Current advances in niosomes applications for drug delivery and cancer treatment

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100837 - 100837

Published: Oct. 21, 2023

The advent of nanotechnology has led to an increased interest in nanocarriers as a drug delivery system that is efficient and safe. There have been many studies addressing nano-scale vesicular systems such liposomes niosome newer generation nanocarriers. niosomes provide multilamellar carrier for lipophilic hydrophilic bioactive substances the self-assembled vesicle, which are composed non-ionic surfactants conjunction with cholesterol or other amphiphilic molecules. These surfactant vesicles, simply known niosomes, can be utilized wide variety technological applications. As alternative liposomes, considered more chemically physically stable. methods preparing economic. Many reports discussed terms their physicochemical properties applications systems. carriers, nano-sized expand horizons pharmacokinetics, decreasing toxicity, enhancing solvability bioavailability. In this review, we review components fabrication well functionalization, characterization, administration routes, cancer gene delivery, natural product delivery. We also discuss limitations challenges development future perspective niosomes.

Language: Английский

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Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 223 - 223

Published: Feb. 4, 2024

Niosomes are vesicular nanocarriers, biodegradable, relatively non-toxic, stable, and inexpensive, that provide an alternative for lipid-solid carriers (e.g., liposomes). may resolve issues related to the instability, fast degradation, bioavailability, insolubility of different drugs or natural compounds. can be very efficient potential systems specific delivery anticancer, antioxidant, anti-inflammatory, antimicrobial, antibacterial molecules. This review aims present overview their composition, most common formulation techniques, as well recent utilizations in cancer therapy.

Language: Английский

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Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies

Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 302 - 302

Published: April 27, 2024

Metformin, a widely used anti-diabetic drug, has garnered attention for its potential in cancer management, particularly breast and colorectal cancer. It is established that metformin reduces mitochondrial respiration, but specific molecular targets within mitochondria vary. Proposed mechanisms include inhibiting respiratory chain Complex I and/or IV, glycerophosphate dehydrogenase, among others. These actions lead to cellular energy deficits, redox state changes, several changes reduce hyperglycemia type 2 diabetic patients. Clinical evidence supports metformin’s role prevention diabetes mellitus Moreover, these patients with cancer, consumption leads an improvement survival outcomes prognosis. The synergistic effects of chemotherapy immunotherapy highlights as adjunctive therapy However, nuanced findings underscore the need further research stratification by subtype, This comprehensive review integrates metformin-related from epidemiological, clinical, preclinical studies Here, we discuss current addressed define bioavailability efficacy, exploring novel metformin-based compounds drug delivery systems, including derivatives targeting mitochondria, combination therapies, nanoformulations, showing enhanced anticancer effects.

Language: Английский

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Codelivery of methotrexate and silibinin by niosome nanoparticles for enhanced chemotherapy of CT26 colon cancer cells

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 055015 - 055015

Published: July 2, 2024

Abstract Colon cancer (CC) is one of the most prevalent cancers in world, and chemotherapy widely applied to combat it. However, drugs have severe side effects emergence multi drug resistance (MDR) common. This bottleneck can be overcome by niosome nanocarriers that minimize dose/toxicity meanwhile allow co-loading incompatible for combination therapy. In this research, silibinin (Sil) as a hydrophobic was loaded into lipophilic part, methotrexate (MTX) hydrophilic part thin film hydration (TFH) method form Nio@MS NPs CT26 colon therapy vitro . Our results indicated synthesis ideal nanoparticles (NPs) with spherical morphology, size ∼100 nm, zeta potential −10 mV. The IC 50 value determined ∼2.6 µg ml −1 , which significantly lower than MTX-Sil (∼6.86 ), Sil (18.46 MTX (9.8 ). Further, reduced cell adhesion density, promoted apoptosis increased gene expression level caspase 3 BAX while significant downregulation BCL2. conclusion, design application co-administer increase cytotoxicity, reduce their dose improve anti-cancer combating MDR.

Language: Английский

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Niosomes containing paclitaxel and gold nanoparticles with different coating agents for efficient chemo/photothermal therapy of breast cancer

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(3), P. 035015 - 035015

Published: Feb. 29, 2024

Breast cancer (BC) is one of the most common cancers in women, and chemotherapy usually used to overcome this cancer. To improve drug delivery sites reduce their side effects, nanocarriers such as niosomes (NIOs) are used. Moreover, a combination other therapeutic methods like photothermal therapy (PTT) can help enhance effect. The aim research design nanocarrier that simultaneously delivers PTT agents. achieve goal, NIOs containing paclitaxel (PTX) chemotherapeutic agent spherical gold nanoparticles (AuNPs) coated with citrate, chitosan (CS), polyamidoamine (PAMAM) were synthesized by thin hydration methods. Their physicochemical properties determined dynamic light scattering, UV-Vis, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) analysis. Cellular uptake, cell cytotoxicity, hyperthermia, apoptosis effects proposed system investigated MCF-7 BC line. cellular uptake NIOs/AuNPs-PAMAM (99.21%) NIOs/AuNPs-CS (98.93%) cells was higher than NIOs/AuNPs (79.55%), demonstrating surface charge plays key role NPs. MTT assay showed viability 45.48% for NIOs/AuNPs/PTX, 34.24% NIOs/AuNPs-CS/PTX, 37.67% NIOs/AuNPs-PAMAM/PTX after 48 h treatment. However, application hyperthermia significantly decreased treated NIOs/AuNPs/PTX (37.72%), NIOs/AuNPs-CS/PTX (10.49%), (4.1%) h. rate high (53.24%) (55.4%) confirming data from MTT. In conclusion, result revealed combined increased cytotoxicity against cells, AuNPs various coating agents affected which be considered efficient therapy.

