Oxidative Free-Radical C(sp2)–H Bond Chlorination of Enaminones with LiCl: Access to Highly Functionalized α-Chlorinated Enaminones
Yunhua Xie,
No information about this author
Zhilai Zhang,
No information about this author
Biao Zhang
No information about this author
et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8521 - 8530
Published: June 3, 2024
An
oxidative
free-radical
C(sp2)–H
bond
chlorination
strategy
of
enaminones
has
been
developed
by
using
LiCl
as
a
chlorinating
reagent
and
K2S2O8
an
oxidant.
This
transformation
provides
new
straightforward
synthetic
methodology
to
afford
highly
functionalized
α-chlorinated
with
Z-configuration
in
good
excellent
yields.
Language: Английский
Additive-Free Construction of Tetrahydropyrimidine Skeleton by using 1,3,5-Triazinane as Four-Atom Synthon
Lanlan Rong,
No information about this author
Jingwen Ma,
No information about this author
Chenru Lai
No information about this author
et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(13), P. 9496 - 9501
Published: June 18, 2024
Herein,
an
unprecedented
[4
+
2]
cycloaddition
of
enaminone
with
1,3,5-triazinane
has
been
developed.
The
representative
semihydrogenated
aromatic
heterocycle
1,2,3,4-tetrahydropyrimidines
have
synthesized
a
broad
substrate
scope,
demonstrating
potential
antitumor
activity.
This
approach
smoothly
conducted
under
additive-free
and
environmentally
friendly
conditions
that
are
compatible
various
functional
groups.
Furthermore,
the
condition
optimization
process
reveals
tetrahydropyrimidine
product
is
regulated
via
reaction
temperature.
Language: Английский
Iron-Catalyzed [2+1+2+1] Annulation of Amines and N,N-Dimethyl Enaminones using N,N-Dimethylaminoethanol as a One-Carbon Synthon for the Synthesis of 1,4-Dihydropyridines
Jianyong Yuan,
No information about this author
Wanqian Ma,
No information about this author
Qiulin Kuang
No information about this author
et al.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(12), P. 1932 - 1940
Published: Jan. 9, 2024
Abstract
A
simple
and
efficient
method
for
the
synthesis
of
1,4-dihydropyridines
from
amines,
N,N-dimethyl
enaminone
N,N-dimethylaminoethanol
in
a
four-component
[2+1+2+1]
annulation
catalyzed
by
FeCl3
has
been
established,
where
was
applied
as
methine
source.
The
procedure
executed
smoothly,
resulting
wide
range
with
moderate
to
good
yields.
Additionally,
these
fluorophores
exhibited
photophysical
characteristics.
Language: Английский
DBU‐Promoted Solvent‐Free One‐Pot Multicomponent Synthesis of 2‐Amino‐1,4‐Dihydropyridines From β‐Enaminones, Aromatic Aldehydes and Malononitrile
Saikrishna Chintha,
No information about this author
Nagaraju Medishetti,
No information about this author
Maneesha Karangi
No information about this author
et al.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(28)
Published: July 23, 2024
Abstract
The
synthesis
of
2‐amino‐1,4‐dihydropyridines
was
accomplished
starting
from
β‐enaminones,
aromatic
aldehydes
and
malononitrile
with
DBU
without
solvent.
reaction
proceeds
through
a
Knoevenegel
condensation,
which
affords
the
benzylidine
olefin
intermediate.
This
can
directly
react
β‐enaminone,
leading
to
desired
product.
Simple
conditions
no
solvent
good
yields
are
advantages
this
protocol.
Language: Английский
Montmorillonite K-10 catalyzed synthesis of Hantzsch dihydropyridine derivatives from methyl arenes via in situ generated ammonia under microwave irradiation in neat conditions
Vishal Singh,
No information about this author
Khushbu Rajput,
No information about this author
Sundaram Singh
No information about this author
et al.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(37), P. 27086 - 27091
Published: Jan. 1, 2024
Solvent-free
synthesis
of
Hantzsch
1,4-dihydropyridine
catalyzed
by
montmorillonite
K-10
involves
oxidation
methyl
arenes
and
in
situ
-generated
ammonia
from
urea
hydrogen
peroxide
under
microwave
irradiation.
Language: Английский
Nucleophilic Dearomatization of Activated Pyridines Using Vinyl Sulfoxonium Ylides: Application to the Synthesis of Bis-Heterocycles
Srashti Bhardwaj,
No information about this author
Dinesh Kumar Gopalakrishnan,
No information about this author
Tarak Karmakar
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 5, 2024
A
highly
efficient
method
has
been
developed
for
synthesizing
4-dienyl
dihydropyridines
through
the
nucleophilic
dearomatization
of
activated
pyridines
using
vinyl
sulfoxonium
ylides.
This
reaction
follows
sequence
involving
ylide
addition
to
pyridine,
[2,3]-sigmatropic
rearrangement,
and
subsequent
sulfenic
acid
elimination.
The
resulting
are
then
used
in
synthesis
substituted
bis-heterocyles.
Control
experiments
quantum
chemical
calculations
were
conducted
elucidate
selectivity
mechanistic
pathway.
Language: Английский
Photocatalyzed Selective Hydrocarbonation of Alkenes with Hantzsch Esters toward 4-Alkyl-Hantzsch Esters
Shiqin Qiu,
No information about this author
Huaixuan Guo,
No information about this author
Peng Xu
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(31), P. 6730 - 6735
Published: July 30, 2024
Here,
we
describe
a
mild
photoredox-neutral
reaction
system
that
enables
the
selective
hydrocarbonation
of
alkenes
with
Hantzsch
esters,
affording
structurally
diverse
4-alkyl-Hantzsch
esters.
This
straightforward
protocol
can
be
performed
under
an
air
atmosphere
without
need
for
any
transition
metals.
The
synthetic
potential
this
method
is
well
exemplified
by
late-stage
structural
modification
series
pharmaceutically
relevant
complex
molecules.
Language: Английский