Electroactive calcium-alginate/polycaprolactone/reduced graphene oxide nanohybrid hydrogels for skeletal muscle tissue engineering DOI Creative Commons
José Luis Aparicio-Collado, Natalia García-San-Martín, José Molina‐Mateo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 214, P. 112455 - 112455

Published: March 11, 2022

Graphene derivatives such as reduced graphene oxide (rGO) are used components of novel biomaterials for their unique electrical properties. Electrical conductivity is a crucial factor muscle cells, which electrically active. This study reports the development new type semi-interpenetrated polymer network based on two biodegradable FDA-approved biomaterials, sodium alginate (SA) and polycaprolactone (PCL), with Ca2+ ions SA crosslinker. Several drawbacks low cell adhesion weak structural stability can be improved incorporation PCL. Furthermore, this demonstrates how semi-IPN engineered rGO nanosheets (0.5% 2% wt/wt nanosheets) to produce electroactive nanohybrid composite biomaterials. The focuses microstructure enhancement physical biological properties these advanced materials, including water sorption, surface wettability, thermal behavior degradation, mechanical properties, conductivity, myogenic differentiation. results suggest formation complex nano-network different interactions between components: bonds chains induced by (egg-box model), links well themselves through ions, strong hydrogen bonding chains. significantly increases hydrogels, values in range tissue. In vitro cultures C2C12 murine myoblasts revealed that conductive hydrogels not cytotoxic greatly enhance myoblast These indicate have great potential biomedical applications related regeneration tissues, particularly skeletal tissue engineering.

Language: Английский

Functional role of crosslinking in alginate scaffold for drug delivery and tissue engineering: A review DOI

Lisette Aguero,

Saadet Alpdağtaş, Elif Ilhan

et al.

European Polymer Journal, Journal Year: 2021, Volume and Issue: 160, P. 110807 - 110807

Published: Sept. 29, 2021

Language: Английский

Citations

75

Poly (vinyl alcohol)-alginate as potential matrix for various applications: A focused review DOI
Anuj Kumar, Ankur Sood, Sung Soo Han

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 277, P. 118881 - 118881

Published: Nov. 11, 2021

Language: Английский

Citations

70

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives DOI Open Access
Anna Paradowska-Stolarz, Mieszko Więckiewicz, Artur Owczarek

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10337 - 10337

Published: Sept. 25, 2021

The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all materials, polymers are a very important class with wide spectrum applications. This review aims to provide state-of-the-art overview recent advances in field natural maintain or restore oral health. It focuses properties most common proteins polysaccharides origin terms meeting specific biological requirements increasingly demanding dentistry. use naturally derived different specialties for preventive therapeutic purposes has been discussed. major fields application cover caries management periodontal diseases, fabrication membranes scaffolds regeneration structures, manufacturing appliances dentures as well providing systems drug delivery. paper also includes comparative characteristic synthetic polymers. Finally, current highlights new perspectives, possible future advancements, challenges that may be encountered by researchers applications origin.

Language: Английский

Citations

68

Polysaccharide-Based Nanomedicines Targeting Lung Cancer DOI Creative Commons
Asif Ahmad Bhat, Gaurav Gupta, Khalid Saad Alharbi

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2788 - 2788

Published: Dec. 13, 2022

A primary illness that accounts for a significant portion of fatalities worldwide is cancer. Among the main malignancies, lung cancer recognised as most chronic kind around globe. Radiation treatment, surgery, and chemotherapy are some medical procedures used in traditional care However, these methods lack selectivity damage nearby healthy cells. Several polysaccharide-based nanomaterials have been created to transport chemotherapeutics reduce harmful adverse side effects improve response during anti-tumour reactions. To address drawbacks, class naturally occurring polymers called polysaccharides special physical, chemical, biological characteristics. They can interact with immune system induce better immunological response. Furthermore, because flexibility their structures, it possible create multifunctional nanocomposites excellent stability bioavailability delivery medicines tumour tissues. This study seeks present new views on use highlight current developments nanomedicines

Language: Английский

Citations

66

Electroactive calcium-alginate/polycaprolactone/reduced graphene oxide nanohybrid hydrogels for skeletal muscle tissue engineering DOI Creative Commons
José Luis Aparicio-Collado, Natalia García-San-Martín, José Molina‐Mateo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 214, P. 112455 - 112455

Published: March 11, 2022

Graphene derivatives such as reduced graphene oxide (rGO) are used components of novel biomaterials for their unique electrical properties. Electrical conductivity is a crucial factor muscle cells, which electrically active. This study reports the development new type semi-interpenetrated polymer network based on two biodegradable FDA-approved biomaterials, sodium alginate (SA) and polycaprolactone (PCL), with Ca2+ ions SA crosslinker. Several drawbacks low cell adhesion weak structural stability can be improved incorporation PCL. Furthermore, this demonstrates how semi-IPN engineered rGO nanosheets (0.5% 2% wt/wt nanosheets) to produce electroactive nanohybrid composite biomaterials. The focuses microstructure enhancement physical biological properties these advanced materials, including water sorption, surface wettability, thermal behavior degradation, mechanical properties, conductivity, myogenic differentiation. results suggest formation complex nano-network different interactions between components: bonds chains induced by (egg-box model), links well themselves through ions, strong hydrogen bonding chains. significantly increases hydrogels, values in range tissue. In vitro cultures C2C12 murine myoblasts revealed that conductive hydrogels not cytotoxic greatly enhance myoblast These indicate have great potential biomedical applications related regeneration tissues, particularly skeletal tissue engineering.

Language: Английский

Citations

62