Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions DOI Creative Commons
Sandip Patil, Xiaowen Chen, Feiqiu Wen

et al.

Cellular Microbiology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Pseudomonas aeruginosa , an antibiotic‐resistant opportunistic pathogen, poses significant challenges in treating infections, particularly immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, small‐molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR‐Cas systems, nanotechnology, show promise preclinical studies. Despite advancements, persist, prompting need for a multifaceted approach targeting various aspects of P. pathogenesis effective infection management. provides comprehensive perspective on status directions against aeruginosa.

Language: Английский

Sustainable Synthesis of Au-ZnO Nanocomposites for Effective Photocatalytic Degradation of Methylene Blue in Wastewater and Therapeutic Applications DOI
Arunagiri Sharmila, Chinnadurai Immanuel Selvaraj

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0

Phytofabrication of biocompatible zinc oxide nanoparticle using Gymnema sylvestre and its potent in vitro antibacterial, antibiofilm, and cytotoxicity against human breast cancer cells (MDA-MB-231) DOI

R. Kavipriya,

Ramasamy Ramasubburayan

Bioprocess and Biosystems Engineering, Journal Year: 2024, Volume and Issue: 47(8), P. 1377 - 1391

Published: May 31, 2024

Language: Английский

Citations

3

ZnO nanoparticles: A sustainable fabrication enhanced by eggshell waste and its germicidal, anti‐proliferative, and photodecomposition properties DOI
S. Vijayakumar,

Sathish Pandidurai,

Mohammad Ahmad Wadaan

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(3)

Published: March 1, 2024

Abstract Recently, there has been a lot of interest in the fabrication metal oxide nanoparticles (NPs) due to growing importance developing recyclable assets, affordable methods, sustainable substances, and safe compounds. The current study demonstrates environmentally friendly ZnO NPs through use an aqueous extract derived from discarded eggshells. analysis involved UV, x‐ray diffraction (XRD), Fourier‐transform infrared spectroscopy (FT‐IR), field‐emission scanning electron microscopy (FE‐SEM) with EDX techniques. anti‐germs effects fabricated on pathogens were investigated using agar diffusion technique. cell‐damaging assessed MTT assay, whereas photodecomposition capacity was examined Congo red methylene blue dye. X‐ray revealed existence tetragonal crystal morphology. generated have crystallite size 17.6 nm. According FE‐SEM examination, created sample's average grain determined be between 20 30 production showed remarkable properties against human pathogenic organisms had good efficacy damaging Osteosarcoma cell lines (MG‐63) during experiment. Additionally, it emerged that manifestation catalytic efficiency fell by 78.1% after 60 min for blue. Based findings, shows great potential across multiple fields such as anti‐germs, anti‐proliferative, properties.

Language: Английский

Citations

2

Investigations on Chemically Synthesized Pure and Doped Manganese Dioxide Nanoparticles for Dye Removal and Photocatalytic Applications DOI

Lingeswari Chellappan,

Balu Thangaraj,

Nagarajan Muthukurumban

et al.

Journal of Fluorescence, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 24, 2024

Language: Английский

Citations

1

ANTI-ASPERGILLUS NIGER ACTION OF BIOSYNTHESIZED SILICON DIOXIDE NANOPARTICLES ALONE OR COMBINED WITH MATRICARIA CHAMOMILLA L. EXTRACT DOI Open Access
Zakaria Baka,

Asmaa M. El-Sharkawy,

Mohamed M. El‐Zahed

et al.

Journal of Microbiology Biotechnology and Food Sciences, Journal Year: 2024, Volume and Issue: 13(5), P. e10816 - e10816

Published: Feb. 28, 2024

Fungi are the most frequent microorganisms that cause seed damage throughout development, wreaking much more post- and pre-infections significantly reducing quality. Conventional antifungal agents have failed to overcome a variety of Aspergillus spp. These strains been associated with development high-potency mycotoxins, which mould infections in fruits vegetables as well harmful health effects. Different species, such Aspergillus, Penicillium, Alternaria, Fusarium were isolated from imported yellow corn samples; however, was prevalent fungus. The current work attempts synthesize novel, effective nanomaterials stable by employing efficient approaches. An extract Matricaria chamomilla L. used biosynthesis silicon dioxide nanoparticles (SiO2 NPs) at room temperature. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), Zeta analyses characterize biosynthesized NPs. average size SiO2 NPs found be 17-28 nm. TEM images confirm biogenesis spherical-shaped, well-dispersed zeta potential graph shows negative value (-31.0 mV). activity M. extract, NPs, combined investigated against A. niger isolate compared miconazole. revealed higher than miconazole inhibition zones 25±0.54, 17±0.37, 20±0.61 13±0.23 mm, respectively. This provides good alternate technique is an agent, supplemented niger, pathogen for humans crop plants.

Language: Английский

Citations

1

Elucidating study of “Eri” and Cannabis sativa: An antibacterial approach via B/nZVCu-M NPs fabrication DOI
Dipanwita Basak, R. Kashyap, Debasis Borah

et al.

Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 52, P. 104865 - 104865

Published: Aug. 4, 2024

Language: Английский

Citations

1

Synergistic effect of zinc oxide-cinnamic acid nanoparticles for wound healing management: in vitro and zebrafish model studies DOI Creative Commons
Jehad Zuhair Tayyeb, Ajay Guru,

Karthikeyan Kandaswamy

et al.

BMC Biotechnology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 10, 2024

Wound infections resulting from pathogen infiltration pose a significant challenge in healthcare settings and everyday life. When the skin barrier is compromised due to injuries, surgeries, or chronic conditions, pathogens such as bacteria, fungi, viruses can enter body, leading infections. These range mild severe, causing discomfort, delayed healing, and, some cases, life-threatening complications. Zinc oxide (ZnO) nanoparticles (NPs) have been widely recognized for their antimicrobial wound healing properties, while cinnamic acid known its antioxidant anti-inflammatory activities. Based on these combination of ZnO NPs with (CA) was hypothesized enhanced efficacy addressing promoting healing. This study aimed synthesize evaluate potential ZnO-CN multifunctional agent treatment. were synthesized characterized using key techniques confirm structure composition. The evaluated through standard vitro assays, demonstrating strong free radical scavenging inhibition protein denaturation. activity tested against common pathogens, revealing effective at minimal concentration. A zebrafish model employed assess both safety therapeutic nanoparticles, showing no toxicity concentrations facilitating faster closure. Additionally, pro-inflammatory cytokine gene expression analyzed understand role mechanisms. In conclusion, demonstrate potent antioxidant, anti-inflammatory, making them promising candidates Given properties non-toxicity concentrations, hold clinical management, warranting further investigation human models.

Language: Английский

Citations

1

Bio-templated Synthesis of Multi-functional Bimetallic Ag-Cu Nanospheres: Unveiling Therapeutic Potential DOI

Monika Kataria,

Sant Lal, Neeraj Dilbaghi

et al.

Nano LIFE, Journal Year: 2024, Volume and Issue: 15(01)

Published: May 31, 2024

Antimicrobial medicines serve as the bedrock of modern medical practices. Increasing multidrug resistance compromises surgical processes and increases healthcare costs. Therefore, a combinational approach has become pre-requisite for sustainable care. In recent decade, biologically synthesized metallic nanoparticles have emerged class potent antimicrobials. this study, green bimetallic silver–copper oxide (Ag–Cu) nanospheres been prepared using culture supernatant Bacillus subtilis (MTCC 441) bacteria to effectively target infectious microbes. The hydrodynamic diameter depicted by dynamic light scattering (DLS) was 143.5 nm, while polydispersity index (PI) 0.367 zeta potential −25.2 mV indicated toward uniform size distribution excellent colloidal stability. Ag–Cu 22.24 ± 8.01 nm were B. MTCC 441. High-end techniques such transmission electron microscopy (TEM), scanning (SEM), X-ray diffraction (XRD) Fourier transform infrared (FTIR) spectroscopy revealed (22.24 nm), spherical morphology, crystal structure surface functionalization nanospheres, respectively. antimicrobial assessed against multidrug-resistant (MDR) bacterial strains anti-free radical capacity evaluated through 2,2-Diphenyl-1-picrylhydrazyl (DPPH) [Formula: see text] free inhibition. anti-inflammatory study also performed investigate biomedical nanosphere. comprehensive analysis antimicrobial, anti-oxidative assays presents spheres suitable candidates be used in various applications.

Language: Английский

Citations

0

Synthesis, structural analysis and photocatalytic ability of novel Mg-Al-Ag and Mg-Al-Ag-Zn hydrotalcite-like compounds DOI
Quang Tung Nguyen,

Dinh Hieu Vu,

Tra My Duong

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 41, P. 110239 - 110239

Published: Aug. 28, 2024

Language: Английский

Citations

0

Impact of ZnO nanoparticles on MagA gene expression in Klebsiella pneumoniae isolated from diabetic foot ulcers DOI Open Access

Mustafa Muhammed Jadooa,

Haider Turky Mousa Al-Mousawi,

Nadhim Mushtaq Hashim Al-bderee

et al.

Asia-Pacific Journal of Molecular Biology and Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 248 - 256

Published: Sept. 26, 2024

Diabetes mellitus (DM) is an accumulation of glucose in the blood. Diabetic divided into gestational diabetes, type 1 and 2. Complications diabetes include diabetic foot ulcers. The most important complication ulcers bacterial infection, which leads to gangrene when various types antibiotics fail prevent infections. To explore effect synthetic zinc oxide nanoparticles (ZnONPs) on expression MagA gene Klebsiella pneumoniae isolated from ulcer cases. ZnONPs were biosynthesized by Aspergillus niger characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD), UV-visible spectroscopy. inhibitory K. isolates was examined determining minimum concentration (MIC) ZnONPs. Besides, values before after exposure would be RT-qPCR, with 16SrRNA as reference gene. According SEM XRD results, are form nanocrystals have small spherical crystals average size 13.5 nm. highest optical density synthesized obtained at 390 exhibit a strong inhibition zone against corresponding 125 μg/mL. fold ranged 0.042 0.118. research reveals that antibacterial potential affect strains. results present study indicate can indeed used treatment infectious bacteria.

Language: Английский

Citations

0