Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Language: Английский
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 22, 2024
Abstract Background Diabetic retinopathy (DR) is the foremost cause of vision loss among global working-age population, and statins are most frequently prescribed drugs for lipid management in patients with DR. The exact relationship between DR has not been determined. This study sought to validate causal association usage diabetic retinopathy. Methods summary-data-based Mendelian randomization (SMR) method inverse-variance-weighted (IVW-MR) were used identify via use expression quantitative trait loci (eQTL) data 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) (31,684 blood samples), low density lipoprotein cholesterol-related GWAS (sample size: 440,546), DR-related (14,584 cases 176,010 controls). Additionally, a cross-sectional observational based on from National Health Nutrition Examination Survey (NHANES) was conducted supplement 106,911). odds ratios (ORs) corresponding 95% confidence intervals (CIs) employed evaluate results. Results Based results MR analysis, HMGCR inhibitors causally connected noticeably greater incidence (IVW: OR = 0.54, CI [0.42, 0.69], p 0.000002; SMR: 0.66, [0.52, 0.84], 0.00073). Subgroup analysis revealed that affected by severity sensitivity stability reliability NHANES also support taking decreased risk (OR [0.37, 0.79], 0.001). Conclusions significant increase related use, providing novel insights into role However, further investigations needed verify these findings.
Language: Английский
Citations
7
Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(3)
Published: March 1, 2024
Abstract Background As the population ages, mild cognitive impairment (MCI) and type 2 diabetes mellitus (T2DM) become common conditions that often coexist. Evidence has shown MCI could lead to reduced treatment compliance, medication management, self‐care ability in T2DM patients. Therefore, early identification of those with increased risk is crucial from a preventive perspective. Given growing utilization decision trees prediction health‐related outcomes, this study aimed identify patients using tree approach. Methods This hospital‐based case–control was performed Endocrinology Department Xiangya Hospital affiliated Central South University between March 2021 December 2022. defined based on Petersen criteria. Demographic characteristics, lifestyle factors, T2DM‐related information were collected. The sample randomly divided into training validation sets 7:3 ratio. Univariate multivariate analyses performed, model established chi‐square automatic interaction detection (CHAID) algorithm key predictor variables associated MCI. area under curve (AUC) value used evaluate performance model, regression also evaluated for comparison. Results A total 1001 participants (705 set 296 set) included study. mean age 60.2 ± 10.3 60.4 9.5 years, respectively. There no significant differences characteristics ( p > .05). CHAID analysis identified six MCI, including age, educational level, household income, regular physical activity, diabetic nephropathy, retinopathy. had 15 nodes composed 4 layers, most variable. It well (AUC = .75 [95% confidence interval (CI): .71–.78] .67 CI: .61–.74] sets, respectively), internally validated, comparable predictive compared logistic .76 .72–.80] .69 .62–.75] respectively). Conclusion retinopathy validated. Due its superior classification accuracy simple presentation as interpretation collected data, more recommended clinical practice.
Language: Английский
Citations
5
Clinical Optometry, Journal Year: 2025, Volume and Issue: Volume 17, P. 3 - 10
Published: Jan. 1, 2025
Diabetic retinopathy (DR) posed an adverse psychological impact among affected individuals. This study evaluates the psychometric of Retinopathy-induced visual impairment: A hospital-based study, Al Buraimi, Sultanate Oman. population having Retinopathy, cross-sectional, included 218 participants diabetic retinopathy. The Vision Quality Life Index (VisQoL) utility questionnaire was used to measure status. Ordinal logistic regression analyses evaluated significant factors from age, gender, acuity, duration DM or DR, responsible for Of participants, 114 (52.29%) were males and 104 (47.71%) females. mean diabetes mellitus (DM) 17.21 ± 6.97 years 5.15 3.51 respectively. score 2.21 1.03. One-third (34.86%), 2.75% extremely concerned, while 33.94% observed have a little concern. Visual impairment status (p = 0.00), higher age DR severity 0.00) individuals lacking support life partner negative impact. Majority had proliferative majority (34.86%) reported no concern, notable percentage (65.14%) expressed minor-to-severe level Age, marital status, predictors their scores.
