Clinical pharmacology and therapy, Journal Year: 2023, Volume and Issue: 32(4)
Published: Nov. 4, 2023
Tixagevimab/cilgavimab (
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 761 - 761
Published: Jan. 24, 2025
Membranous nephropathy is a glomerular disease that may be caused by exogenous risk factors in genetically predisposed individuals (primary MN) or associated with other autoimmune diseases, drug exposure, cytotoxic agents (secondary MN). Primary membranous (PMN) an which antigens—mainly the phospholipase A2 receptor—are located podocytes and are targeted circulating antibodies, leading to situ formation of immune complexes activate complement system. Clinically, characterized nephrotic syndrome (NS) complications. The outcome PMN can vary, but untreated patients NS progress end-stage kidney (ESKD) 35–40% cases within 10 years. Treatment primarily aims prevent complications progression ESKD. most commonly used immunosuppressive drugs rituximab, corticosteroids, cyclophosphamide, calcineurin inhibitors. Most experience improvement proteinuria, sometimes followed relapse. Fewer than 50% achieve complete stable remission. In addition therapy, antiproteinuric, anti-lipemic, anticoagulant medicaments often required.
Language: Английский
Citations
1
Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
ABSTRACT Despite high levels of global concern, little is known about the epidemiology Clostridioides ( Clostridium ) difficile infection (CDI) in Cambodia. This study aimed to identify prevalence and risk factors for CDI, molecular types C. hospitalized adults at Calmette Hospital, Phnom Penh, Stool samples were collected from 263 between June September 2022 tested using direct enrichment cultures. PCR toxin genes tcdA, tcdB, cdtA , cdtB, amplification 16s–23s rRNA intergenic spacer region ribotyping, performed on all isolates. was isolated 24% (63/263) samples, most isolates non-toxigenic (67%, 42/63). The five predominant toxigenic ribotypes (RTs) RTs 046 (8%, 5/63), 017 (6%, 4/63), 056 (5%, 3/63), 014/020 012 (3%, 2/63), prominent QX011 (14%, 9/63), 010 009 QX021 QX002 2/63). Risk significantly associated with CDI included diabetes (odds ratio [OR] = 2.48, 95% confidence interval [CI]: 1.16–5.30) hospitalization >24 h within last 3 months before testing (OR 3.89, CI: 1.79–8.43). It concluded that participants whom colonized only; however, a asymptomatic carriage could contribute silent transmission healthcare settings communities. Genotypic identification local strains necessary better understanding importance . IMPORTANCE significant cause diarrhea worldwide, initially as hospital-acquired and, more recently, community-associated infection. include antimicrobial consumption, extended hospitalization, age ≥ 65 years, proton pump inhibitor treatment. While much high-income countries, there has been less interest this Asia due lack data. Thus, investigating characterizing Asian countries such Diabetes identified colonization/infection. country notable. Further studies are warranted gain insights into
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 459 - 459
Published: Jan. 27, 2025
Background/Objectives: Children on dialysis have a 10-fold increase in cardiovascular disease (CVD)-related mortality when compared to the general population. The development of CVD patients is attributed Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD) and dyslipidemia. While prevalence dyslipidemia adult has been described, there are limited data prevalence, severity, risk factors for pediatric Methods: Data from 1730 ≤ 21 years receiving maintenance hemodialysis or peritoneal with at least one lipid panel measurement were obtained USRDS between 2001 2016. Disease etiology was classified as being glomerular (n = 1029) non-glomerular 701). Comparisons made across etiologies using both linear logistic regression models determine relationship levels. Results: cohort had mean age 15.2 54.5% female. Adjusting age, sex, race/ethnicity, modality, time End Stage (ESKD), body mass index (BMI) reference, [mean (95% CI)] associated +19% (+14.7%, +23.8%) higher total cholesterol level (183 mg/dL vs. 162 mg/dL), +21% (+14.8%, +26.6%) low density lipoprotein (108 87 +22.3% (+15.5%, +29.5%) triglyceride (169 147 mg/dL). Glomerular [OR 3.0-fold [2.4, 3.9] odds having an abnormal level, 3.8-fold [2.8, 5.0] LDL-C 1.9-fold [1.5, 2.4] disease. Conclusions: Pediatric high dyslipidemia, particularly elevated Specifically, even non-HDL levels than long-term impact this unfavorable profile requires further investigation.
