Cellular Microbiology,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Pseudomonas
aeruginosa
,
an
antibiotic‐resistant
opportunistic
pathogen,
poses
significant
challenges
in
treating
infections,
particularly
immunocompromised
individuals.
This
review
explores
current
and
future
innovative
approaches
to
suppress
its
growth
virulence.
We
delve
into
the
bacterium’s
virulence
factors,
discussing
existing
strategies
like
antibiotics,
bacteriophages,
probiotics,
small‐molecule
inhibitors.
Additionally,
novel
approaches,
including
RNA
interference,
CRISPR‐Cas
systems,
nanotechnology,
show
promise
preclinical
studies.
Despite
advancements,
persist,
prompting
need
for
a
multifaceted
approach
targeting
various
aspects
of
P.
pathogenesis
effective
infection
management.
provides
comprehensive
perspective
on
status
directions
against
aeruginosa.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(3)
Published: March 1, 2024
Abstract
Recently,
there
has
been
a
lot
of
interest
in
the
fabrication
metal
oxide
nanoparticles
(NPs)
due
to
growing
importance
developing
recyclable
assets,
affordable
methods,
sustainable
substances,
and
safe
compounds.
The
current
study
demonstrates
environmentally
friendly
ZnO
NPs
through
use
an
aqueous
extract
derived
from
discarded
eggshells.
analysis
involved
UV,
x‐ray
diffraction
(XRD),
Fourier‐transform
infrared
spectroscopy
(FT‐IR),
field‐emission
scanning
electron
microscopy
(FE‐SEM)
with
EDX
techniques.
anti‐germs
effects
fabricated
on
pathogens
were
investigated
using
agar
diffusion
technique.
cell‐damaging
assessed
MTT
assay,
whereas
photodecomposition
capacity
was
examined
Congo
red
methylene
blue
dye.
X‐ray
revealed
existence
tetragonal
crystal
morphology.
generated
have
crystallite
size
17.6
nm.
According
FE‐SEM
examination,
created
sample's
average
grain
determined
be
between
20
30
production
showed
remarkable
properties
against
human
pathogenic
organisms
had
good
efficacy
damaging
Osteosarcoma
cell
lines
(MG‐63)
during
experiment.
Additionally,
it
emerged
that
manifestation
catalytic
efficiency
fell
by
78.1%
after
60
min
for
blue.
Based
findings,
shows
great
potential
across
multiple
fields
such
as
anti‐germs,
anti‐proliferative,
properties.
Journal of Microbiology Biotechnology and Food Sciences,
Journal Year:
2024,
Volume and Issue:
13(5), P. e10816 - e10816
Published: Feb. 28, 2024
Fungi
are
the
most
frequent
microorganisms
that
cause
seed
damage
throughout
development,
wreaking
much
more
post-
and
pre-infections
significantly
reducing
quality.
Conventional
antifungal
agents
have
failed
to
overcome
a
variety
of
Aspergillus
spp.
These
strains
been
associated
with
development
high-potency
mycotoxins,
which
mould
infections
in
fruits
vegetables
as
well
harmful
health
effects.
Different
species,
such
Aspergillus,
Penicillium,
Alternaria,
Fusarium
were
isolated
from
imported
yellow
corn
samples;
however,
was
prevalent
fungus.
The
current
work
attempts
synthesize
novel,
effective
nanomaterials
stable
by
employing
efficient
approaches.
An
extract
Matricaria
chamomilla
L.
used
biosynthesis
silicon
dioxide
nanoparticles
(SiO2
NPs)
at
room
temperature.
Ultraviolet-visible
spectroscopy
(UV-Vis),
Fourier
transform
infrared
(FT-IR),
X-ray
diffraction
(XRD),
transmission
electron
microscopy
(TEM),
Zeta
analyses
characterize
biosynthesized
NPs.
average
size
SiO2
NPs
found
be
17-28
nm.
TEM
images
confirm
biogenesis
spherical-shaped,
well-dispersed
zeta
potential
graph
shows
negative
value
(-31.0
mV).
activity
M.
extract,
NPs,
combined
investigated
against
A.
niger
isolate
compared
miconazole.
revealed
higher
than
miconazole
inhibition
zones
25±0.54,
17±0.37,
20±0.61
13±0.23
mm,
respectively.
This
provides
good
alternate
technique
is
an
agent,
supplemented
niger,
pathogen
for
humans
crop
plants.
BMC Biotechnology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 10, 2024
Wound
infections
resulting
from
pathogen
infiltration
pose
a
significant
challenge
in
healthcare
settings
and
everyday
life.
When
the
skin
barrier
is
compromised
due
to
injuries,
surgeries,
or
chronic
conditions,
pathogens
such
as
bacteria,
fungi,
viruses
can
enter
body,
leading
infections.
These
range
mild
severe,
causing
discomfort,
delayed
healing,
and,
some
cases,
life-threatening
complications.
