Green and Biogenic Synthesis of Cerium Oxide (CeO2) Nanoparticles: Heterogeneous Catalytic Synthesis of Isoxazol‐5(4H)‐one Derivatives and Assessment of Their Antibacterial Activity DOI

Pranali Hadole,

Sudip Mondal,

Sampat Shingda

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(18)

Published: May 1, 2025

Abstract The development of eco‐friendly, sustainable, and efficient catalytic systems has become a highly attractive area research for promoting heterogeneous organic reactions. In this study, we report the use cerium oxide nanoparticles (CeO₂ NPs) as catalyst one‐pot synthesis isoxazol‐5(4H)‐one derivatives. CeO₂ NPs were synthesized via an environmentally benign method using extract from Holy Basil (Ocimum sanctum), offering green, cost‐effective approach. This green not only minimizes hazardous chemicals but also enhances physiochemical properties NPs, including their performance. activity was evaluated through reactions involving variety aldehydes, hydroxylamine hydrochloride, β‐dicarbonyl compounds. A wide range derivatives obtained with excellent yields high purity under mild conditions. Furthermore, reusability thoroughly investigated, demonstrating minimal loss over multiple reaction cycles. study highlights promising sustainable synthesizing valuable heterocyclic compounds nanotechnology, thereby contributing significantly to advancement responsible practices in synthetic chemistry. Moreover, antibacterial further emphasize significance green‐synthesized NPs.

Language: Английский

Exploring magnetically recoverable catalysts for the synthesis of benzoxazoles derivatives DOI Creative Commons

Fadhel F. Sead,

Jayanti Makasana,

Shelesh krishna saraswat

et al.

Applied Catalysis O Open, Journal Year: 2025, Volume and Issue: unknown, P. 207031 - 207031

Published: Feb. 1, 2025

Language: Английский

Citations

0
Design, Synthesis, and Biological Evaluation of Benzo[d]oxazole-2-thio and Oxazolo[4,5-b]pyridine-2-thio Derivatives: Molecular Docking, POM Analysis, In Silico Pharmacokinetics, and Pharmacophore Insights for Antitumor, GPCR, and Kinase Targets DOI
Pankaj B. Gour, Sumeer Ahmed,

Ramalingam Gajendhiran

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141705 - 141705

Published: Feb. 1, 2025

Language: Английский

Citations

0
Anti-Cancer Activity and Molecular Docking of Some Benzoxazole Derivatives as Apoptosis Inducers in Non-Small Cell Lung Cancer DOI
Burcu Baba,

Çağla Zübeyde Köprü,

İlkay Yıldız

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Sustainable Synthesis of Novel 2-(3,4-Disubstituted phenyl)benzoxazole Derivatives and Their Antiproliferative and Antibacterial Evaluation DOI Creative Commons

Anja Rakas,

Leentje Persoons, Dirk Daelemans

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1767 - 1767

Published: April 15, 2025

This study describes the synthesis of O-alkylated benzaldehydes 1–8, Schiff bases 9–28, and benzoxazole derivatives 29–48 using microwave, ultrasound, mechanochemical reactions, as well reactions in deep eutectic solvents excellent yields, their antiproliferative antibacterial activities. The vitro evaluation activity for newly synthesised against a diverse panel human cancer cell lines, such LN-229, Capan-1, HCT-116, NCI-H460, DND-41, HL-60, K-562, Z-138 demonstrated that majority these displayed promising anticancer activity, particularly non-small lung (NSCLC) cells (NCI-H460). Notably, several showed enhanced compared to included reference drug, etoposide. Considering influence substituents at position 5 ring positions 3 4 phenyl on it is evident 41–48 bearing methoxy group generally exhibit higher compounds 29–40, which lack substitution 3. Furthermore, substituted with morpholine substituent, those an N,N-diethyl group, exhibited other evaluated derivatives. Gram-positive Gram-negative bacteria revealed derivative 47 notable bacterium Pseudomonas aeruginosa (MIC = 0.25 μg/mL) Enterococcus faecalis 0.5 μg/mL). results point out this class benzoxazoles can be efficiently synthesized eco-friendly methods represent candidates further design optimization aimed developing potent agents.

Language: Английский

Citations

0
Green and Biogenic Synthesis of Cerium Oxide (CeO2) Nanoparticles: Heterogeneous Catalytic Synthesis of Isoxazol‐5(4H)‐one Derivatives and Assessment of Their Antibacterial Activity DOI

Pranali Hadole,

Sudip Mondal,

Sampat Shingda

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(18)

Published: May 1, 2025

Abstract The development of eco‐friendly, sustainable, and efficient catalytic systems has become a highly attractive area research for promoting heterogeneous organic reactions. In this study, we report the use cerium oxide nanoparticles (CeO₂ NPs) as catalyst one‐pot synthesis isoxazol‐5(4H)‐one derivatives. CeO₂ NPs were synthesized via an environmentally benign method using extract from Holy Basil (Ocimum sanctum), offering green, cost‐effective approach. This green not only minimizes hazardous chemicals but also enhances physiochemical properties NPs, including their performance. activity was evaluated through reactions involving variety aldehydes, hydroxylamine hydrochloride, β‐dicarbonyl compounds. A wide range derivatives obtained with excellent yields high purity under mild conditions. Furthermore, reusability thoroughly investigated, demonstrating minimal loss over multiple reaction cycles. study highlights promising sustainable synthesizing valuable heterocyclic compounds nanotechnology, thereby contributing significantly to advancement responsible practices in synthetic chemistry. Moreover, antibacterial further emphasize significance green‐synthesized NPs.

Language: Английский

Citations

0