Cited by Fabrication of hollow microneedles with double-layer shell structure for rapid and prolonged local anesthesia

Skin-adaptive Nanofiber-based Adhesive Electronics with Octopus-like 3D Suction cups for Enhanced Transdermal Delivery DOI

Minwoo Song,

Hyoung-Ki Park,

Minjin Kim

et al.

Published: April 3, 2025

Abstract Transdermal drug delivery (TDD) systems have evolved, with skin electronics emerging as an advanced technology capable of enabling controlled and efficient administration. However, conventional often rely on rigid materials expensive fabrication processes, limiting flexibility, adhesion, long-term usability. To overcome these challenges, nanofiber-based adhesive gained attention a promising alternative, offering high large surface area for loading, release mechanisms. In this study, we developed cellulose nanofiber (CNFs)-based by integrating three-dimensional (3D) octopus-inspired architecture (OIA) conductive layer. The OIA imprinted CNFs enhanced adhesion leveraging the synergistic effect its structure ability to remain stable even after absorbing high-viscosity active ingredient solutions. Unlike fiber-based TDD flatforms, which lose structural integrity upon liquid absorption, optimized CNFs-OIA retains architecture, suction-based improve attachment. further enhance transdermal efficiency, integrated layer carbon nanotubes (CNTs) into CNFs-OIA. This interface generates microcurrents that reduce electrical resistance stratum corneum facilitate ionization ingredients, thereby improving penetration. These findings suggest optimization material integration, combined microcurrent-assisted delivery, can extend applications beyond cosmetics, potential implications pharmaceutical delivery.

Language: Английский

Citations

Recent advances in cutaneous drug delivery by iontophoresis DOI

Idejan P. Gross, Ana Luiza Lima, Lívia Cristina Lira de Sá Barreto

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Iontophoresis has been extensively studied for topical and transdermal drug delivery to stimulate the absorption of molecules that would hardly pass through outermost layer skin passively. Recent research focused on its combination with nanoparticle-based systems or microneedles expand therapeutic applications. This review explores fundamental principles iontophoresis, focusing key factors influencing transport mechanisms, provides a discussion field's current state. A comprehensive analysis articles published available online in 2024 was conducted, categorizing studies by their application areas, systems, iontophoretic conditions, experimental limitations. The findings reveal recent focus wound healing repair, advancements treating inflammation, pain, cancer. Market translation requires standardized protocols, particularly parameters preclinical models, along development cost-effective commercial devices. Additionally, while cutaneous have increasingly benefited from machine learning approaches, iontophoresis remains underexplored. With growing interest associating Internet Things, such an integration, if combined AI tools, could offer promising opportunities personalized, real-time treatments modern dermatology, systems.

Language: Английский

Citations

Systemic Risks of Topical Anesthetics in Barrier-Compromised Dermatologic Patients DOI