Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 708 - 708

Published: March 21, 2025

The rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development innovative therapeutic strategies overcome these challenges. Copper-based nanomaterials have emerged as promising agents due their intrinsic antibacterial properties, cost-effectiveness, and adaptability for multifunctional approaches. These materials exhibit exceptional potential in advanced therapies, including chemodynamic therapy (CDT), photothermal (PTT), photodynamic (PDT). Their unique physicochemical such controlled ion release, reactive oxygen species (ROS) generation, tunable catalytic activity, enable them target MDR effectively while minimizing off-target effects. This paper systematically reviews mechanisms through which Cu-based enhance efficiency emphasizes specific performance field. Key factors influencing properties—such electronic interactions, characteristics, size effects, ligand single-atom doping, geometric configurations—are analyzed depth. By uncovering copper-based nanomaterials, this work aims inspire approaches that improve patient outcomes, reduce burden bacterial infections, health initiatives.

Language: Английский

Fluorescence Turn-On Sensing of Leucine Using Bimetallic Cu–Ag Nanoclusters: A Potential Non-Invasive Biomarker for Cancer Detection

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

This study investigates the use of bimetallic copper-silver nanoclusters (Cu-AgNCs) for fluorescence turn-on sensing leucine, a potential biomarker cancer detection. These exhibit high tunability and specificity, with Fe3+ serving as quencher to facilitate leucine The recovery mechanism is attributed interaction Fe3+, alleviating quenching effect on metal nanoclusters. nanocluster promising platform identification in diagnosis. enhancement upon binding provides measurable signal, confirming feasibility these noninvasive sensors biomarkers. sensor achieves detection limit 0.58 μM demonstrates linear response within range 110-657 μM. approach offers method diagnostics using saliva urine samples. Additionally, method's reproducibility robustness further support its clinical applications, providing cost-effective accessible technique early

Language: Английский

Fluorescence ‘turn-on’ sensing of glial fibrillary acidic protein using graphene oxide-quenched copper nanoclusters

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)

Published: March 26, 2025

Language: Английский