Language: Английский
Citations
0
Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(5), P. 8 - 8
Published: May 6, 2025
To explore the causal associations among circulating proteins, plasma metabolites, and age-related macular degeneration (AMD). We employed Mendelian randomization (MR) analysis colocalization to discern relationship between proteomes AMD. This investigation utilized data from protein quantitative trait loci (pQTL) studies in deCODE UK Biobank. Additionally, metabolite-related genome-wide association (GWAS) AMD-related GWAS were incorporated. Our findings confirmed a potential cytoplasmic tryptophanyl-tRNA synthetase 1 (WARS1) higher risk of The observed impact WARS1 on two subtypes AMD (dry wet) align consistently with aforementioned outcomes. Three metabolites-N-acetyl-kynurenine, N-acetyltyrosine, caproate (6:0)-were identified as mediators effect AMD, subgroup revealed that N-acetyltyrosine is specific negative metabolite associated dry whereas X-16580 positive linked wet outcomes this study suggest role proteins mediating metabolites by integrating multiple genetic analyses. Nevertheless, further research essential validate strengthen these conclusions. establishes
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 30, 2024
Background Pancreatitis is a serious and complex inflammatory disease that imposes severe effect on quality of life. Links between plasma lipidome pancreatitis have been reported, some which not yet clearly elucidated. Methods Therefore, our study aimed to investigate the causal relationships four types by conducting bidirectional, two-sample Mendelian randomization (MR) analysis. We obtained genetic variants associated with 179 lipid species from Genome-wide association analysis lipidome. The aggregated statistical data acute (AP), alcohol-induced (AAP), chronic (CP), (ACP) FinnGen consortium were exploited as outcome. inverse variance weighted (IVW) technique main method was used for MR sensitivity analyses evaluate heterogeneity pleiotropy. Results After FDR correction, SE (27:1/20:4) (OR = 0.938, 95%CI 0.906-0.972, P 4.38 × 10 -4 , PFDR 0.039) identified be significantly AP risk. Eight CP risk: 0.911, 0.869-0.954, 8.89 -5 0.016), LPC (20:4) 0.892, 0.843-0.945, 9.74 0.009), PC (16:0_22:5) 0.880, 0.818-0.947, 6.29 0.028), (17:0_20:4) 0.893, 0.842-0.948, 1.76 0.010), (18:0_20:4) 0.920, 0.874-0.969, 1.70 -3 0.038), (O-16:0/20:4) 0.871, 0.804-0.943, 6.95 0.025), (O-16:1/20:4) 0.890, 0.832-0.953, 7.85 0.023), PE (O-18:1/20:4) 0.866, 0.791-0.947, 1.61 0.041). Furthermore, genetically predicted increased 0.862, 0.796-0.934, 3.00 0.027) SM (34:2;O2) 0.753, 0.659-0.860, 2.97 0.005) levels decreased risk ACP. Conclusions Our findings provide evidence associations specific pancreatitis, offering new insights into future clinical research.
Language: Английский
Citations
2
Advances in Ophthalmology Practice and Research, Journal Year: 2024, Volume and Issue: 5(1), P. 32 - 40
Published: Oct. 11, 2024
The association between myopia and diabetic retinopathy (DR) is unclear, with inconsistent results reported, whether the represents causality remains unknown. This study aimed to investigate causal associations of genetically determined DR, further explore specific mechanisms. We conducted two-sample mendelian randomization (MR) analyses any high on six DR phenotypes, including background severe proliferative (PDR), maculopathy unspecific in primary study. Mechanism exploration spherical equivalent refraction (SER), corneal curvature (CC) axial length (AL) was carried out subsequently. Single-nucleotide polymorphisms (SNPs), used as genetic instruments, were derived from UK Biobank, Genetic Epidemiology Research Adult Health Aging cohort (GERA) FinnGen. inverse variance weighted (IVW) method mainly assess causality, complemented sensitivity direction analyses. Using SNPs that have excluded possible confounders, we discovered suggestive positive (IVW: odds ratio [OR] = 1.133, 95% confidence interval [95%CI]: 1.070-1.201, P 1.91×10-5) PDR OR 1.182, CI: 1.088-1.285, 8.31×10-5). Similar but more significant found 1.107, 95%CI: 1.051-1.166, 1.39×10-4; 1.163, 1.088-1.244, 8.76×10-6, respectively). Further mechanism only AL, rather than SER or CC, strongly significantly associated DR. These robust risk PDR, which might be related indicating significance control for preventing development progression.
Language: Английский
Citations
1
Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Language: Английский
Citations
0