Zinc
oxide
(ZnO)
nanoparticles
(NPs)
have
been
widely
recognized
for
their
antimicrobial
wound
healing
properties,
while
cinnamic
acid
known
its
antioxidant
anti-inflammatory
activities.
Based
on
these
combination
of
ZnO
NPs
with
(CA)
was
hypothesized
enhanced
efficacy
addressing
promoting
healing.
This
study
aimed
synthesize
evaluate
potential
ZnO-CN
multifunctional
agent
treatment.
were
synthesized
characterized
using
key
techniques
confirm
structure
composition.
The
evaluated
through
standard
vitro
assays,
demonstrating
strong
free
radical
scavenging
inhibition
protein
denaturation.
activity
tested
against
common
pathogens,
revealing
effective
at
minimal
concentration.
A
zebrafish
model
employed
assess
both
safety
therapeutic
nanoparticles,
showing
no
toxicity
concentrations
facilitating
faster
closure.
Additionally,
pro-inflammatory
cytokine
gene
expression
analyzed
understand
role
mechanisms.
In
conclusion,
demonstrate
potent
antioxidant,
anti-inflammatory,
making
them
promising
candidates
Given
properties
non-toxicity
concentrations,
hold
clinical
management,
warranting
further
investigation
human
models.
Nano LIFE,
Journal Year:
2024,
Volume and Issue:
15(01)
Published: May 31, 2024
Antimicrobial
medicines
serve
as
the
bedrock
of
modern
medical
practices.
Increasing
multidrug
resistance
compromises
surgical
processes
and
increases
healthcare
costs.
Therefore,
a
combinational
approach
has
become
pre-requisite
for
sustainable
care.
In
recent
decade,
biologically
synthesized
metallic
nanoparticles
have
emerged
class
potent
antimicrobials.
this
study,
green
bimetallic
silver–copper
oxide
(Ag–Cu)
nanospheres
been
prepared
using
culture
supernatant
Bacillus
subtilis
(MTCC
441)
bacteria
to
effectively
target
infectious
microbes.
The
hydrodynamic
diameter
depicted
by
dynamic
light
scattering
(DLS)
was
143.5
nm,
while
polydispersity
index
(PI)
0.367
zeta
potential
−25.2
mV
indicated
toward
uniform
size
distribution
excellent
colloidal
stability.
Ag–Cu
22.24
±
8.01
nm
were
B.
MTCC
441.
High-end
techniques
such
transmission
electron
microscopy
(TEM),
scanning
(SEM),
X-ray
diffraction
(XRD)
Fourier
transform
infrared
(FTIR)
spectroscopy
revealed
(22.24
nm),
spherical
morphology,
crystal
structure
surface
functionalization
nanospheres,
respectively.
antimicrobial
assessed
against
multidrug-resistant
(MDR)
bacterial
strains
anti-free
radical
capacity
evaluated
through
2,2-Diphenyl-1-picrylhydrazyl
(DPPH)
[Formula:
see
text]
free
inhibition.
anti-inflammatory
study
also
performed
investigate
biomedical
nanosphere.
comprehensive
analysis
antimicrobial,
anti-oxidative
assays
presents
spheres
suitable
candidates
be
used
in
various
applications.
Asia-Pacific Journal of Molecular Biology and Biotechnology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 248 - 256
Published: Sept. 26, 2024
Diabetes
mellitus
(DM)
is
an
accumulation
of
glucose
in
the
blood.
Diabetic
divided
into
gestational
diabetes,
type
1
and
2.
Complications
diabetes
include
diabetic
foot
ulcers.
The
most
important
complication
ulcers
bacterial
infection,
which
leads
to
gangrene
when
various
types
antibiotics
fail
prevent
infections.
To
explore
effect
synthetic
zinc
oxide
nanoparticles
(ZnONPs)
on
expression
MagA
gene
Klebsiella
pneumoniae
isolated
from
ulcer
cases.
ZnONPs
were
biosynthesized
by
Aspergillus
niger
characterized
using
scanning
electron
microscopy
(SEM),
Fourier
transform
infrared
(FTIR),
X-ray
diffraction
(XRD),
UV-visible
spectroscopy.
inhibitory
K.
isolates
was
examined
determining
minimum
concentration
(MIC)
ZnONPs.
Besides,
values
before
after
exposure
would
be
RT-qPCR,
with
16SrRNA
as
reference
gene.
According
SEM
XRD
results,
are
form
nanocrystals
have
small
spherical
crystals
average
size
13.5
nm.
highest
optical
density
synthesized
obtained
at
390
exhibit
a
strong
inhibition
zone
against
corresponding
125
μg/mL.
fold
ranged
0.042
0.118.
research
reveals
that
antibacterial
potential
affect
strains.
results
present
study
indicate
can
indeed
used
treatment
infectious
bacteria.