The role and diagnostics of miR-181d-5p in polycystic ovary syndrome in insulin-resistant women DOI Creative Commons

Min Sang,

Ying Yu, Yaqi Zhang

et al.

Endokrynologia Polska, Journal Year: 2024, Volume and Issue: 75(6), P. 655 - 664

Published: Dec. 30, 2024

To promote the research progress of polycystic ovary syndrome (PCOS), this study analysed role micro RNA (miRNA) in PCOS, to provide new ideas for development PCOS. A total 101 PCOS patients and 95 healthy controls (HC) were enrolled study, according body mass index (BMI), subjects divided into overweight (ow) non-overweight (non-ow), analyses performed compare statistical differences clinically related indexes each group. Serum miR-181d-5p expression was determined by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), diagnostic capability ow non-ow evaluated receiver operating characteristic curve (ROC). The effect on combined with insulin resistance (PCOS-IR) multivariate logistic regression. effects KGN cells under (IR) proliferation apoptosis experiments. In both populations, higher than HC. can be a better aid diagnosis non-ow. used as risk predictor PCOS-IR (p = 0.014). It highly expressed had high predictive ability [area (AUC): 0.898] specificity (83.33%) sensitivity (82.93%) assisting PCOS-IR. IR-inhibited proliferated induced cells, which improved downregulation. This proposed first time, providing reference improving

Language: Английский

The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults DOI Creative Commons
Dawei Wang, Feng Shi, Dingguo Zhang

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 4, 2025

Objective To investigate the association between atherogenic index of plasma (AIP) and risk incident kidney stones.

Language: Английский

Citations

0
Association between waist-to-height ratio and insulin resistance in patients with polycystic ovary syndrome: a meta-analysis DOI Creative Commons
Yuliang Lan, Chunjiu Zhong,

D Li

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Background Insulin resistance (IR) is regarded as a significant role in the pathophysiology of Polycystic Ovary Syndrome (PCOS), hence early identification IR PCOS patients crucial for their treatment. Recent researches indicate that Waist-to-Height Ratio (WHtR) differs with accompanied by compared to those alone; however, consensus has yet be reached. This research presents meta-analysis current data propose straightforward new index diagnosing insulin resistance. Objective study aims assess correlation between WHtR and individuals polycystic ovarian syndrome synthesis information. will offer prognostic insights into onset ovaries. Methods systematic review finalized registration (CRD42025638798) on PROSPERO platform. We conducted search prominent databases, including PubMed, Embase, Web Science, The Cochrane Library, performed manual searches. Observational studies relevance (cohort, case-control, or cross-sectional) published before January 13, 2025, were considered. methodological quality case-control cohort was evaluated using NOS tool. Simultaneously, AHRQ criteria employed evaluate cross-sectional research. outcomes reported mean ± sd. aggregated analyzed StataMP17.0. Results A encompassing nine 3012 participants identified an increased (SMD: 1.07, 95% CI: 0.81, 1.32, p = 0.000). Conclusion Patients exhibit greater without Thus, incidence ovary can anticipated monitoring WHtR. Systematic https://www.crd.york.ac.uk/PROSPERO/view/CRD42025638798 , identifier CRD42025638798.

Language: Английский

Citations

0
New concepts in the roles of AMPK in adipocyte stem cell biology DOI Creative Commons
Alice Pollard

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: 68(3), P. 349 - 361

Published: Aug. 23, 2024

Abstract Obesity is a major risk factor for many life-threatening diseases. Adipose tissue dysfunction emerging as driving in the transition from excess adiposity to comorbidities such metabolic-associated fatty liver disease, cardiovascular Type 2 diabetes and cancer. However, healthy adipose expansion development of these conditions poorly understood. stem cells, residing vasculature stromal regions subcutaneous visceral depots, are responsible maintenance organ function, now recognised key mediators pathological transformation. Impaired drives inflammation, dysregulation endocrine function deposition lipids liver, muscle around vital organs, where it toxic. Contrary previous hypotheses, promotion not inhibition adipogenesis, that presents most attractive therapeutic strategy treatment metabolic disease. AMP-activated protein kinase, master regulator energy homeostasis, has been regarded one target, due its central role lipid metabolism, apparent adipogenesis. recent studies utilising kinase (AMPK)-specific compounds highlight more subtle, time-dependent AMPK process previously unexplored repression leptin, independent adipocyte maturity. In this article, I discuss historic evidence AMPK-mediated adipogenesis multi-faceted roles tissue.

