Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 8, 2025

Abstract Background Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development effective cost-effective targeted healthcare strategies. This study aimed to identify MLTCs associations with health-related quality life (HRQoL) in two UK population-based cohorts. Methods Age-stratified were identified at baseline Biobank ( n = 502,363, 54.6% female) UKHLS 49,186, 54.8% using latent class analysis (LCA). LCA was applied people who self-reported ≥ 2 LTCs (from 43 [UK Biobank], 13 [UKHLS]) baseline, across four age-strata: 18–36, 37–54, 55–73, 74 + years. Associations between MLTC HRQoL investigated tobit regression compared counts HRQoL. For HRQoL, we extracted EQ-5D index data from Biobank. In UKHLS, SF-12 mapped scores a standard preference-based algorithm. collected median 5 (UKHLS) 10 (UK Biobank) years follow-up. Analyses adjusted for available sociodemographic lifestyle covariates. Results 9 15 UKHLS. Clusters centred around pulmonary cardiometabolic common all age groups. Hypertension prominent ages, while depression featured younger groups painful conditions/arthritis middle-age onwards. showed different Biobank, high prevalence consistently largest deficits disease had lowest Notably, negative containing remained significant even after adjusting number LTCs. Conclusions While higher LTC remain important, have shown that cluster types an impact on Health service delivery planning future intervention design risk assessment should consider both better meet needs specific populations.

Language: Английский

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Building ADMISSION – A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital

Journal of Multimorbidity and Comorbidity, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 1, 2025

Background Multiple long-term conditions (MLTCs; commonly referred to as multimorbidity) are highly prevalent among people admitted hospital and therefore of critical importance hospital-based healthcare systems. To date, most research on MLTCs has been conducted in primary care or the general population with comparatively little work undertaken setting. Purpose describe rationale content ADMISSION: a four-year UK Research Innovation National Institute Health Care funded interdisciplinary programme that seeks, partnership public contributors, transform for living hospital. design Based across five academic centres, ADMISSION combines expertise clinical medicine, epidemiology, informatics, computing, biostatistics, social science, genetics pathway mapping examine patterns conditions, mechanisms, consequences pathways Data collection The uses routinely collected electronic health record data from large teaching hospitals, population-based cohort Biobank blood samples Scottish Register (SHARE). These approaches complemented by focused qualitative exploring perspectives professionals lived experience Conclusion will provide necessary foundations develop novel ways prevent treat their improve systems quality this underserved group.

Language: Английский

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Approaches to characterising multimorbidity in older people accessing hospital care: a scoping review

European Geriatric Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Abstract Purpose An increasing proportion of older adults accessing hospital care are living with multimorbidity, a high degree complexity multimorbidity in populations expected. We aimed to assess approaches taken characterise care, including how is considered. Methods Following established scoping review guidelines, all published studies that characterised population, average age ≥ 65 years, were identified via prespecified search strategy. Six electronic databases searched identify peer-reviewed literature September 2023 meeting eligibility criteria. Screening was undertaken by two independent reviewers, and data extracted using standard proforma. Results Of 5305 titles abstracts screened, 75 papers, reporting on 72 unique study across 24 countries, met inclusion There heterogeneity most aspects characterisation. Multimorbidity defined 43% ( n = 31/72) studies; 59/72, 82%) describe multimorbidity-outcome association. Number conditions considered ranged from 2 285 weighted indices used as measure 75% 54/72) studies, 56% 40/72) version the Charlson Comorbidity Index. Complexity explicitly studied 17% 12/72) studies. Discussion Our highlights characterisation limited consideration complexity. As who increases, better their multiple associated priority ensure delivery appropriately tailored care.

Language: Английский

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The interrelationship between multiple long-term conditions (MLTC) and delirium: a scoping review

Age and Ageing, Journal Year: 2024, Volume and Issue: 53(7)

Published: July 1, 2024

Delirium and multiple long-term conditions (MLTC) share numerous risk factors have been shown individually to be associated with adverse outcomes following hospitalisation. However, the extent which these common ageing syndromes studied together is unknown. This scoping review aims summarise our knowledge date on interrelationship between MLTC delirium.

Language: Английский

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