Development of Vancomycin, a Glycopeptide Antibiotic, in a Suitable Nanoform for Oral Delivery DOI Creative Commons
Asem A. Amer, Lewis Bingle, Cheng Chaw

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1624 - 1624

Published: April 5, 2025

Bacterial infections caused by resistant strains have emerged as one of the most significant life-threatening challenges. Developing alternatives to conventional antibiotic formulations is crucial overcoming these Vancomycin HCl (VCM) a glycopeptide used for Gram-positive bacterial that must be given intravenously systemic since it cannot pass through gut wall due its chemical structure and characteristics. The aim this research develop VCM in niosomal nanoform then encapsulated fast-disintegrating oral films effective delivery enhance application vancomycin-loaded niosomes treating dental treatments. formulation encapsulating was conducted with various ratios Span 40, 60, cholesterol well Kolliphor RH40 ELP co-surfactants using microfluidic technique. prepared were characterised dynamic light scattering (DLS) their size determination; high-pressure liquid chromatography, HPLC, drug encapsulation efficiency agar diffusion method determination antibacterial efficacy against Bacillus subtilis. incorporated into polyvinyl alcohol (PVA) film, properties film vitro assays. produced optimal conditions exhibited small diameter acceptable polydispersity index, efficiency. This study presents multifunctional loaded VCM, which demonstrated efficient activity bacteria upon slow release from niosomes, dissolution test. Oral containing uniform weights excellent flexibility high foldability rapid disintegration time 105 ± 12 s content. showed approach could encapsulate peptide salt form, surfactant-based vesicles narrow distribution. incorporation provides non-invasive patient-friendly alternative cavity, making promising applications.

Language: Английский

Niosomes as a Targeted Drug Delivery system in the Treatment of Breast Cancer: Preparation, Classification, and Mechanisms of Cellular Uptake DOI

Muneeb UrRahman,

Hafiz Rashid Hussain,

Huzaifa Akram

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: Feb. 18, 2025

Breast cancer remains one of the significant health issues across globe, being diagnosed in millions women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, novel delivery systems formed from non-ionic surfactants, with or without cholesterol charge-inducing agents, are used as treating BC. Their formulation by various methods enhances efficacy bioavailability minimizes side effects. Niosomal tamoxifen exhibits target enhanced stability, whereas docetaxel methotrexate show sustained controlled release, respectively.5-Fluorouracil, doxorubicin, paclitaxel, cyclophosphamide, epirubicin improved cytotoxic against BC when combined other agents. Furthermore, repurposed niosomal formulations anti-cancer drugs penetration, reduced tumor volume, significantly anti-tumor effect. This review article focuses on composition niosomes application treatment then examines how could contribute research.

Language: Английский

Citations

0
Development of Vancomycin, a Glycopeptide Antibiotic, in a Suitable Nanoform for Oral Delivery DOI Creative Commons
Asem A. Amer, Lewis Bingle, Cheng Chaw

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1624 - 1624

Published: April 5, 2025

Bacterial infections caused by resistant strains have emerged as one of the most significant life-threatening challenges. Developing alternatives to conventional antibiotic formulations is crucial overcoming these Vancomycin HCl (VCM) a glycopeptide used for Gram-positive bacterial that must be given intravenously systemic since it cannot pass through gut wall due its chemical structure and characteristics. The aim this research develop VCM in niosomal nanoform then encapsulated fast-disintegrating oral films effective delivery enhance application vancomycin-loaded niosomes treating dental treatments. formulation encapsulating was conducted with various ratios Span 40, 60, cholesterol well Kolliphor RH40 ELP co-surfactants using microfluidic technique. prepared were characterised dynamic light scattering (DLS) their size determination; high-pressure liquid chromatography, HPLC, drug encapsulation efficiency agar diffusion method determination antibacterial efficacy against Bacillus subtilis. incorporated into polyvinyl alcohol (PVA) film, properties film vitro assays. produced optimal conditions exhibited small diameter acceptable polydispersity index, efficiency. This study presents multifunctional loaded VCM, which demonstrated efficient activity bacteria upon slow release from niosomes, dissolution test. Oral containing uniform weights excellent flexibility high foldability rapid disintegration time 105 ± 12 s content. showed approach could encapsulate peptide salt form, surfactant-based vesicles narrow distribution. incorporation provides non-invasive patient-friendly alternative cavity, making promising applications.

Language: Английский

Citations

0