Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study DOI Creative Commons
Mahsa Noroozzadeh, Maryam Mousavi, Marzieh Saei Ghare Naz

et al.

Reproductive Biology and Endocrinology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 22, 2025

Genetic factors and an unfavorable intrauterine environment may contribute to the development of metabolic disorders in offspring later life. The present study aims investigate compare risks pre-diabetes mellitus (pre-DM), type 2 diabetes (T2DM) abnormal glucose tolerance female male with early maternal menopausal age versus those normal age, In this prospective population-based study, there were 1,516 females 1,563 males as well 213 237 age. Unadjusted adjusted cox regression models used assess hazard ratios (HRs) 95% confidence intervals (CIs) for association between pre-DM, T2DM offspring. Statistical analysis was performed using STATA software package; significance level set at P < 0.05. revealed a higher risk pre-DM compared (unadjusted HR (95% CI): 1.42 (0.98, 2.05); = 0.06 (marginal significant) 1.47 (1.00, 2.16); 0.04). Additionally, among model observed (HR 1.13 (0.99-1.29); 0.06, marginal significant). However, no significant differences developing both unadjusted models. No difference This pioneering characterized by long-term follow-up, demonstrated that is associated increased It be advisable implement screening metabolism these Not applicable.

Language: Английский

Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study DOI Creative Commons
Mahsa Noroozzadeh, Maryam Mousavi, Marzieh Saei Ghare Naz

et al.

Reproductive Biology and Endocrinology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 22, 2025

Genetic factors and an unfavorable intrauterine environment may contribute to the development of metabolic disorders in offspring later life. The present study aims investigate compare risks pre-diabetes mellitus (pre-DM), type 2 diabetes (T2DM) abnormal glucose tolerance female male with early maternal menopausal age versus those normal age, In this prospective population-based study, there were 1,516 females 1,563 males as well 213 237 age. Unadjusted adjusted cox regression models used assess hazard ratios (HRs) 95% confidence intervals (CIs) for association between pre-DM, T2DM offspring. Statistical analysis was performed using STATA software package; significance level set at P < 0.05. revealed a higher risk pre-DM compared (unadjusted HR (95% CI): 1.42 (0.98, 2.05); = 0.06 (marginal significant) 1.47 (1.00, 2.16); 0.04). Additionally, among model observed (HR 1.13 (0.99-1.29); 0.06, marginal significant). However, no significant differences developing both unadjusted models. No difference This pioneering characterized by long-term follow-up, demonstrated that is associated increased It be advisable implement screening metabolism these Not applicable.

Language: Английский

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