Chemical Engineering and Processing - Process Intensification, Journal Year: 2024, Volume and Issue: unknown, P. 110094 - 110094
Published: Nov. 1, 2024
Language: Английский
Chem Catalysis, Journal Year: 2024, Volume and Issue: 4(7), P. 100933 - 100933
Published: Feb. 29, 2024
Language: Английский
Citations
6
Current Opinion in Green and Sustainable Chemistry, Journal Year: 2024, Volume and Issue: 47, P. 100923 - 100923
Published: April 10, 2024
Continuous flow processes have distinct advantages over batch chemistry when it comes to long-term sustainability in the chemical industry, and they are widely acknowledged as being a greener approach synthesis. However, despite this, high costs complexity of current commercial systems act barriers entry this key technology for new entrants, stymieing chemists transition continuous flow. In overview, we discuss how 3D printing has emerged transformative force seeking move into Alongside physical equipment microreactors, recent reports on incorporation catalysts 3D-printed reactors offers great promise recyclability environmental combined convergence catalysis represents shift towards environmentally conscious, efficient, standardized
Language: Английский
Citations
6
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 6, 2024
Abstract The development of sustainable chemistry underlying the quest to minimize and/or valorize waste in carbon‐neutral manufacture chemicals is followed over last four five decades. Both chemo‐ and biocatalysis have played an indispensable role this odyssey. particular developments protein engineering, metagenomics bioinformatics preceding three decades a crucial supporting facilitating widespread application both whole cell cell‐free biocatalysis. pressing need, driven by climate change mitigation, for drastic reduction greenhouse gas (GHG) emissions, has precipitated energy transition based on decarbonization defossilization organic production. latter involves biomass CO 2 as feedstock green electricity generated using solar, wind, hydroelectric or nuclear energy. use polysaccharides feedstocks will underpin renaissance carbohydrate with pentoses hexoses base bio‐based solvents polymers environmentally friendly downstream products. availability inexpensive solar led increasing attention electro(bio)catalysis photo(bio)catalysis which turn leading myriad innovations these fields.
Language: Английский
Citations
4
Molecular Catalysis, Journal Year: 2025, Volume and Issue: 573, P. 114814 - 114814
Published: Jan. 5, 2025
Language: Английский
Citations
0
Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Comptes Rendus Chimie, Journal Year: 2025, Volume and Issue: 28(G1), P. 151 - 170
Published: Feb. 21, 2025
Biocatalysis has gained attention in recent decades as a green and efficient method for producing high-value chemicals. Enzymes, notably due to their high selectivity, offer significant advantages organic synthesis. However, industrial implementation remains limited owing challenges such free enzyme instability, inhibition, difficulties catalyst recovery reuse. The coupling of biocatalysis with membrane technology enzyme-membrane reactors (EMRs) holds potential process intensification, it paves the way continuous-flow synthesis concatenated product purification biocatalyst recovery. By allowing flow hybrid processes (i.e., simultaneous biocatalytic reactions operations via one-pot methods), EMRs have increase reaction yields kinetics reduce downstream processing requirements. This review explores trends advancements production pharmaceutical building blocks fine We examine combination enzymes both polymeric ceramic membranes, highlighting respective benefits limitations. cover EMR where are used separately from devices employing membrane-immobilized enzymatic reactors. As immobilization in/on solid supports emerged an effective approach enhancing stability reusability, we argue that development is prime importance industry. These insights aim provide comprehensive overview role applications advancing within chemical industries. La biocatalyse suscite un intérêt marqué en tant que méthode plus verte et efficace pour la de molécules chimiques à haute valeur ajoutée. Les enzymes, grâce leur sélectivité élevée, offrent des avantages significatifs synthèse organique. Cependant, mise uvre industrielle reste limitée par défis tels l'instabilité libres, l'inhibition enzymatique, les difficultés liées récupération réutilisation ces biocatalyseurs. L'association avec technologie membranaire dans réacteurs membranaires enzymatiques (RME) représente une solution prometteuse ouvre voie lintensification procédés (ex : flux continu intégrée produits). En permettant hybrides continu, RME ont le potentiel daugmenter rendements cinétiques réactions tout réduisant besoins traitement aval. Cette revue explore tendances récentes avancées domaine produits ajoutée pharmaceutiques. Nous examinons combinaison denzymes membranes polymériques céramiques, mettant lumière leurs limites respectifs. couvrons utilisant soit libres séparées dispositifs membranaires, immobilisées surface membranes. Limmobilisation sur solides améliore stabilité réutilisabilité ; nous soutenons développement immobilisés est d'une capitale l'industrie pharmaceutique.
