Amphiphilic Janus Nanoparticles for a Superhydrophobic Coating on the Enamel Surface to Prevent Caries

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101627 - 101627

Published: March 6, 2025

Bacteria are pivotal in the etiology of dental caries, underscoring critical importance effective plaque control mitigating tissue diseases. Superhydrophobic materials, with their exceptional properties non-wettability, antibacterial activity, and self-cleaning capabilities, present a promising approach for caries prevention. However, clinical application remains constrained by challenges achieving stable adhesion to tooth surfaces. Inspired natural mechanisms acquired salivary pellicle (ASP), we synthesized Janus amphiphilic superhydrophobic nanoparticles comprising 1H,1H,2H,2H-perfluorooctyltriethoxysilane (FOTS), nano-silica, enamel binding peptide DDDEEKC-Peg(2000)-COOH. These were engineered form film (FOTS-SiO2-Peptide) on Experimental analyses revealed rapid adsorption these onto enamel, exposed surfaces creating durable layer that remained under diverse thermal conditions. Topical FOTS-SiO2-Peptide significantly reduced incidence severity while preserving oral microbiota diversity avoiding adverse effects surrounding mucosal tissues. Safety efficacy evaluations confirmed biocompatibility nanoparticles, highlighting potential as novel biomedical solution

Language: Английский

Editorial: special topic on biomedical materials

Science China Materials, Journal Year: 2024, Volume and Issue: 67(12), P. 3761 - 3762

Published: Nov. 12, 2024

Language: Английский

Mussel-inspired novel coating with cariogenic biofilm inhibition and in situ remineralization properties for caries treatment

Materials Advances, Journal Year: 2024, Volume and Issue: 6(3), P. 1067 - 1074

Published: Dec. 25, 2024

A facile and dual-functional PDA@PC hybrid coating, prepared via the Michael addition Schiff base reactions, exhibits remarkable performance in terms of antibiofilm activity remineralization capabilities for dental caries management.

Language: Английский