Published: Aug. 13, 2024
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115519 - 115519
Published: Feb. 1, 2025
Language: Английский
Citations
2
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 7, 2025
Language: Английский
Citations
0
BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 11, 2025
An effective and appropriate method to support the ankle joint optimally is particularly important during healing phase of fractures. The purpose this review was assess functional outcomes, ankle-related quality life, associated complications cast immobilization versus removable braces for treatment adult Studies comparing after fracture were included by systematic searches PubMed/MEDLINE, Web Science, Scopus, EMBASE databases according PRISMA (Preferred Reporting Items Systematic Evaluation Meta-Analysis Statements) guidelines. Primary outcome measures early mid-late Olerud Molander Ankle Score (OMAS). Secondary outcomes dorsiflexion plantarflexion, swelling, pain, time return work, calf muscle atrophy, complications. Subgroup analysis performed. Risk bias assessed in both randomized controlled trials cohort studies. Eleven studies including 1485 patients met eligibility criteria. types study Weber A/B/C Lauge-Hansen supination external rotation (SER), supination-adduction (SA), pronation-external (PER) pronation-abduction (PA). results meta-analysis showed that had better (mean difference (MD) -2.14; 95% confidence interval (CI) -4.26, 0.00) mid-term (MD -5.81; CI -10.35, -1.27) compared with immobilization. In addition, caused significantly more wound breakdown (Odds ratio (OR) 0.39; 0.17, 0.90) infections (OR 0.32; 0.58) than Compared immobilization, periods fractures less likely result deep vein thrombosis (DVT). Overall, brace a comfortable option might improve outcomes.
Language: Английский
Citations
0
Theranostics, Journal Year: 2025, Volume and Issue: 15(9), P. 4135 - 4146
Published: March 10, 2025
Rationale: Osteoarthritis (OA) is a chronic joint disorder with limited treatment efficacy, necessitating innovative therapeutic strategies. This study explores one-pot-synthesized gelatin microspheres devoid of glutaraldehyde as novel biomaterial for OA management. Focusing on the Ext1 gene, critical cartilage development and downregulated in OA, we investigated its restoration immune regulation using cultured mesenchymal stem cells (MSCs). Methods: patients undergoing knee replacement surgery have their lateral compartment (remote zone) medial (lesion collected transcriptomic testing. The differential gene identified, expression regulatory genes examined. MSCs were to evaluate compatibility ability promote cell attachment. effects overexpression, regulation, symptom mitigation through vitro vivo experiments. Results: exhibit decreased area, accompanied by abnormal genes. demonstrated that exhibited excellent facilitated Culturing led enhanced overexpression which crucial growth development. Additionally, regulated responses, contributing reduction symptoms. Conclusion: introduces an strategy osteoarthritis MSCs. By promoting regulating these effectively mitigate findings highlight potential this promising option OA.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Tendon repair remains challenging owing to the limited capacity for endogenous repair. Vasoactive intestinal peptide (VIP) promotes bone tissue regeneration; however, its role in tendon unclear. In present study, we demonstrated that VIP stimulated M2 polarization of macrophages and facilitated regeneration by regulating immune homeostasis maintaining function stem/progenitor cells (TSPCs). Additionally, established GelMa-loaded VIP@PLGA@ZIF-8 (VPZ) nanoparticles (VPZG) enable sustained localized release at site patellar injury SD rats. The results vitro experiments VPZG regulated macrophage downregulating NF-κB axis. also promoted efferocytosis suppressed proinflammatory factors. enhanced tenogenic differentiation TSPCs when cocultured with macrophages. vivo, implanted injury, where it released sustainably slowly promote regeneration. This effect was achieved through downregulation expression levels various inflammatory factors, as well regulation local homeostasis. conclusion, our enhancing TSPC function. These findings suggest is a promising avenue clinical improvement treatment.
Language: Английский
Citations
0
Published: April 3, 2025
ABSTRACT Magnetic continuum robots (MCRs) have garnered substantial attention as a new class of flexible robotic systems capable navigating complex and confined spaces with remarkable dexterity. By combining continuous, deformable structures remotely applied magnetic fields, MCRs achieve contactless, remote manipulation, making them well‐suited for medical applications. This review introduces recent advances in MCR research, focusing on design principles, structural configurations, control strategies. Various designs structures, including those integrated permanent magnets, matter, ferromagnetic sphere, micro coil, are discussed. Furthermore, different actuation platforms introduced, the level automation is classified based Key intelligent manipulation capabilities MCRs, navigation, delivery, printing, grasping, imaging, sensing explored. Finally, future development priorities directions identified to provide insights advancing systems.
Language: Английский
Citations
0
eScience, Journal Year: 2025, Volume and Issue: unknown, P. 100409 - 100409
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
ABSTRACT In this study, four thermal damage assessment methods were used to investigate the caused by femtosecond lasers on skin tissues. Collagen volume and texture characteristic parameters of microstructure calculated analyzed Masson staining samples grayscale covariance matrix. The degree protein denaturation Arrhenius equation Raman spectroscopy. results show that as laser power increases or scanning speed decreases, collagen tissue angular second‐order moments correlations increase, entropy value contrast decrease, intensity peak spectral bands spectrum in regions 1 4 increases, which indicates increases.
Language: Английский
Citations
0
Published: Aug. 13, 2024
Language: Английский
Citations
0