Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(9), P. 388 - 388
Published: Aug. 28, 2024
The
rapid
evolution
of
drug
resistance
is
one
the
greatest
health
issues
21st
century.
There
an
alarming
situation
to
find
new
therapeutic
strategies
or
candidate
drugs
tackle
ongoing
multi-drug
development.
marine
environment
prime
natural
ecosystems
on
Earth,
majority
which
still
unexplored,
especially
when
it
comes
microbes.
A
wide
variety
bioactive
compounds
have
been
obtained
from
a
varied
range
organisms;
however,
bacteria-produced
bacteriocins
are
undermined.
Owing
distinct
environmental
stresses
that
bacterial
communities
encounter,
their
frequently
undergo
adaptations
confer
them
shapes
and
functions,
setting
apart
terrestrial
counterparts.
Bacterially
produced
ribosomally
synthesized
posttranslationally
modified
peptides
(RiPPs),
known
as
bacteriocins,
special
interests
be
considered
alternative
conventional
antibiotics
because
in
structure
diverse
potential
biological
activities.
Additionally,
gut
microbiome
creatures
largely
unexplored
source
with
promising
huge
possibility
novel
might
come
out
efficient
candidates
fight
against
antibiotic
resistance,
light
growing
pressure
antibiotic-resistant
diseases
industrial
desire
for
innovative
treatments.
present
review
summarizes
fully
characterized
evolutionary
aspects,
challenges,
possibilities
ecosystems.
Abstract
The
great
majority
of
microorganisms
are
as‐yet‐uncultivated,
mostly
found
in
extreme
environments.
High‐throughput
sequencing
provides
data‐rich
genomes
from
single‐cell
and
metagenomic
techniques,
which
has
enabled
researchers
to
obtain
a
glimpse
the
unexpected
genetic
diversity
“microbial
dark
matter.”
However,
cultivating
environments
remains
essential
for
dissecting
utilizing
functions
extremophiles.
Here,
we
provide
straightforward
protocol
efficiently
isolating
prokaryotic
different
habitats
(thermal,
xeric,
saline,
alkaline,
acidic,
cryogenic
environments),
was
established
through
previous
successful
work
our
long‐term
experience
extremophile
resource
mining.
We
propose
common
processes
isolation
at
first
then
summarize
multiple
cultivation
strategies
recovering
meanwhile
specific
tips
that
always
overlooked
but
important.
Furthermore,
use
multi‐omics‐guided
microbial
approaches
culturing
these
as‐yet‐uncultivated
two
examples
provided
introduce
how
work.
In
summary,
allows
significantly
improve
efficiency
pure
cultures
novel
taxa,
therefore
paves
way
protection
utilization
resources
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 1, 2023
Methane
is
a
potent
greenhouse
gas,
which
likely
enabled
the
evolution
of
life
by
keeping
early
Earth
warm.
Here,
we
demonstrate
routes
towards
abiotic
methane
and
ethane
formation
under
early-earth
conditions
from
methylated
sulfur
nitrogen
compounds
with
prebiotic
origin.
These
are
demethylated
in
Fenton
reactions
governed
ferrous
iron
reactive
oxygen
species
(ROS)
produced
light
heat
aqueous
environments.
After
emergence
life,
this
phenomenon
would
have
greatly
intensified
anoxic
Archean
providing
substrates.
This
ROS-driven
chemistry
can
occur
delocalized
serpentinization
across
Earth's
humid
realm
thereby
substantially
differs
previously
suggested
that
spatially
restricted.
report
driven
release
might
shaped
chemical
atmosphere
prior
to
origin
beyond.
Abstract
Volcanic
eruptions
generate
initially
sterile
materials
where
biological
processes
are
absent,
allowing
for
the
fresh
colonization
by
new
organisms.
This
review
summarizes
characteristics
of
volcanic
habitats
that
available
pioneer
microbial
colonization,
including
hot
springs,
fumaroles,
lava
tubes,
and
recently
cooled
rock
surfaces
interiors.
Eruptions
provide
unique
insight
into
community
development
in
extreme
environments.
The
trajectories
these
ecosystems
follow
largely
dictated
initial
environmental
conditions
identities
colonizers,
rather
than
age
system.
also
discusses
how
studies
communities
young
flow
fields
can
insights
possibility
life
on
Mars,
which
was
volcanically
hydrologically
active
past.
Understanding
biosignature
preservation
as
well
metabolisms
survival
mechanisms
microorganisms
systems
has
implications
an
ecosystem
might
have
developed
early
Earth
possibly
Mars.
