Investigation of the degree of family history of diabetes in different clusters of newly diagnosed type 2 diabetes in Thailand DOI Creative Commons
Watip Tangjittipokin, Tassanee Narkdontri, Nipaporn Teerawattanapong

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: May 8, 2025

Type 2 diabetes is a heterogeneous disease with strong genetic components. We showed earlier that newly diagnosed type in Thai patients could be categorized into four clusters. This study aimed to determine the evidence of hereditary factors these A total 487 subjects who were two years enrolled Siriraj Diabetes Center, Hospital Bangkok, Thailand. They divided clusters as previously described. The associations between patients' characteristics, degree family history (FHD), and tested using multinomial logistic regression. Among diabetes, there significant differences characteristics at baseline, including age diagnosis, BMI, waist circumference, blood sugar levels, vital signs, triglyceride, HDL, calculated LDL, creatinine eGFR (all p < .05). relatively young time diagnosis was associated having second-degree relatives (p .05) all when mild age-related (MARD) cluster no FHD control. Patients severe insulin-deficient (SIDD) had more first-degree (odds ratio = 1.85; .0354), while metabolic syndrome (MSD) 10.73; .001) obesity-related (MOD) group 6.66; .002), diabetes. Genetic might have various roles pathogenesis least patients. Our findings supported heterogeneity contributed clinical or different Further studies are needed larger sample size identify loci each cluster.

Language: Английский

Wellbeing medicine: exercise, metabolic syndrome, and more DOI Creative Commons
Constantine A. Stratakis

HORMONES, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

0
Causal Effects and Mediating Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease on Novel Subtypes of Adult-onset Diabetes: A Two-Step Mendelian Randomization Study DOI Creative Commons
Rongrong Li, Ting Wang, Hongping Luo

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103976 - 103976

Published: March 1, 2025

Language: Английский

Citations

0
Investigation of the degree of family history of diabetes in different clusters of newly diagnosed type 2 diabetes in Thailand DOI Creative Commons
Watip Tangjittipokin, Tassanee Narkdontri, Nipaporn Teerawattanapong

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: May 8, 2025

Type 2 diabetes is a heterogeneous disease with strong genetic components. We showed earlier that newly diagnosed type in Thai patients could be categorized into four clusters. This study aimed to determine the evidence of hereditary factors these A total 487 subjects who were two years enrolled Siriraj Diabetes Center, Hospital Bangkok, Thailand. They divided clusters as previously described. The associations between patients' characteristics, degree family history (FHD), and tested using multinomial logistic regression. Among diabetes, there significant differences characteristics at baseline, including age diagnosis, BMI, waist circumference, blood sugar levels, vital signs, triglyceride, HDL, calculated LDL, creatinine eGFR (all p < .05). relatively young time diagnosis was associated having second-degree relatives (p .05) all when mild age-related (MARD) cluster no FHD control. Patients severe insulin-deficient (SIDD) had more first-degree (odds ratio = 1.85; .0354), while metabolic syndrome (MSD) 10.73; .001) obesity-related (MOD) group 6.66; .002), diabetes. Genetic might have various roles pathogenesis least patients. Our findings supported heterogeneity contributed clinical or different Further studies are needed larger sample size identify loci each cluster.

Language: Английский

Citations

0