Language: Английский

Citations

3
Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 DOI Creative Commons
Miao Sun,

Shuang Bao

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 29, 2024

It is crucial to identify biomarkers that influence the aging process and associated health risks, given growing severity of global population issue. The objectives our research were evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk accelerated biological assess its use in guiding preventive strategies aging-related risks.

Language: Английский

Citations

1
Die neue PCOS-Leitlinie – Kernaussagen für Diagnostik, Risikobewertung und Lebensstilinterventionen DOI

Katharina Hancke

Die Gynäkologie, Journal Year: 2024, Volume and Issue: 57(9), P. 599 - 605

Published: Aug. 13, 2024

Citations

0
Association between cardiometabolic index and female infertility: a cross-sectional analysis DOI
Yiran Zhao,

Weihui Shi,

Yang Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Background Adverse lipid profile leads to female infertility. The correlation between the cardiometabolic index (CMI) and infertility merits further investigation. Methods data for this study were acquired from 2013–2020 National Health Nutrition Examination Survey (NHANES), with 2333 women enrolled. of each participant was calculated as ratio triglycerides high-density lipoprotein cholesterol multiplied by waist-to-height ratio. Weighted multivariate logistic regression models used assess independent association log-transformed CMI Subgroup analyses carried out reliability findings. Interaction tests employed find if variables affected interacting log CMI. Results A total participants aged 18–45 years enrolled, 274 whom infertile. Log group significantly higher than that non-infertility (P < 0.001). After adjustment potential confounders, more prevalent (OR = 2.411, 95% CI: 1.416–4.112), still consistent in subgroups under 35 Furthermore, restricted cubic spline analysis showed a positive non-linear relationship Conclusions Cardiometabolic levels positively associated increased risk American females. Our demonstrated predictive capacity infertility; nevertheless, additional clarification is required establish direct infertility, which will serve foundation future efforts prevent

Language: Английский

Citations

0
Die neue PCOS-Leitlinie – Kernaussagen für Diagnostik, Risikobewertung und Lebensstilinterventionen DOI

Katharina Hancke

Gynäkologische Endokrinologie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Citations

0
Correlation between cardiometabolic index and female infertility: a cross-sectional analysis DOI Creative Commons
Yiran Zhao,

Weihui Shi,

Yang Liu

et al.

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

Obesity and adverse lipid profile leads to female infertility. The cardiometabolic index (CMI) is a promising indicator for predicting obesity-related diseases. correlation between CMI infertility merits further investigation. data this study were acquired from the 2013–2020 National Health Nutrition Examination Survey (NHANES), with 2333 women enrolled. of each participant was calculated as ratio triglycerides high-density lipoprotein cholesterol multiplied by waist-to-height ratio. Weighted multivariate logistic regression models used assess independent log-transformed Subgroup analyses carried out reliability findings. Interaction tests employed determine whether variables affected interacting log CMI. A total participants aged 18–45 years enrolled, 274 whom infertile. Log group significantly higher than that non-infertility (P < 0.001). After adjustment potential confounders, at an increased risk (OR = 2.411, 95% CI: 1.416–4.112), still consistent in subgroups under 35 Furthermore, restricted cubic spline analysis showed positive non-linear relationship Cardiometabolic levels are positively correlated American females. Our demonstrates predictive capacity

Language: Английский

Citations

0
The role and diagnostics of miR-181d-5p in polycystic ovary syndrome in insulin-resistant women DOI Creative Commons

Min Sang,

Ying Yu, Yaqi Zhang

et al.

Endokrynologia Polska, Journal Year: 2024, Volume and Issue: 75(6), P. 655 - 664

Published: Dec. 30, 2024

To promote the research progress of polycystic ovary syndrome (PCOS), this study analysed role micro RNA (miRNA) in PCOS, to provide new ideas for development PCOS. A total 101 PCOS patients and 95 healthy controls (HC) were enrolled study, according body mass index (BMI), subjects divided into overweight (ow) non-overweight (non-ow), analyses performed compare statistical differences clinically related indexes each group. Serum miR-181d-5p expression was determined by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), diagnostic capability ow non-ow evaluated receiver operating characteristic curve (ROC). The effect on combined with insulin resistance (PCOS-IR) multivariate logistic regression. effects KGN cells under (IR) proliferation apoptosis experiments. In both populations, higher than HC. can be a better aid diagnosis non-ow. used as risk predictor PCOS-IR (p = 0.014). It highly expressed had high predictive ability [area (AUC): 0.898] specificity (83.33%) sensitivity (82.93%) assisting PCOS-IR. IR-inhibited proliferated induced cells, which improved downregulation. This proposed first time, providing reference improving

Language: Английский

Citations

0