Multifunctional MXene-Based Platforms for Soft and Bone Tissue Regeneration and Engineering

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(4), P. 1892 - 1909

Published: March 11, 2024

MXenes and their composites hold great promise in the field of soft bone tissue regeneration engineering (TRE). However, there are challenges that need to be overcome, such as ensuring biocompatibility controlling morphologies MXene-based scaffolds. The future prospects TRE include enhancing through surface modifications, developing multifunctional constructs, conducting vivo studies for clinical translation. purpose this perspective about is critically evaluate potential applications contributions field. This aims provide a comprehensive analysis challenges, advantages, limitations, associated with use TRE. By examining existing literature research, review seeks consolidate current knowledge highlight key findings advancements It contribute understanding MXenes' role promoting TRE, addressing faced terms biocompatibility, morphology control, interactions.

Language: Английский

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Nano-Innovations in Cancer Therapy: The Unparalleled Potential of MXene Conjugates

Materials, Journal Year: 2024, Volume and Issue: 17(6), P. 1423 - 1423

Published: March 20, 2024

MXenes are two-dimensional transition metal carbides, nitrides, and carbonitrides that have become important materials in nanotechnology because of their remarkable mechanical, electrical, thermal characteristics. This review emphasizes how crucial MXene conjugates for several biomedical applications, especially the field cancer. These (2D) nanoconjugates with photothermal, chemotherapeutic, photodynamic activities demonstrated promise highly effective noninvasive anticancer therapy. conjugates, distinctive optical capabilities, been employed bioimaging biosensing, excellent light-to-heat conversion efficiency makes them perfect biocompatible notably proficient nanoscale agents photothermal applications. The synthesis characterization provide a framework an in-depth understanding various fabrication techniques importance customized formation conjugates. following sections explore MXene-based nanotheranostics demonstrate enormous potential Nanoconjugates, such as polymers, metals, graphene, hydrogels, biomimetics, quantum dots, radio exhibit unique properties can be used therapeutic diagnostic applications cancer nanotheranostics. An additional layer into safety concerns is provided by detailing toxicity viewpoints. Furthermore, concludes addressing opportunities challenges clinical translation nanoconjugates, emphasizing real-world medical practices.

Language: Английский

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Research progress in the application of MXene in bacterial detection and eradication

Materials Today Physics, Journal Year: 2024, Volume and Issue: 43, P. 101412 - 101412

Published: March 26, 2024

Language: Английский

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Exploring the synergistic potential of MXene-MOF hybrid composites: A perspective on synthesis, properties, and applications

Hybrid Advances, Journal Year: 2023, Volume and Issue: 5, P. 100131 - 100131

Published: Dec. 19, 2023

Hybrid composites incorporating MXenes and metal-organic frameworks (MOFs) have emerged as highly promising materials across diverse domains, encompassing photocatalysis, electrocatalysis, optoelectronics, nanotechnology, biomedicine. These composite boast exceptional properties showcase synergistic effects, resulting in augmented performance the exploration of novel applications. The amalgamation MXene MOF components confers several advantages, including elevated surface area, tunable porosity, superb electrical conductivity, chemical stability. inherent attributes empower MXene-MOF hybrids to manifest enhanced catalytic activity, facilitate efficient charge transfer, exhibit improved optical properties. Notably, these hybrid hold tremendous promise addressing global challenges such energy conversion storage, environmental remediation, biomedical unique versatility position them ideal candidates for development sustainable innovative solutions. Despite their immense potential, persist, scalability, production costs, long-term stability, imperative further optimization synthesis processes. In this review article, we aim illuminate strategies employed crafting hybrids, concurrently exploring distinctive that render exceptionally well-suited a broad array Furthermore, accentuates burgeoning applications underscoring potential spearhead technological advancements various disciplines. Through nuanced methodologies detailed examination properties, seeks contribute deeper understanding thereby fostering judicious utilization pursuit cutting-edge innovations.

Language: Английский

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Simultaneous antioxidant and neuroprotective effects of two-dimensional (2D) MXene-loaded isoquercetin for ischemic stroke treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2795 - 2806

Published: Jan. 1, 2024

Oxidative stress and reactive oxygen species drive ischemic stroke its related complications. New antioxidant medications are therefore crucial for treating stroke. We developed Ti2C@BSA-ISO nanocomposites loaded with the hydrophobic drug isoquercetin (ISO) encapsulated in BSA on Ti2C nano-enzymes as a novel therapeutic nanomedicine treatment of targeting (ROS). TEM visually proved successful preparation Ti2C@BSA-ISO, FTIR, XPS, zeta potential DLS together demonstrated acquisition Ti2C@BSA-ISO. In addition, enzyme-mimicking activity was evaluated capacity verified. able to reverse decrease cellular caused by ROS. Experiments vivo showed that could promote neuroprotection scavenging ROS hippocampal CA1 area cerebral cortex rats, thereby inhibiting death alleviating ischaemic Specifically, alleviated NLRP3/caspase-1/GSDMD pathway-mediated pyroptosis. Our study demonstrates effectiveness nanomedicines can be directly used drugs synergy other drugs, which greatly expands application nanomaterials

Language: Английский

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