Human Immunology, Journal Year: 2024, Volume and Issue: 86(1), P. 111220 - 111220
Published: Dec. 19, 2024
Language: Английский
Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 26 - 26
Published: Feb. 2, 2025
Infertility affects 8–12% of couples worldwide, and 30–75% preclinical pregnancy losses are due to a failure during the implantation process. Exposure endocrine disruptors, like bisphenols, among others, has been associated with increase in infertility observed past decades. An correlated exposure disruptors bisphenols. The uterus harbors its own microbiota, changes this microbiota have linked several gynecological conditions, including reproductive failure. There no studies on effects bisphenols uterine–microbiota composition, but some inferences can be gleaned by looking at gut. Bisphenols alter gut molecular mechanism which regulates intestinal permeability involves Toll-like receptors (TLRs) tight junction (TJ) proteins. TJs participate embryo uterus, bisphenol disrupts expression localization TJ aim review is summarize current knowledge female tract (FRT), association different diseases—particularly failure—the composition health, mechanisms regulating interactions crucial for implantation. This also highlights existing gaps outlines research needs future risk assessments regarding reproduction.
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
This review explores the correlation between endometrial microbes and infertility, focusing on impact of microbiota fertility outcomes. The healthy status uterine microorganisms, predominantly Lactobacillus, plays a crucial role in reproductive health. Studies have shown that composition changes with hormonal fluctuations during menstrual cycle, affecting receptivity embryo implantation. presence specific bacteria, such as Lactobacillus species, has been associated successful pregnancy outcomes, while dysbiosis linked to implantation failure infertility. Factors like age, changes, immune responses influence microbes, impacting fertility. Chronic endometritis, characterized by inflammation endometrium, recurrent Understanding complex interactions microbiota, responses, influences is for improving treatments
Language: Английский
Citations
0
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 24, 2025
Visceral fat accumulation and dyslipidaemia are associated with infertility symptoms. The cardiometabolic index (CMI) is a comprehensive quantitative measure of central obesity dyslipidaemia. However, the link between female CMI couple needs to be explored further. Hence, this study aimed dissect connection. used cross-sectional approach select 1,641 participants from National Health Nutrition Examination Survey (NHANES), which was conducted 2013 2020. natural log-transformed (In-CMI) consider non-normal distribution CMI. Logistic regression models adjusted for covariates were employed investigate association In-CMI infertility. After adjusting all covariates, each 1 unit increase in 34% incidence (odds ratio [OR] 1.34, 95% confidence interval [CI] 1.10-1.64, p = 0.004). In addition, remained statistically significant after dividing into tertiles (T1, T2, T3). T3 group, highest In-CMI, showed higher odds compared T1 group (OR 2.11, CI 1.38-3.23, < 0.001). Subgroup interaction analyses revealed that depended on history treatment pelvic infection (P <0.05). inflection point positive linear was-0.73. linked Moreover, shows medical significance assessing risk childbearing age.
Language: Английский
Citations
0
Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown
Published: March 9, 2025
The microbiome is crucial for many physiological processes, including immunity, metabolism, and reproduction. This review aims to contribute a detailed understanding of the genital tract, which can lead better management dysbiosis reproductive disorders. Data from four international information databases Medline, Scopus, Embase, Google Scholar. search strategy was based on combination following terms: "microbiota," "microbiome," "microfilm," "microflora," "fertility," or "infertility." advent next-generation sequencing-based technologies during last decade has revealed presence microbial communities in nearly every part human body, system. Several studies have shown significant differences between microbiota vagina endometrium, as well other parts upper tract. plays critical role determining person's health state, tract may impact fertility potential before after assisted treatments (ARTs). To completely understand microbiome, future research should focus not only description but also interaction bacteria, production biofilms, microorganisms with cells.
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Infertility is a widespread medical condition, affecting notable percentage of couples globally, with rising prevalence in India. While assisted reproductive technologies (ART) provide hope, recurrent implantation failure (RIF) continues to challenge approximately one 10 undergoing in-vitro fertilization (IVF). This expert opinion document intends highlight the promise probiotics, particularly from Lactobacillus, as therapeutic approach for improving fertility and treating RIF. In India, on June 29-30, 2024, physical meeting was organized involving 14 specialists gynecology, obstetrics, fields. The role probiotics health discussed an emphasis infertility All experts agree that microbial dysbiosis characterized by imbalance among dominant Lactobacillus species associated RIF leading increased inflammation hence poor outcomes. Probiotics have emerged possible therapies restore equilibrium while reducing enhancing intactness genital epithelium barrier. strongly supported use Lactobacillus-based oral probiotic supplementation preventing miscarriages maintaining pregnancy. unanimously agreed supplementation, Lactobacillus-based, should be considered potential method prevent aid They recommend prior embryo transfer enhance pregnancy rates. emphasizes value safe non-invasive By fostering balanced microbiome, may increase likelihood successful pregnancies.
