Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 504, P. 158713 - 158713
Published: Dec. 17, 2024
Language: Английский
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Abstract Hydrogel microspheres are important in regenerative medicine and tissue engineering, acting as cargos of cells, drugs, growth factors, bio‐inks for 3D printing, medical devices. The antimicrobial anti‐inflammatory characteristics hydrogel good treating injured tissues. However, the biological properties should be modified optimal treatment various body parts with different physiological biochemical environments. In addition, specific preparation methods required to produce customized shapes sizes clinical applications. Herein, advances biomedical applications reviewed. Synthesis precursor solutions, manufacturing methods, strategies enhancing functions these described. involvement bioactive repair is also discussed. This review anticipates fostering more insights into design, production, application biomedicine.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 24, 2025
Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with MSCs-derived promoting healing. We modify the RHC methacrylate anhydride (MA) at optimal concentration, generating (RHCMA) ideal physiochemical properties exosome delivery (MSC-exos@RHCMA). Exosomes derived from adipose-derived MSCs (ADSC-exos), bone marrow-derived (BMSC-exos) umbilical cord (ucMSC-exos) are harvested culture supernatants loaded into RHCMA, respectively. These three systems exhibit desired sustained release features, can significantly improve cell proliferation migration. In addition, these MSC-exos@RHCMAs show excellent performance treating wounds of rats. Notably, demonstrated that healing effect occurs best under treatment ucMSC-exos@RHCMA, following inflammatory resolution, angiogenesis, formation. results would supply important clinical application MSC-exos future.
Language: Английский
Citations
0
Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102701 - 102701
Published: April 3, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162309 - 162309
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 16, 2025
Diabetes mellitus is a prevalent chronic disease, often leading to complications, with wounds being among the most challenging. Impairment of CXCR4/CXCL12 signaling pathway, which plays key role in cell mobilization, migration, and angiogenesis, significantly hampers wound healing process diabetic patients. Modulation this pathway using CXCR4-targeted agents has shown promise restoring repair capabilities. Additionally, development responsive hydrogels capable adapting external stimuli offers powerful platform for drug delivery management. These hydrogels, when loaded CXCR4 agonists or antagonists, enable controlled release real-time therapeutic modulation. Integrating such existing strategies may provide an innovative effective solution overcoming challenges associated treatment.
Language: Английский
Citations
0
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)
Published: Nov. 11, 2024
Dynamic structural colors can change in response to different environmental stimuli. This ability remains effective even when the size of species responsible for color is reduced a few micrometers, providing promising sensing mechanism solving microenvironmental problems micro-robotics and microfluidics. However, lack dynamic that encode rapidly, easily integrate, accurately reflect changes physical quantities hinders their use microscale applications. Herein, we present 2.5-dimensional based on nanogratings heterogeneous materials, which were obtained by interweaving pH-responsive hydrogel with an IP-L photoresist. Transverse gratings printed hydrogels elongated period longitudinal grating swollen state, resulting pH-tuned at 45° incidence. Moreover, patterned encoding array printing achieved using grayscale stripe images periods heights nanogrid structures. Overall, networks exhibit potential applications information encryption situ microfluidic chips.
Language: Английский
Citations
2
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Abstract The traditional fabrication of opal‐structured photonic crystals is constrained by the rate solvent evaporation, a process that not only time‐consuming but also labor‐intensive. This study introduces paradigm shift incorporating silica nanoparticles (SiNPs) with high zeta potentials and hydrogen bonding capabilities into an elastomeric matrix, resulting in novel non‐close‐packed structure. innovation circumvents limitations conventional methods enabling rapid formation inks (PI) vibrant luminous elastomers (PEs) within seconds. These PEs demonstrate remarkable mechanochromic properties, exhibiting dynamic color changes across visible spectrum response to tensile compressive deformations. Furthermore, presence hydroxyl groups endows superior water‐responsiveness, which can be finely tuned through ink formulation. elimination evaporation dependency facilitates macroscopic crystal devices complex geometries using digital light processing (DLP)‐based 3D printing. approach ensures exceptional optical performance customization potential. hold significant promise for applications smart wearables, soft robotics, advanced human‐machine interface technologies.
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(47), P. 65480 - 65488
Published: Nov. 15, 2024
Advanced multifunctional optical films or substrates have continued to develop as essential components in the diverse industry. Several functions, including high transparency, self-cleaning ability, structural color, flexibility, and durability, are required obtain versatile practical films. Herein, we introduce a cicada-wing-inspired transfunctional thin film (CITOTF) with nanostructures on both surface inspired by cicada-wings. CITOTFs made of perfluoropolyether (PFPE), which has low refractive index, energy, robustness substrate material, obtained well-designed sandwich lithography method. We fabricated two types depending size (300 1000 nm) nanostructure. 300-CITOTF 1000-CITOTF exhibit transparency color effects, respectively. Both samples demonstrate long-term stability. The bioinspired developed this study can be used various applications.
Language: Английский
Citations
0
Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3451 - 3451
Published: Dec. 10, 2024
Biological tissue defects are typically characterized by various shaped defects, and they prone to inflammation the excessive accumulation of reactive oxygen species. Therefore, it is still urgent develop functional materials which can fully occupy adhere irregularly injection promote repair process using antioxidant anti-inflammatory mechanisms. Herein, in this work, phenylboronic acid modified oxidized hyaluronic (OHAPBA) was synthesized dynamically crosslinked with catechol group glycol chitosan (GCHCA) guar gum (GG) into a hydrogel loaded curcumin liposomes (Cur-LPs) were relatively uniformly distributed around 180 nm. The possessed rapid gelation within 30 s, outstanding injectability tissue-adaptive properties self-healing properties, ability biological tissues adapt movement. Moreover, good biocompatibility higher DPPH scavenging efficiency illustrated hydrogel. And more sustainable release from Cur-LPs-loaded hydrogels, could last for 10 days, achieved improve bioavailability curcumin. Finally, might be injected mechanisms sustained anti-inflammation. would have potential application as candidates defect repair.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 504, P. 158713 - 158713
Published: Dec. 17, 2024
Language: Английский
Citations
0