The gut‐brain axis in individuals with alcohol use disorder: An exploratory study of associations among clinical symptoms, brain morphometry, and the gut microbiome DOI Creative Commons
Katherine A. Maki, Gwenyth R. Wallen, Thomaz F. S. Bastiaanssen

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 48(7), P. 1261 - 1277

Published: June 22, 2024

Alcohol use disorder (AUD) is commonly associated with distressing psychological symptoms. Pathologic changes AUD have been described in both the gut microbiome and brain, but mechanisms underlying gut-brain signaling individuals are unknown. This study examined associations among microbiome, brain morphometry, clinical symptoms treatment-seeking AUD.

Language: Английский

Bugs as features (part 1): concepts and foundations for the compositional data analysis of the microbiome–gut–brain axis DOI Open Access
Thomaz F. S. Bastiaanssen, Thomas P. Quinn, Amy Loughman

et al.

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(12), P. 930 - 938

Published: Dec. 5, 2023

Language: Английский

Citations

26
The chiPower transformation: a valid alternative to logratio transformations in compositional data analysis DOI
Michael Greenacre

Advances in Data Analysis and Classification, Journal Year: 2024, Volume and Issue: 18(3), P. 769 - 796

Published: Aug. 1, 2024

Language: Английский

Citations

3
Bugs as Features (Part I): Concepts and Foundations for the Compositional Data Analysis of the Microbiome-Gut-Brain Axis DOI Creative Commons
Thomaz F. S. Bastiaanssen, Thomas P. Quinn, Amy Loughman

et al.

arXiv (Cornell University), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 1, 2022

There has been a growing acknowledgement of the involvement gut microbiome - collection microbes that reside in our regulating mood and behaviour. This phenomenon is referred to as microbiome-gut-brain axis. While techniques measure presence abundance these have steadily improving, analysis data non-trivial. Here, we present perspective on concepts foundations interpretation experiments with focus axis domain. We give an overview foundational considerations prior commencing alongside core approaches alpha diversity, beta differential feature functional inference. emphasize compositional (CoDA) paradigm. Further, this features extensive heavily annotated R supplementary materials, resource for new experienced bioinformaticians alike.

Language: Английский

Citations

9
The gut‐brain axis in individuals with alcohol use disorder: An exploratory study of associations among clinical symptoms, brain morphometry, and the gut microbiome DOI Creative Commons
Katherine A. Maki, Gwenyth R. Wallen, Thomaz F. S. Bastiaanssen

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 48(7), P. 1261 - 1277

Published: June 22, 2024

Alcohol use disorder (AUD) is commonly associated with distressing psychological symptoms. Pathologic changes AUD have been described in both the gut microbiome and brain, but mechanisms underlying gut-brain signaling individuals are unknown. This study examined associations among microbiome, brain morphometry, clinical symptoms treatment-seeking AUD.

Language: Английский

Citations

0