neurological, psychological, can define unique LUT profiles, enabling personalized therapies replace one‐size‐fits‐all approach.

Language: Английский

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Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: March 18, 2024

Background Erectile Dysfunction (ED) is a common sexual dysfunction in men who are unable to consistently obtain and maintain sufficient penile erection accomplish satisfactory life. ED currently considered be predictor of cardiovascular disease (CVD), but few studies have observed the association between clinical features coronary heart (CHD). An investigation characteristics CHD was carried out using cross-sectional study design. Methods This single-center conducted Department Cardiology included 248 patients. Associations patients' general information, underlying severity were statistically analytically analyzed SPSS 26.0 software. Patients with comparable grouped together K-means clustering. Finally, ordered logistic regression analysis performed for information. Results In comparison data, age, education, weekly exercise associated distribution severity. number diseases, hypertension, diabetes, hyperlipidemia, anxiety state, depressive state degree subtypes, lesion sites, stenoses, stenosis, interventional interventions. The time from onset subtypes stenoses. We clustered main low-risk high-risk patients found that BMI, smoking, alcoholism, depression all risk factors ( P &lt; 0.05); higher value above factors, more severe CHD. Age protective factor severity; younger patient, lower likelihood myocardial infarction. Conclusion may predictive Reducing smoking alcohol consumption, maintaining healthy body weight, regular physical activity important preventing CVD

Language: Английский

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Pharmacotherapeutic strategies for the management of erectile dysfunction in patients with diabetes and pre-diabetes

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(16), P. 2213 - 2223

Published: Nov. 1, 2024

Introduction Erectile dysfunction (ED) is a neglected complication in patients with pre-diabetes or diabetes mellitus (DM).

Language: Английский

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Association between the composite dietary antioxidant index and erectile dysfunction in US men: a cross-sectional study

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Nov. 11, 2024

Erectile dysfunction (ED) is a common issue among adult males. The Composite Dietary Antioxidant Index (CDAI) reflects anti-inflammatory levels and has been linked to various diseases, but its relationship with ED unclear.

Language: Английский

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