Language: Английский
Citations
0
Published: March 25, 2025
Infertility is the inability to conceive even after unprotected intercourse for more than 12 months. In India, prevalence of infertility has been growing extent that 10-15 percent couples experience this condition. Recurrent implantation failure (RIF) a complex medical condition in which becomes unsuccessful despite advancements Assisted Reproductive Technologies (ART). We lack clear understanding definition and standardisation RIF protocols. The etiology behind multifactorial, comprising both maternal embryonic factors. Maternal factors include endometrial abnormalities, environmental exposure, physical aspects, dysregulation immune system. Chromosomal aberrations such as aneuploidy are embryo-born impede implantation. latest studies have shed light on novel mechanisms RIF. Recent research identified miRNA can hinder processes, opening door many avenues targeted therapies, gene knockdown, modulation. This review comprehensive overview history, causes, advancements, challenges related
Language: Английский
Citations
0
Ginekologia Polska, Journal Year: 2024, Volume and Issue: 95(4), P. 266 - 275
Published: Feb. 9, 2024
Recurrent miscarriage, poses a significant challenge for many couples globally, the causes of which are not fully understood. Recent studies have shown intricate link between uterine inflammation and recurrent miscarriages. While is essential during early pregnancy stages, especially in embryo implantation, an imbalance can lead to miscarriage. Key inflammatory mediators immune cells significantly alter contribute Lifestyle factors like smoking obesity exacerbate responses, increasing miscarriage risks. Understanding interaction environment, cell imbalances, miscarriages devising effective treatments. This paper presents latest data on inflammation's role emphasizing significance diagnosing chronic endometritis offering practical recommendations treatment diagnosis.
Language: Английский
Citations
3
Obstetrics Gynecology and Reproduction, Journal Year: 2025, Volume and Issue: unknown
Published: March 14, 2025
Infertility is a high-priority medical and social issue, which prevalence reaches 15 %according to the World Health Organization. One of methods for infertility treatment, often resorted by sub-fertile couples, use assisted reproductive technologies (ART). It known that microbiome uterine cavity vagina can affect ART-related fertility potential. The normal vaginal characterized dominance Lactobacillus spp . representatives, ensure maintenance optimal pH values prevent pathogenic microbial penetration multiplication. assumed endometrial predominance ., but relevant studies are prominently heterogeneous. According current hypothesis, and, particularly, crispatus , in associated with favorable outcomes ART programs. Recurrent implantation failures related spreading opportunistic microflora such niches. Nevertheless, some authors have reported no direct correlation between level, presence microorganisms programs, underlies need conduct further large-scale studies.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 30, 2024
This study aims to understand the association between body roundness index (BRI) and female infertility prevalence. Infertility is a public health concern with significant implications for individuals' well-being rights.
Language: Английский
Citations
2
Experimental and Therapeutic Medicine, Journal Year: 2023, Volume and Issue: 26(3)
Published: Aug. 3, 2023
At present, there are currently no reliable and consistent conclusions regarding transvaginal ultrasound assessment of endometrial receptivity in predicting clinical pregnancy outcomes vitro fertilization-embryo transfer (IVF-ET). Thus, the present study, a meta-analysis was performed on multiple indices detected by vaginal ultrasound, aiming to provide diagnostic basis for practice. PubMed, Embase, Cochrane Library databases were searched studies published between establishment through January 2023. Studies that reported infertile women undergoing IVF-ET included, but repeat publication, where full text not obtainable, incomplete information provided or data extraction possible, animals, case reports, reviews, systematic reviews excluded. STATA 15.1 used analyze data. The pooled results showed thickness [Weighted mean difference (WMD)=0.03, 95% CI: 0.00-0.06; P=0.022] volume (WMD=0.41, 0.07-0.74; P=0.017) group after receiving all significantly higher than non-pregnancy group. also vascularization index (VI) (WMD=0.79, 0.56-1.03; P=0.000), flow (FI) (WMD=1.82, 0.83-2.81; P=0.000) (VFI) (WMD=1.58, 0.91-2.24; Systolic/diastolic (S/D) (WMD=-4.92, 95%CI: -8.28- -1.56; P=0.004) uterine artery lower However, differences resistance (RI) pulsatility (PI) vs. statistically significant. Vaginal can be predict measuring endometrium, combined with S/D, VI, FI, VFI artery.
Language: Английский
Citations
5