The Role of Pyroptosis in the Progression and Targeted Therapeutic Approaches for Urological Malignancies DOI Creative Commons

Wenjie Cheng,

Wei Chen, Ruipeng Jia

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9567 - 9581

Published: Nov. 1, 2024

The prevalence of urological malignancies continues to pose a significant global health challenge, particularly due the poor prognosis associated with advanced stages these diseases. Consequently, there is an urgent need deepen our understanding molecular mechanisms governing development facilitate breakthroughs in diagnosis and treatment. Pyroptosis, novel specific form programmed cell death, plays crucial role regulating inflammatory responses, development, tissue homeostasis, stress responses. Recent research has revealed close association between pyroptosis malignancies. In this paper, we review pathogenesis recent advancements malignancies, elucidate involved its regulation, aim provide new directions for clinical management

Language: Английский

TRIM44 alleviates renal ischemia-reperfusion injury by inhibiting pyroptosis through the NLRP3 pathway DOI
Jinzhuo Ning,

Jinrun Wang,

Xuan Sun

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 178, P. 20 - 31

Published: Jan. 14, 2025

Language: Английский

Citations

0
TRIM27 promotes the Warburg effect and glioblastoma progression via inhibiting the LKB1/AMPK/mTOR axis DOI

Juexian Xiao,

Haitao Luo, Shikai Gui

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(7), P. 3468 - 3482

Published: Jan. 1, 2024

Altered protein ubiquitination is associated with cancer. The novel tripartite motif (TRIM) family of E3 ubiquitin ligases have been reported to play crucial roles in the development, growth, and metastasis various tumors. TRIM member TRIM27 acts as a potential promoter tumor development wide range cancers. However, little known regarding biological features clinical relevance glioblastoma (GBM). Here, we report findings elevated expression GBM tissues cell lines. Further functional analysis showed that deletion inhibited growth both vitro vivo. Furthermore, found promoted cells by enhancing Warburg effect. Additionally, inactivation LKB1/AMPK/mTOR pathway was critical for oncogenic effects GBM. Mechanistically, could directly bind LKB1 promote degradation LKB1, which turn enhanced effect progression. Collectively, these data suggest contributes GNM pathogenesis inhibiting axis may be promising candidate diagnostic therapeutic marker patients

Language: Английский

Citations

2
Tripartite motif family – its role in tumor progression and therapy resistance: a review DOI
Yongqi Zhang, Ying Guan, Shuxiang Wang

et al.

Current Opinion in Oncology, Journal Year: 2024, Volume and Issue: 36(2), P. 102 - 114

Published: Jan. 16, 2024

Purpose of review In this review, we summarized published articles on the role tripartite motif (TRIM) family members in initiation and development human malignancies. Recent findings The ubiquitin-proteasome system (UP-S) plays a critical cellular activities, UP-S dysregulation contributes to tumorigenesis. One key regulators is TRIM protein family, most which are active E3 ubiquitin ligases. proteins for biological functions cancer cells, including migration, invasion, metastasis, therapy resistance. Therefore, it important understand how function at molecular level cells. Summary We provide comprehensive up-to-date overview about TRIMs play progression propose as potential new markers targets overcome failure.

Language: Английский

Citations

0
The Role of Pyroptosis in the Progression and Targeted Therapeutic Approaches for Urological Malignancies DOI Creative Commons

Wenjie Cheng,

Wei Chen, Ruipeng Jia

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9567 - 9581

Published: Nov. 1, 2024

The prevalence of urological malignancies continues to pose a significant global health challenge, particularly due the poor prognosis associated with advanced stages these diseases. Consequently, there is an urgent need deepen our understanding molecular mechanisms governing development facilitate breakthroughs in diagnosis and treatment. Pyroptosis, novel specific form programmed cell death, plays crucial role regulating inflammatory responses, development, tissue homeostasis, stress responses. Recent research has revealed close association between pyroptosis malignancies. In this paper, we review pathogenesis recent advancements malignancies, elucidate involved its regulation, aim provide new directions for clinical management

Language: Английский

Citations

0