Language: Английский

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Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 464 - 464

Published: April 2, 2025

Natural substances, especially those derived from plants, exhibit a diverse range of therapeutic benefits, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Nevertheless, their use in clinical settings is frequently impeded by inadequate solubility, limited bioavailability, instability. Nanovesicular carriers, liposomes, niosomes, ethosomes, transferosomes, transethosomes, cubosomes, have emerged innovative phytochemical delivery systems to address these limitations. This review highlights recent developments vesicular nanocarriers for delivery, emphasizing preparation techniques, composition, applications, the future potential systems. Phytosomes, along with key advantages various are extensively described. Various vitro vivo characterization techniques utilized evaluating nanovesicular carriers summarized. Completed trials patents granted nanovesicles encapsulating phytochemicals designed systemic tabulated. Phytochemical via faces challenges low stability, active loading, scalability issues, high production costs. Additionally, immune clearance regulatory hurdles hinder application, requiring improved carrier design formulation techniques.

Language: Английский

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Targeted delivery of silibinin via magnetic niosomal nanoparticles: potential application in treatment of colon cancer cells

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Introduction: In recent years, various nanoparticles (NPs) have been discovered and synthesized for the targeted therapy of cancer cells. Targeted delivery increases local concentration therapeutics minimizes side effects. Therefore, NPs-mediated drug systems become a promising approach treatment cancers. As result, in current study, we aimed to design silibinin-loaded magnetic niosomes (MNNPs) investigate their cytotoxicity property colorectal cell treatment. Methods: MNPs ferrofluids were prepared encapsulated into (NIOs) by thin film hydration method. Afterward, morphology, size, chemical structure MNNPs evaluated using TEM, DLS, FT-IR techniques, respectively. Results Discussion: The distribution number was obtained at about 50 nm 70 with surface charge -19.0 mV TEM DLS analysis, Silibinin loading efficiency NIOs 90%, release pattern showed controlled maximum amount 49% 70%, within 4 h pH = 7.4 5.8, To effect, HT-29 cells treated drugs 24 48 MTT as well flow cytometry assays. Obtained results demonstrated promoted (5-fold decrease viability) compared pure silibinin (3-fold while had no significant cytotoxic effect on HEK-293 (normal line) cells, cellular uptake level line enhanced control group. conclusion, complex can be considered an efficient

Language: Английский

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Fabricating niosomal-PEG nanoparticles co-loaded with metformin and silibinin for effective treatment of human lung cancer cells

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Aug. 17, 2023

Background Despite current therapies, lung cancer remains a global issue and requires the creation of novel treatment methods. Recent research has shown that biguanides such as metformin (MET) silibinin (SIL) have potential anticancer effect. As consequence, effectiveness MET SIL in combination against cells was investigated this study to develop an effective method. Methods Niosomal nanoparticles were synthesized via thin-film hydration method, field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FTIR), atomic force (AFM), dynamic light scattering (DLS) techniques used evaluate their physico-chemical characteristics. The cytotoxic effects free drug-loaded (NPs), well combination, on A549 assessed using MTT assay. An apoptosis test while under influence medication identify molecular mechanisms behind programmed cell death. With use cycle test, it determined whether pharmaceutical caused stop progressing. Additionally, qRT-PCR technique levels hTERT, BAX, BCL-2 gene expression after 48-h treatment. Results In cytotoxicity assay, growth inhibited by both SIL. Compared individual dramatically synergistically decreased IC50 values cells. Furthermore, produced lower better anti-proliferative effect Real-time PCR results showed hTERT significantly reduced lines treated with compared single treatments (p< 0.001). Conclusion It is anticipated nano-niosomal-formed would improve outcomes therapeutic efficiency

Language: Английский

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Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(48), P. 55201 - 55231

Published: Nov. 23, 2023

The nanomaterial and related toolkit have promising applications for improving human health well-being. Nanobased drug delivery systems use nanoscale materials as carriers to deliver therapeutic agents in a targeted controlled manner, they shown potential address issues associated with conventional systems. They offer benefits treating various illnesses by encapsulating or conjugating biological agents, chemotherapeutic drugs, immunotherapeutic agents. of this technology are vast; however, significant challenges exist overcome such safety issues, toxicity, efficacy, insufficient capacity. This article discusses the latest developments systems, including release mechanisms, material toolkits, design molecules, parameters. concluding section examines limitations provides insights into future possibilities.

Language: Английский

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Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells

DARU Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 32(1), P. 133 - 144

Published: Jan. 3, 2024

Language: Английский

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