International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113582 - 113582
Published: Nov. 12, 2024
Language: Английский
Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103568 - 103568
Published: Feb. 26, 2025
Reactive oxygen species (ROS) are chemical moieties that in physiological concentrations serve as fast-acting signaling molecules important for cellular homeostasis. However, their excess either due to overproduction or inability of the antioxidant system inactivate them results oxidative stress, contributing dysfunction and tissue damage. In tendons, which hypovascular, hypocellular, composed predominantly extracellular matrix (ECM), particularly collagen I, ROS likely play a dual role: regulating processes such inflammation, proliferation, ECM remodeling under conditions, while tendinopathy impaired healing when dysregulated. This review explores sources including NADPH oxidases mitochondria, role key adaptation mechanical load injury repair, also systemic conditions diabetes. addition, we integrate emerging perspective calcium signaling-mediated by mechanically activated ion channels-plays central tendon mechanotransduction daily loads. We propose overuse (overload) may lead hyperactivation channels, resulting chronically elevated intracellular levels amplify production stress. Although direct evidence linking channel hyperactivity, dysregulation, generation overload is currently circumstantial, this aims highlight these connections identify critical avenues future research. By framing within context both adaptive maladaptive responses load, provides comprehensive synthesis redox biology paving way work, development therapeutic strategies targeting enhance recovery resilience.
Language: Английский
Citations
0
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2024, Volume and Issue: 18(36), P. 24803 - 24811
Published: Aug. 23, 2024
The preparation of artificial diamonds has a long history driven by decreased costs compared to naturally occurring and ethical issues. However, fabrication in the laboratory from readily available biomass not been extensively investigated. This work demonstrates convenient method for producing nanodiamonds biopolymer lignin at ambient pressure. Lignin was extracted Douglas Fir sawdust using butanosolv pretreatment pyrolyzed N2 1000 °C, followed second thermal treatment 5% H2/Ar 1050 both led formation embedded an amorphous carbon substrate. changes various stages pyrolysis process were monitored scanning electron microscopy, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy. High resolution transmission microscopy revealed that nanodiamond crystallites, 4 nm diameter on average, formed via multiple nucleation events some carbon-containing high density spheres. It is proposed highly defected graphene-like flakes form during as intermediate phase. These are more deformable with localized π electrons comparison graphene join together face-to-face different manners cubic or hexagonal nanodiamonds. mechanism relevant future under relatively mild conditions.
Language: Английский
Citations
2
Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11
Published: June 24, 2024
Both acute and chronic tendon injuries are the most frequently occurring musculoskeletal diseases in human veterinary medicine, with a limited repertoire of successful evidenced-based therapeutic strategies. Inflammation has been suggested as key driver for formation scar adhesion tissue following injury, well pathological alternations degenerative tendinopathy. However, prior efforts to completely block this inflammatory process have yet be largely successful. Recent investigations indicated that more precise targeted approach modulating inflammation is critical improve outcomes. The nuclear factor-kappaB (NF-κB) typical proinflammatory signal transduction pathway identified factor leading disorders. Therefore, comprehensive understanding mechanism or regulation NF-κB disorders will aid developing strategies In review, we discuss what currently known about molecular components structures basal proteins two activation pathways: canonical non-canonical pathway. Furthermore, summarize underlying mechanisms signaling fibrosis after changes tendinopathy all species highlight effect targeting gain its disorders, further required. future, extensive scientific examinations warranted full characterize NF-κB, exact action, translate findings into clinical practice.
Language: Английский
Citations
1
Deleted Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113582 - 113582
Published: Nov. 12, 2024
Language: Английский
Citations
0