An environmental isolate of Pseudomonas, 20EI1, reduces Aspergillus flavus growth in an iron-dependent manner and alters secondary metabolism
Elizabeth M. Wyman,
No information about this author
W. Scott Grayburn,
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Matthew K. Gilbert
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et al.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 20, 2025
Introduction
Aspergillus
flavus
is
an
opportunistic
pathogenic
fungus
that
infects
oilseed
crops
worldwide.
When
colonizing
plants,
it
produces
mycotoxins,
including
carcinogenic
compounds
such
as
aflatoxins.
Mycotoxin
contamination
results
in
important
economic
and
health
impact.
The
design
of
new
strategies
to
control
A.
colonization
mycotoxin
paramount.
Methods
biocontrol
potential
a
promising
isolate
Pseudomonas
spp.,
20EI1
against
was
assessed
using
bioassays
microscopy.
To
further
elucidate
the
nature
this
bacterial-fungal
interaction,
we
also
performed
chemical
transcriptomics
analyses.
Results
In
present
study,
able
reduce
growth
.
Furthermore,
determined
inhibition
iron-dependent.
addition,
reduced
or
blocked
production
aflatoxin,
well
cyclopiazonic
acid
kojic
acid.
Expression
iron-related
genes
altered
presence
bacteria
involved
aflatoxin
were
down-regulated.
Iron
supplementation
partially
reestablished
their
expression.
other
secondary
metabolite
(SM)
by
bacteria,
clusters
acid,
imizoquin
biosynthesis,
while
cluster
corresponding
aspergillicin,
siderophore,
upregulated.
Interestingly,
global
SM
regulatory
gene
mtfA
significantly
upregulated
20EI1,
which
could
have
contributed
observed
alterations
SM.
Discussion
Our
suggest
,
provide
insight
into
iron-dependent
interaction
affecting
expression
numerous
genes,
among
them
those
Language: Английский
Exploring the Bioactive Potential of Citrus reticulata Pomace: Extraction, Characterization, and Applications
Food and Humanity,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100518 - 100518
Published: Jan. 1, 2025
Language: Английский
Microbial evaluation of Melaleuca alternifolia essential oil for its antifungal activity against Trichophyton violaceum and its synergistic effects with ITZ and KTZ
Tanzeela Qayyum,
No information about this author
Aroosh Shabbir,
No information about this author
Najeeb Ullah
No information about this author
et al.
Archives of Dermatological Research,
Journal Year:
2025,
Volume and Issue:
317(1)
Published: March 30, 2025
Language: Английский
Evaluation of antioxidant and anti-inflammatory properties, bioactive compound profiling, and molecular mechanisms of a multicomponent Thai herbal formulation
Phytomedicine Plus,
Journal Year:
2024,
Volume and Issue:
4(4), P. 100662 - 100662
Published: Oct. 22, 2024
Language: Английский