Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies
Cells,
Journal Year:
2024,
Volume and Issue:
13(16), P. 1354 - 1354
Published: Aug. 14, 2024
Autophagy,
an
evolutionarily
conserved
cellular
mechanism
essential
for
maintaining
internal
stability,
plays
a
crucial
function
in
female
reproductive
ability.
In
this
review,
we
discuss
the
complex
interplay
between
autophagy
and
several
facets
of
health,
encompassing
pregnancy,
ovarian
functions,
gynecologic
malignancies,
endometriosis,
infertility.
Existing
research
emphasizes
significance
embryo
implantation,
specifically
endometrium,
highlighting
its
necessity
ensuring
proper
fetal
development.
Although
some
knowledge
has
been
gained,
there
is
still
lack
on
specific
molecular
impacts
quality
oocytes,
growth
follicles,
general
health.
Autophagy
role
maturation,
quality,
development
oocytes.
It
also
involved
aging,
contributing
to
reductions
that
occur
with
age.
This
review
explores
physiological
functions
system,
participation
toxicity,
important
connections
endometrium
embryo.
addition,
study
investigates
possibility
emerging
treatment
approaches
aim
modify
autophagy,
using
both
natural
substances
synthetic
molecules,
improve
fertility
outcomes.
Additionally,
intends
inspire
future
exploration
into
intricate
health
by
reviewing
recent
studies
pinpointing
areas
where
current
lacking.
Subsequent
investigations
should
prioritize
conversion
these
discoveries
practical
uses
medical
field,
which
could
potentially
result
groundbreaking
therapies
infertility
other
difficulties
related
reproduction.
Therefore,
gaining
comprehensive
understanding
many
effects
would
not
only
further
field
biology
but
open
new
possibilities
diagnostic
methods.
Language: Английский
The Role of Hypoxia-Inducible Factor-1α (HIF-1α) in the Progression of Ovarian Cancer: Perspectives on Female Infertility
Cells,
Journal Year:
2025,
Volume and Issue:
14(6), P. 437 - 437
Published: March 14, 2025
Hypoxia-Inducible
Factor-1α
(HIF-1α)
is
crucial
in
the
progression
of
ovarian
cancer,
especially
influencing
its
tumor
microenvironment
and
promoting
pathogenic
pathways
that
worsen
female
infertility.
In
hypoxic
settings,
HIF-1α
stabilized
activates
transcription
genes
associated
with
angiogenesis,
metabolic
reprogramming,
epithelial-to-mesenchymal
transition,
therapeutic
resistance.
Angiogenesis
glycolytic
reprogramming
mediated
by
HIF-1
proliferation,
survival,
metastasis.
Its
dysfunction
concurrently
impairs
homeostasis,
undermining
follicular
growth,
hormone
synthesis,
vascular
network,
consequently
contributing
to
Moreover,
induces
persistent
inflammation
oxidative
stress,
an
environment
damaging
reproductive
health.
Due
dual
function
cancer
growth
infertility,
a
potential
target.
Strategies
including
small
molecule
inhibitors
nanoparticle-mediated
delivery
drugs
possess
reduce
activity,
hence
reducing
while
protecting
fertility.
This
review
seeks
clarify
molecular
basis
effects
on
providing
insights
into
novel
treatment
approaches
target
both
controlling
disease
preserving
Language: Английский