Lipase Enzymes for Sustainable Synthesis of Pharmaceuticals and Chiral Organic Building Blocks

Advanced Sustainable Systems, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Abstract Biocatalysis is a green and sustainable process for synthesizing chiral organic building blocks active pharmaceutical ingredients (API). United Nations' Sustainable Development Goals 2030 advocates using green, sustainable, recyclable chemicals by industries to reduce environmental pollution. Pharmaceutical companies are adopting biocatalysis technologies manufacturing ingredients. The lipase‐catalyzed kinetic dynamic‐kinetic resolution method pharmaceutically accepted API. This review describes the reported methods API/KSM (Key Starting Material) molecules lipase enzymes over last ten years.

Language: Английский

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Towards Greener and More Cost-efficient Biosynthesis of Pharmaceuticals and Fragrance Molecules

CHIMIA International Journal for Chemistry, Journal Year: 2024, Volume and Issue: 78(4), P. 222 - 225

Published: April 24, 2024

Enzymes are natural catalysts which gaining momentum in chemical synthesis due to their exquisiteselectivity and biodegradability. However, the cost-efficiency sustainability of overall biocatalytic process must be enhanced unlock completely potential enzymes for industrial applications. To reach this goal, enzyme immobilization integration into continuous flow reactors have been cornerstone our research. We showed key examples advantages those tools biosynthesis antivirals, anticancer drugs, valuable fragrance molecules. By combining new strategies immobilize biocatalysts, innovative bioengineering approaches, development, performance reactions could boosted up 100-fold.

Language: Английский

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Stepping up: from lab scale to industrial processes

Chemical Engineering and Processing - Process Intensification, Journal Year: 2024, Volume and Issue: unknown, P. 110094 - 110094

Published: Nov. 1, 2024

Language: Английский

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