Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 22, 2025
With
the
rapid
development
of
nanotechnology,
layered
double
hydroxides
(LDHs)
have
attracted
considerable
attention
in
biomedical
field
due
to
their
highly
tunable
composition
and
structure,
superior
biocompatibility,
multifunctional
bioactivity,
exceptional
drug
delivery
performance.
However,
a
focused
comprehensive
review
addressing
role
LDHs
specifically
tissue
regeneration
has
been
lacking.
This
aims
fill
that
gap
by
providing
systematic
in-depth
overview
recent
advances
application
across
various
regenerative
domains,
including
bone
repair,
cartilage
reconstruction,
angiogenesis,
wound
healing,
nerve
regeneration.
Beyond
presenting
emerging
applications,
places
particular
emphasis
on
elucidating
underlying
mechanisms
through
which
exert
therapeutic
effects.
Although
demonstrate
promise
medicine,
clinical
translation
remains
its
infancy.
To
address
this,
we
not
only
provided
our
insights
into
personalized
problems
arise
tissues,
but
also
discussing
prospecting
common
challenges
LDHs.
These
include
optimizing
synthesis
techniques,
enhancing
biosafety
stability,
improving
drug-loading
efficiency,
designing
composite
materials,
establishing
pathways
facilitate
transition
from
laboratory
research
practice.
Emergent Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 27, 2024
Abstract
Wearable
and
flexible
materials
are
replacing
the
conventional
solid-state
sensors
in
diffident
biomedical
applications.
Hydrogel-based
sensing
elements
offer
several
appealing
inherent
properties
such
as
tissue
resembling
elasticity,
accessibility
for
modification
robust
mechanical
performance.
Their
widely
available
affordable
raw
components
in-addition
to
straightforward
synthesis
approach
make
hydrogels
material
wearable
This
work
demonstrates
development
of
new
sensitive
strain
using
polyvinyl
alcohol
(PVA)
κ-carrageenan
(κCA)
hydrogel
comprising
conductive
polyaniline
nanofibers
(PANI
NFs).
The
double-network
was
produced
via
chemical
crosslinking
PVA
with
Glutaraldehyde
(GA)
physical
κCA
potassium
ions
a
binary
solvent
system
deionized
water
glycerol.
PANI
NFs
were
then
embedded
interfacial
polymerization
(IP)
method
significantly
enhance
sensitivity
pristine
hydrogel.
obtained
has
been
involved
rigorous
characterization
capability
evaluation.
demonstrated
high-water
content
(86.6%),
high
swelling
percentage
acidic
solutions,
compressibility
up
60%
at
400
kPa,
electrical
conductivity
2.11
S/m,
thermal
stability
ranging
from
−
26.9
120
o
C.
resulted
linear
response
its
performance
applied
stress
(R
2
=
0.99).
Also,
developed
composite
1.5
mV/kPa
range
zero
170
kPa
recovery
times
~
300
ms
500
ms,
respectively.