Intranasal dupilumab improves responsiveness to steroid in an asthma mouse model

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Feb. 19, 2025

Language: Английский

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Gastrointestinal Cognition: Pain Catastrophizing in Irritable Bowel Syndrome, a Cross‐Sectional Study in Mexico

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

ABSTRACT Introduction and Aims Pain catastrophizing is more common in individuals with irritable bowel syndrome (IBS) than healthy individuals. Despite this, its prevalence impact Latin American populations remain under‐researched. Objective To assess pain differences between IBS patients subjects. Materials Methods Cross‐sectional study which subjects (HC) were recruited from our tertiary care center. diagnosis was established based on the Rome IV criteria. All participants answered scale (PCS), hospital anxiety depression (HAD), severity scoring system (IBS‐SSS). Group comparisons employed Student's t ‐test or Mann–Whitney U test, Pearson's Spearman's for correlations logistic regression to predictors. Results A total of 920 (66.4% women) a median age 23 years (range: 18–60) met inclusion had higher clinically significant compared (22.5% vs. 11%, p < 0.0001). When classified by symptom intensity, 52.2% severe symptoms exhibited catastrophizing, 25.3% moderate 14.7% mild ( Anxiety (OR 2.5, 95% CI 1.9–3.4, 0.0001), 1.7, 1.3–2.3, 2.3, 1.6–3.3, 0.0001) significantly associated IBS. Conclusions In Mexican IBS, gastrointestinal psychological distress. Comprehensive management this population should involve addressing cognitive patterns conjunction conventional treatments.

Language: Английский

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The antidepressant potential of saffron (Crocus sativus L.): molecular mechanisms, neurotransmitter modulation, gut-brain axis interactions, and clinical efficacy in major depressive disorder

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

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Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12318 - 12318

Published: Nov. 16, 2024

The expression of

Language: Английский

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