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120206 - 120206
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Glomerulonephritis (GN), one of the primary causes chronic kidney disease (CKD), is gaining recognition as a major public health issue. This research sought to evaluate worldwide impact due glomerulonephritis (GN-CKD) between 1990 and 2021 forecast trends up 2036, leveraging data from Global Burden Disease (GBD) study. The analysis GN-CKD utilized GBD open secondary dataset examine global prevalence, deaths, disability-adjusted life years (DALYs), age-standardized rates GN-CKD, changing these indicators were statistically analyzed. To assess practical difference each country/region frontier, we DALYs Socio-Demographic Index (SDI). assist healthcare institutions in formulating more effective policies, mortality rate until 2036 predicted using Bayesian age-period-cohort (BAPC) modeling techniques. prevalence indicated by (ASPR), grew 10.81% 2021, with marginal average annual change 0.04 (AAPC0.04, 0.03-0.05). Similarly, there was an increase 15.84% death (ASDR) for during this period, trend 0.50 (AAPC0.50, 0.41-0.59). Moreover, (ASYR) observed upward 8.60% modest 0.27 (AAPC0.27, 0.17-0.37). Our findings indicate that differs across gender, geographic areas, socioeconomic statuses. Elevated fasting plasma glucose levels, high body-mass index (BMI), elevated systolic blood pressure main contributors deaths (DALYs). Fortunately, burden expected diminish 2036. has risen, variations genders SDI regions. Encouraging point toward potential reduction GN-CKD-related future.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 14, 2025
Language: Английский
Citations
0
Nephrology, Journal Year: 2025, Volume and Issue: 30(4)
Published: April 1, 2025
ABSTRACT We report the case of a 38‐year‐old Caucasian man with well‐controlled HIV on antiretroviral therapy who developed nephrotic syndrome. The patient presented maculopapular rash, lymphadenopathy, oral lesions, nasal congestion and bilateral pitting oedema. Laboratory tests revealed hypoalbuminemia, range proteinuria abnormal liver function. Further investigations confirmed secondary syphilis positive Treponema pallidum serology. Kidney biopsy showed membranous nephropathy. Treatment Benzathine benzylpenicillin resulted in rapid resolution syndrome, improved function normalisation serum albumin levels. This highlights rare but recognised link between emphasising importance prompt diagnosis antibiotic treatment to prevent need for more aggressive treatments. Syphilis can cause variety systemic manifestations, co‐infection is common due their shared transmission route. Healthcare providers must remain vigilant considering as potential syndrome HIV‐positive patients, particularly when other clinical laboratory features suggest its presence.
Language: Английский
Citations
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Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: May 1, 2025
Pediatric nephrotic syndrome remains a complex clinical entity, with incompletely elucidated pathogenetic mechanisms, in which oxidative stress appears to have substantial etiopathogenic role. Recent evidence supports the involvement of redox imbalance podocyte damage, impaired glomerular function, and systemic decline. All this suggests that antioxidant interventions can favorably modulate course disease. This narrative review aims synthesize most relevant data from current literature on interaction between children, focus therapeutic potential antioxidants. The analysis focuses molecular mechanisms by contributes progression renal dysfunction, role biomarkers disease monitoring, ability antioxidants reduce need for immunosuppressants corticosteroids, thus contributing decrease associated morbidity. translational perspectives therapy are also discussed, context urgent effective adjuvant strategies safety profile superior conventional therapies. By integrating these data, paper valorization as an emerging direction management pediatric substantiates controlled trials, rigorous design, field.
Language: Английский
Citations
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Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: May 22, 2025
Language: Английский
Citations
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Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 455 - 455
Published: Feb. 18, 2024
The nephrotic syndrome holds significant clinical importance and is characterized by a substantial protein loss in the urine. Damage to glomerular basement membrane or podocytes frequently underlies renal loss. There an increasing belief involvement of complement system, part innate immune these conditions. Understanding interactions between system structures continually evolves, challenging traditional view blood–urine barrier as passive filter. Clinical studies suggest that precise inhibition at various points may soon become feasible. However, thorough understanding current knowledge imperative for planning future therapies diseases such membranous glomerulopathy, membranoproliferative glomerulonephritis, lupus nephritis, focal segmental glomerulosclerosis, minimal change disease. This review provides overview its with structures, insights into specific exhibiting course. Additionally, we explore new diagnostic tools therapeutic approaches.
Language: Английский
Citations
2