Citations
0
ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: 13(10), P. 3939 - 3950
Published: March 5, 2025
Oxygenases catalyze C-H oxyfunctionalization under mild reaction conditions and often display outstanding selectivity. However, their utilization is hampered by the difficulty of transporting oxygen across gas-liquid interface, which particularly problematic for continuous reactor systems can only be alleviated high pressure or use complex oxygen-permeable materials. Herein, directly released into medium phototrophic cyanobacterium Synechocystis sp. PCC 6803 expressing genes a Baeyer-Villiger Monooxygenase from Burkholderia xenovorans to drive oxidation cyclohexanone production polymer precursor, ε-caprolactone. The rates at photosynthetic solely were determined performing in coil with very limited external supply. In heterotrophic nonoxygen-producing Escherichia coli same gene, 10-fold lower specific activity was observed when performed compared batch mode underlining impact oxygen-limitation on volumetric productivity. contrast, cyanobacterial whole cells showed activities 16.7 13.5 U gDCW -1 nonoxygen-limited oxygen-limited flow, respectively. Net whole-cell biocatalyst during led steady-state concentration allowing productivities as 3 mmol L-1 h-1 highlighting advantages photoautotrophic oxygen-limiting conditions. Moreover, space-time yield improved 7-fold (2.8 vs 0.4 g h-1) utilizing mode. combination flow catalysis overcome current limitations photo(bio)oxidation achieve significant improvements terms productivity enabling more sustainable chemical synthesis. This approach using whole-cells cyanobacteria achieves notably ratio waste product (E-factor) higher atom economy mediated .
Language: Английский
Citations
0
ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: March 23, 2025
Heterocyclic amines are a key structural motif for the synthesis of pharmaceuticals (e.g., antibiotics) as well pesticides and flavors. In this regard, imine reductases (IREDs) have recently emerged highly selective sustainable alternative asymmetric reductive amination reactions. Herein, we applied six IREDs, two which were newly identified, in reduction heterocyclic imines with either N, S, or O substitution at C-4. Since IREDs NADPH-dependent enzymes, commercially available, supported glucose dehydrogenase was added cofactor-regenerating system. then immobilized on porous microparticles to further improve efficiency sustainability The strategic combination bioinformatic analysis immobilization screening resulted biocatalysts 95% retained activity. This enabled integration bienzymatic system into continuous-flow reactor leading >90% conversion 50 mM S-heterocyclic amine, 5-methyl-3,6-dihydro-2H-1,4-thiazine, residence time 30 min, reaching space-time yields up 14.3 g L–1 h–1. addition, (S)- (R)-stereoselectivity biocatalytic 1,4-disubstituted achieved by using identified fromGoodfellowiella coeruleoviolaceaandLabilithrix luteola, respectively.
Language: Английский
Citations
0
Comptes Rendus Chimie, Journal Year: 2025, Volume and Issue: 28(G1), P. 349 - 359
Published: April 7, 2025
Biocatalysis and flow chemistry are two complementary technologies that can be used to produce chemicals in a more efficient, sustainable, safe manner. Enzyme immobilization is key enabling their combination. Various methods, including carrier-free carrier-based techniques, offer distinct advantages terms of enzyme activity, stability, productivity. This review explores these strategies integration packed-bed reactors, highlighting industrial applications potential challenges.
Language: Английский
Citations
0
ChemCatChem, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract In this perspective article, we celebrate the accomplishments of female‐led research groups in biocatalysis. Through initiative, aim to showcase breadth and excellence women's increase their visibility within catalysis community. The authors wish emphasize that article represents only a small selection extraordinary women who have shaped field biocatalysis over time. Among them are scientists directly or significantly influenced inspired authors’ scientific journeys.
Language: Английский
Citations
0