Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3867 - 3867

Published: April 19, 2025

Medicinal plants, recognized as significant natural resources, have gained prominence in response to the increasing global demand for herbal medicines, necessitating large-scale production of these plants and their derivatives. are exposed a variety internal external factors that interact influence biosynthesis accumulation secondary metabolites. With rapid development omics technologies such genomics, transcriptomics, proteomics, metabolomics, multi-omics become important tools revealing complexity functionality organisms. They conducive further uncovering biological activities metabolites medicinal clarifying molecular mechanisms underlying Also, artificial intelligence (AI) technology accelerates comprehensive utilization high-dimensional datasets offers transformative potential analysis. However, there is currently no systematic review summarizing genomic metabolite plants. Safflower (Carthamus tinctorius L.) has rich diverse bioactive flavonoids, among which Hydroxysafflor yellow A (HSYA) specific safflower emerging medication treating wide range diseases. Hence, progress been made study an excellent example regulation recent years. Here, we on understanding main at level, summarize various types contents, with particular focus flavonoids. This aims provide insight into regulatory from perspective genomics.

Language: Английский

Widely targeted metabolomic, transcriptomic and network pharmacology approach reveals the differences in non-volatile and volatile metabolites and health-promoting functions in the three durian fruits

Journal of Future Foods, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Metabolomics and transcriptomics indicate the changes in medicinal components of Amygdalus mongolica kernels during different developmental stages

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: May 23, 2025

Amygdalus mongolica is a traditional Chinese and Mongolian medicine quite effective in relieving cough eliminating phlegm. In this study, ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) was used to perform metabolomics analysis, combined with transcriptomic sequencing, study the samples of A. at early, middle late growth stages. A comprehensive analysis conducted systematically investigate dynamic changes developmental trajectories kernel progression across distinct stages, utilizing differential expression pathway enrichment approaches. total 104 significant metabolites were identified different stages: early stage (E), (M), (L). Specifically, 68 36 detected comparisons E vs. M L, respectively. Among them, 29 21 exhibiting up-regulation. comparison, 39 15 demonstrated down-regulation. Transcriptomic 133 differentially expressed genes associated 62 pathways M. Simultaneously, 14 linked 13 L. The accumulation various varied marked increase amino acids during phases, alongside fluctuations levels flavonoid compounds. conclusion, reveals variations content types acid compounds key within relevant kernels throughout Especially, compound advancing stages highlights their substantial medicinal potential. These findings provide foundation for future developing valuable ingredients kernels.

Language: Английский