Editorial: Challenges in pediatric endocrinology regarding alterations in glucose metabolism, growth disorders, disorders of sex development, and puberty in adolescents DOI Creative Commons
Giulio Maltoni, Egidio Candela, Gianluca Tornese

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 3, 2025

While a relatively established field of study, pediatric endocrinology has witnessed significant acceleration in acquiring advanced and nuanced knowledge recent years. This rapid progress stems from breakthroughs genetics, integration machine learning, enhanced understanding the microbiome human biology, advancements laboratory methodologies, novel therapeutic options [1,2]Building on this line present research topic concentrated applying integrative approach to studying idiopathic central precocious puberty (CPP) type 1 diabetes mellitus (T1DM), two well-recognized conditions that remain incompletely understood.An excellent example new frontier is issue addressed by meta-analysis Yung-Yi Lan et al., whose results highlight high diagnostic accuracy achieved learning models utilizing clinical, hormonal (laboratory), imaging data for diagnosing CPP, with impressive sensitivity, specificity, area under curve (AUC) values, showcasing their potential improving precision. Genetic influences timing are also gaining prominence. For instance, an extensive multi-ancestry genetic analysis ~800,000 women identified 1,080 signals associated age at menarche, suggesting while genetically driven CPP remains minority, identification role increasing [3-4]. The study Weiqin Li al. particularly noteworthy. It developed integrated predictive model early pubertal development (EPD) girls, incorporating factors (28 single-nucleotide polymorphisms, SNPs) non-genetic (e.g., overweight, lifestyle habits). Interestingly, proved be more impactful prediction, indicating need holistic assessing EPD risk. Equally intriguing work conducted Yuanxiao Ying which assessed effects mechanistic targets rapamycin (mTOR)- dependent circulating protein levels CPP. Mendelian randomization analyses causal association between plasma one these proteins, eIF4G, onset, its as biomarker prevention or treatment. Wen Jiang explored clinical aspects less commonly studied, such ophthalmic evaluations. Using Objective Scatter Index (OSI), alterations estrogen levels, opening avenues into systemic CPP.The T1DM highlights another critical endocrinology. example, Limin Wang revealed distinct microbiological characteristics oropharyngeal gut microbiota children T1DM, including metabolic pathways related amino acid fatty metabolism. These findings relevant given showing adolescents who received probiotics exhibited poorer glycemic control than controls. counterintuitive result warrants further investigation complex interplay outcomes [5].The review takes broader perspective, focusing age-specific challenges management, emphasizing interaction physical, psychological, social factors. proposes practical strategies tailored different developmental stages, offering actionable insights clinicians.Fedorczak colleagues' sirtuin (SIRT1) growth Their indicate dietary factors, fruit vegetable intake, influence SIRT1 significantly biological variables, like stage. nutrition, health, growth, providing foundation future research.The studies presented Research Topic illustrate how leveraging multidisciplinary approaches, research, can drive advances emphasize personalized collaboration address complexities T1DM. Further required validate emerging biomarkers integrate technologies practice, paving way improved outcomes.

Language: Английский

Editorial: Challenges in pediatric endocrinology regarding alterations in glucose metabolism, growth disorders, disorders of sex development, and puberty in adolescents DOI Creative Commons
Giulio Maltoni, Egidio Candela, Gianluca Tornese

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 3, 2025

While a relatively established field of study, pediatric endocrinology has witnessed significant acceleration in acquiring advanced and nuanced knowledge recent years. This rapid progress stems from breakthroughs genetics, integration machine learning, enhanced understanding the microbiome human biology, advancements laboratory methodologies, novel therapeutic options [1,2]Building on this line present research topic concentrated applying integrative approach to studying idiopathic central precocious puberty (CPP) type 1 diabetes mellitus (T1DM), two well-recognized conditions that remain incompletely understood.An excellent example new frontier is issue addressed by meta-analysis Yung-Yi Lan et al., whose results highlight high diagnostic accuracy achieved learning models utilizing clinical, hormonal (laboratory), imaging data for diagnosing CPP, with impressive sensitivity, specificity, area under curve (AUC) values, showcasing their potential improving precision. Genetic influences timing are also gaining prominence. For instance, an extensive multi-ancestry genetic analysis ~800,000 women identified 1,080 signals associated age at menarche, suggesting while genetically driven CPP remains minority, identification role increasing [3-4]. The study Weiqin Li al. particularly noteworthy. It developed integrated predictive model early pubertal development (EPD) girls, incorporating factors (28 single-nucleotide polymorphisms, SNPs) non-genetic (e.g., overweight, lifestyle habits). Interestingly, proved be more impactful prediction, indicating need holistic assessing EPD risk. Equally intriguing work conducted Yuanxiao Ying which assessed effects mechanistic targets rapamycin (mTOR)- dependent circulating protein levels CPP. Mendelian randomization analyses causal association between plasma one these proteins, eIF4G, onset, its as biomarker prevention or treatment. Wen Jiang explored clinical aspects less commonly studied, such ophthalmic evaluations. Using Objective Scatter Index (OSI), alterations estrogen levels, opening avenues into systemic CPP.The T1DM highlights another critical endocrinology. example, Limin Wang revealed distinct microbiological characteristics oropharyngeal gut microbiota children T1DM, including metabolic pathways related amino acid fatty metabolism. These findings relevant given showing adolescents who received probiotics exhibited poorer glycemic control than controls. counterintuitive result warrants further investigation complex interplay outcomes [5].The review takes broader perspective, focusing age-specific challenges management, emphasizing interaction physical, psychological, social factors. proposes practical strategies tailored different developmental stages, offering actionable insights clinicians.Fedorczak colleagues' sirtuin (SIRT1) growth Their indicate dietary factors, fruit vegetable intake, influence SIRT1 significantly biological variables, like stage. nutrition, health, growth, providing foundation future research.The studies presented Research Topic illustrate how leveraging multidisciplinary approaches, research, can drive advances emphasize personalized collaboration address complexities T1DM. Further required validate emerging biomarkers integrate technologies practice, paving way improved outcomes.

Language: Английский

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