An Activity-Based Near-Infrared (Nir) Fluorogenic Probe for Labeling Lysosomal Β-Hexosaminidase in Cells DOI
Injae Shin, Yujun Kim, Changhee Lee

et al.

Published: Jan. 1, 2024

Language: Английский

Novel coumarin-thiazolidine-2,4-dione hybrids as potential α-glucosidase inhibitors: Synthesis and bioactivity evaluation DOI

Bingwen Liang,

Jianping Li,

Simin Wu

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140481 - 140481

Published: Oct. 1, 2024

Language: Английский

Citations

4
Chemical Proteomic Profiling Reveals Prostaglandin Termination Enzyme PTGR2 as a Key Molecular Target of Natural Coumarin Fraxetin DOI

Songyao Kang,

Zhiwei Cai, Yuqing Wang

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Natural coumarins represent a diverse group of secondary metabolites with wide range biological activities. However, their specific molecular targets have remained largely unexplored. Employing chemical proteomics, comprehensive analysis the protein natural coumarin fraxetin has been conducted. Prostaglandin reductase 2 (PTGR2), key enzyme involved in final inactivation prostaglandins, was identified as primary target fraxetin. Inhibition PTGR2 can lead to accumulation 15-keto-PGE2, which subsequently activates Nrf2 signaling pathway and suppresses NF-κB, resulting notable anti-inflammatory effects. These findings provide novel insights into other coumarins, are crucial for fully exploring therapeutic potential.

Language: Английский

Citations

0
A chitosan-based sensing membrane for on-site and sensitive dual-channel portable detection and efficient adsorption of Pb2+ in groundwater DOI
Shuangshuang Liu, Yueyue Wang, Xinyue Chang

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1340, P. 343638 - 343638

Published: Jan. 10, 2025

Language: Английский

Citations

0
Structural characterization, theoretical, and antibacterial activity study of halogen-η3-allylpalladium(II) complexes incorporating 2-, 3- and 4-pyridyl-methylen-4-methylumbelliferone esters DOI

Willyfredo Fragoso–Soto,

Diego Martínez‐Otero,

Irais Sánchez-Orteg

et al.

Polyhedron, Journal Year: 2025, Volume and Issue: unknown, P. 117414 - 117414

Published: Jan. 1, 2025

Language: Английский

Citations

0
CO/CO₂ as C1 building blocks: Unveiling new horizons in coumarin synthesis DOI
Zechao Wang, Jiajia Mou, Hao Jia

et al.

Molecular Catalysis, Journal Year: 2025, Volume and Issue: 574, P. 114887 - 114887

Published: Jan. 30, 2025

Language: Английский

Citations

0
Dual Relaxant Effect of Coumarin‐3‐carboxamides Through the NO/cGMP Pathway and Ca2+ Channels Blockade DOI Open Access

Arabelly Jiménez-Rodríguez,

Cuauhtémoc Alvarado‐Sánchez,

Manuel Velasco

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

We aimed to determine the relaxant pathway of seventeen synthetic compounds derived from coumarin-3-carboxamide. An isolated rat aorta assay was used. To vasorelaxant mode action, receptor blockers and specific enzyme inhibitors involved in endothelial smooth muscle signaling pathways were The 2, 4, 5 showed higher activity than other compounds. N-nitro-L-arginine methyl ester (10 µM) methylene blue significantly inhibited effect (p ≤ 0.05), but not tetraethylammonium (5 mM), indomethacin µM), or atropine (1 µM). abated contraction induced by CaCl2. exert a relaxing through nitric oxide/cyclic guanosine monophosphate activation blocking Ca2+ channels cell membrane. These findings propose coumarin-3-carboxamides as new drug entities with potential develop non-clinical clinical.

Language: Английский

Citations

0
Green preparation of cu immobilized on CaZnFe2O4 MNPs (CaZnFe2O4@OLE-cu) as a biocatalyst in the synthesis of new coumarin derivatives DOI Creative Commons

Masoumeh Pouryavar,

Akbar Mobinikhaledi,

Najmieh Ahadi

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102161 - 102161

Published: Feb. 1, 2025

Language: Английский

Citations

0
An activity-based near-infrared (NIR) fluorogenic probe for labeling lysosomal β-hexosaminidase in cells DOI Creative Commons

Y.I. Kim,

Changhee Lee, Joo Hee Choi

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 433, P. 137519 - 137519

Published: Feb. 28, 2025

Language: Английский

Citations

0
Coumarin-Based Arylpyrazolines: Highly Selective Cu2+ Fluorescent Probes and their AIEE and MFC Properties DOI
Lin Zhang,

R.-Q. Xie,

Weiguang Zhao

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

0
A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of Viola yedoensis Makino DOI Creative Commons
Shuang Wang, Congcong Shen,

Shengyu Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1922 - 1922

Published: April 25, 2025

Viola yedoensis Makino (V. yedoensis), a perennial herb in the Violaceae family, is recognized for its violet flowers and has longstanding role ethnomedicine treating various inflammatory diseases, such as boils, furuncles, carbuncles, both acute chronic hepatitis, among others. A comprehensive literature review was conducted utilizing resources including Chinese Pharmacopoeia, Flora of China, Web Science, PubMed, Baidu Scholar, Google China National Knowledge Infrastructure (CNKI). This paper serves inaugural latest findings regarding botany, traditional applications, phytochemistry, pharmacological properties, quality control, prospective uses V. yedoensis. The objective to provide robust foundation future research suggest novel avenues exploring potential applications. To date, 162 chemical constituents have been isolated from yedoensis, with flavonoids coumarins identified particularly abundant. These compounds exhibit promising activities, anti-inflammatory, anti-pyretic, anti-viral, anti-tumor, anti-lung injury, anti-liver anti-bacterial, anti-coagulant, anti-complement, anti-oxidant properties. Despite considerable advancements fundamental on further investigations are required elucidate underlying mechanisms action discover additional uncharacterized compounds. underscores plant’s significant development potential, highlighting necessity more in-depth exploration.

Language: Английский

Citations

0