Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(3)

Published: March 1, 2025

ABSTRACT Cancer is one of the leading causes cancer‐related deaths worldwide and also among most common malignant tumors digestive system. With decreasing age onset, there an urgent need to develop effective therapeutic strategies improve patient survival. RAN‐binding protein 9 (RANBP9) has been identified as oncogene involved in several cancers, including colon cancer, gastric lung cancer. It plays a crucial role inhibiting tumor metastasis enhancing chemotherapy sensitivity. In this study, we synthesized novel two‐dimensional layered coordination polymer, CP1, by reacting Co(NO 3 ) 2 ·6H O, HL, NH(CN) under solvothermal conditions at 120°C. The compound crystallizes monoclinic C2/m space group, with its asymmetric unit containing two Co(II) ions, half N(CN) − ligands, HL ligand. ions coordinate ligands form one‐dimensional chain, which further interconnected structure. These layers interdigitate through van der Waals interactions, resulting three‐dimensional supramolecular framework (CP1). To enhance drug delivery effects, I was encapsulated within conductive polymer PEDOP (poly(3,4‐ethylenedioxythiophene)) along CP1. PEDOP, well‐known highly stable, making it ideal candidate for systems. PEDOP‐CP1@I nanocarrier significantly inhibited cellular activity HT29 colorectal cancer (CRC) cells, upregulated RANBP9 expression, modulated expression apoptosis‐related genes Bax Bcl‐2, thereby inducing apoptosis CRC cells. findings highlight potential promising strategy therapy.

Language: Английский