Nanoscale, Journal Year: 2024, Volume and Issue: 16(17), P. 8573 - 8582
Published: Jan. 1, 2024
Janus nanoparticles with soluble polyvinylpyrrolidone patches located on the insoluble Eudragit RL100 sides were prepared using a side-by-side electrospraying method and are demonstrated to provide biphasic release of paracetamol in turn faster action longer time periods blood drug concentration for therapy.
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124180 - 124180
Published: May 4, 2024
Language: Английский
Citations
38
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(2)
Published: March 1, 2024
Core-shell structure is a concentric circle found in nature. The rapid development of electrospinning technology provides more approaches for the production core-shell nanofibers. nanoscale effects and expansive specific surface area nanofibers can facilitate dissolution drugs. By employing ingenious structural designs judicious polymer selection, specialized nanofiber drug delivery systems be prepared to achieve controlled release. synergistic combination materials exhibits strong strategy enhancing utilization efficiency customizing release profile Consequently, multi-chamber hold great promise highly efficient disease treatment. However, little attention concentration focused on effect In this review, we introduced different fabrication techniques nanostructures, including advanced technologies functionalization. Subsequently, reviewed behaviors their potential needs comprehensive elucidation based electrospun nanostructures could inspire exploration novel systems. Furthermore, once these fibers with customizable profiles move toward industrial mass production, they will potentially promote pharmacy treatment various diseases. This article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies.
Language: Английский
Citations
37
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 5, 2024
Diabetic wounds are a significant subset of chronic characterized by elevated levels inflammatory cytokines, matrix metalloproteinases (MMPs), and reactive oxygen species (ROS). They also associated with impaired angiogenesis, persistent infection, high likelihood hospitalization, leading to substantial economic burden for patients. In severe cases, amputation or even mortality may occur. foot ulcers (DFUs) common complication diabetes, up 25% diabetic patients being at risk developing over their lifetime, more than 70% ultimately requiring amputation. Electrospun scaffolds exhibit structural similarity the extracellular (ECM), promoting adhesion, growth, migration fibroblasts, thereby facilitating formation new skin tissue wound site. The composition size electrospun can be easily adjusted, enabling controlled drug release through fiber structure modifications. porous nature these facilitates gas exchange absorption exudate. Furthermore, surface readily modified impart specific functionalities, making electrospinning nanofiber highly promising treatment wounds. This article provides concise overview healing process in normal pathological mechanisms underlying wounds, including complications such as ulcers. It explores advantages treatment. Additionally, it summarizes findings from various studies on use different types reviews methods loading onto scaffolds. These advancements broaden horizon effectively treating
Language: Английский
Citations
36
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 646 - 646
Published: April 8, 2024
Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded active ingredients for providing functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed polycaprolactone fenoprofen core working fluid, different types unspinnable fluids (including pure solvent, nanosuspension containing tranexamic acid hydroxyapatite, dilute polymeric comprising acid, polyvinylpyrrolidone) explored to implement processes creating multifunctional nanofibers. Their morphologies inner structures assessed through scanning transmission electron microscopes, which all showed a linear format without discerned beads or spindles diameter smaller than 1.0 μm, some them had incomplete core–shell nanostructures, represented by symbol @. Additionally, strange details about sheaths’ topographies observed, included cracks, adhesions, embedded nanoparticles. XRD FTIR verified that drugs presented amorphous state, resulted from fine compatibility among involved components. All samples demonstrated have hydrophilic property exhibited lower water contact angle 40° 300 ms. In vitro dissolution tests indicated was released sustained manner over 6 h typical Fickian diffusion mechanism. Hemostatic intentional distribution on shell sections able endow rapid hemostatic effect within 60 s.
Language: Английский
Citations
34
Nanoscale, Journal Year: 2024, Volume and Issue: 16(17), P. 8573 - 8582
Published: Jan. 1, 2024
Janus nanoparticles with soluble polyvinylpyrrolidone patches located on the insoluble Eudragit RL100 sides were prepared using a side-by-side electrospraying method and are demonstrated to provide biphasic release of paracetamol in turn faster action longer time periods blood drug concentration for therapy.
Language: Английский
Citations
28