Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions DOI Creative Commons
Sandip Patil, Xiaowen Chen, Feiqiu Wen

et al.

Cellular Microbiology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Pseudomonas aeruginosa , an antibiotic‐resistant opportunistic pathogen, poses significant challenges in treating infections, particularly immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, small‐molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR‐Cas systems, nanotechnology, show promise preclinical studies. Despite advancements, persist, prompting need for a multifaceted approach targeting various aspects of P. pathogenesis effective infection management. provides comprehensive perspective on status directions against aeruginosa.

Language: Английский

Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review DOI Creative Commons
Anaís Bezerra de Gusmão, Priscilla Barbosa Sales de Albuquerque, Ana Carolina de Carvalho Correia

et al.

Applied Nano, Journal Year: 2024, Volume and Issue: 5(4), P. 205 - 226

Published: Oct. 10, 2024

Wound healing is rarely seen as a problem in healthy individuals; however, under certain pathophysiological conditions, this process can be impaired, leading to the emergence of chronic wounds, which are themselves serious public health problem. This work aimed review most important recent literature on use nanoparticles Ag, Au, and Zn produced from plant extracts their application agents. To that end, we provide an insight into pathophysiology wound main routes obtaining metallic nanoparticles. The methodology synthesis, part so-called green has been focus several studies medicinal plants substrate produce silver, gold, zinc Their agents closely related natural antimicrobial, anti-inflammatory, cicatrizing properties. Finally, address vitro vivo efficiency (MNPs) synthesized applied different pharmaceutical forms. For instance, excellent contraction rates obtained silver gold NPs, respectively, were Euphorbia milii (92%) Plectranthus aliciae (almost 97%) analyses. Based satisfactory results, find MNPs potential therapeutic alternative compared traditional synthetic foresee production new drugs.

Language: Английский

Citations

0

Antimicrobial activity and nanoremediation of heavy metals using biosynthesized CS/GO/ZnO nanocomposite by Bacillus subtilis ATCC 6633 alone or immobilized in a macroporous cryogel DOI Creative Commons
Mohamed M. El‐Zahed, Mohamed Abou-Dobara,

Marwa M. El-Khodary

et al.

Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 15, 2024

The world society is still suffering greatly from waterborne infections, with developing countries bearing most of the morbidity and death burden, especially concerning young children. Moreover, microbial resistance one prevalent global problems that extends need for self-medication healing period, or it may be linked to treatment failure results in further hospitalization, higher healthcare expenses, mortality rates. Thus, innovative synthesis new antimicrobial materials required preserve environment enhance human health.

Language: Английский

Citations

0

Advancing sustainable agriculture: Metal-doped urea–hydroxyapatite hybrid nanofertilizer for agro-industry DOI Creative Commons

Zohaib Waheed,

Aneela Anwar, Ayesha Sadiqa

et al.

Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Nanotechnology holds excessive potential for addressing agricultural challenges such as soil deprivation, nutrient deficiencies, low harvests, and leaching. Nanofertilizers enable more efficient absorption by plants due to their enlarged surface area, bestowing viable solutions. Urea–hydroxyapatite hybrid (urea–HA hybrid) was successfully synthesized via a coprecipitation approach doping nanohydroxyapatite with copper zinc along urea. The nanohybrids were analyzed applying various techniques Fourier transform infrared spectroscopy, energy-dispersive spectroscopy (EDS), scanning electron microscopy, X-ray powder diffraction (XRD). evidence the crystalline structure of HA confirmed peaks present in XRD analysis at 25.89°, 28.77°, 32.11°, while urea validated 39.29°. nanosized hexagonal nanorods approximately 16 ± 1.5 nm, incorporation urea, Cu, Zn. components urea–HA (Ca, P, C, O, N) EDS traces Si. Antibacterial antifungal activities investigated against phytopathogenic microbes. nanohybrid significantly inhibits growth Clavibacter michiganensis , Xanthomonas campestris Macrophomina phaseolina Sclerotium rolfsii . A fertilization trial using on Citrus limon has demonstrated 30 cm within 8 weeks treatment, accompanied brighter-colored leaves. Thus, enabled slow release nutrients, which had significant impact plant will also effectively manage disease control phytopathogens. this innovative addresses regarding delivery effectively.

Language: Английский

Citations

0

Evaluation of titanium dioxide/catechol polyurethane composite for antimicrobial resistance and wastewater treatment DOI Creative Commons

Mona A. El-Harairey,

Hoda Saad, E.A. Moawed

et al.

Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)

Published: Nov. 1, 2024

In this study, a novel approach for the environmentally conscious extraction of titanium dioxide from ilmenite ore while limiting environmental impact and enhancing advantage an economic process. Leaching conditions were tested with different acids effective separation TiO2 optimized concerning experimental parameters. TiO2NPs characterized using tools. Catechol polyurethane foam immobilized was prepared its antimicrobial action against Gram-negative bacterium E. coli, Gram-positive B. cereus, fungus A. niger. CAT-PUF /TiO2NPs showed effect niger inhibition zones 27 ± 0.14, 12 22 0.06 mm, respectively. Incorporating bioinformatics, research contributes to burgeoning field nanotechnology-enabled materials, offering insights into potential applications CAT-PUF/TiO2NPs in combating microbial threats. Through bio-informatics tools, toxicity synthesized nanoparticles assessed, providing valuable their safety profile impact. Furthermore, simulating binding affinity between target biomolecules, such as cell membrane proteins or enzyme receptors, aspect sheds light on mechanistic underpinnings efficacy.

Language: Английский

Citations

0

Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions DOI Creative Commons
Sandip Patil, Xiaowen Chen, Feiqiu Wen

et al.

Cellular Microbiology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Pseudomonas aeruginosa , an antibiotic‐resistant opportunistic pathogen, poses significant challenges in treating infections, particularly immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, small‐molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR‐Cas systems, nanotechnology, show promise preclinical studies. Despite advancements, persist, prompting need for a multifaceted approach targeting various aspects of P. pathogenesis effective infection management. provides comprehensive perspective on status directions against aeruginosa.

Language: Английский

Citations

0