Agronomy,
Journal Year:
2024,
Volume and Issue:
15(1), P. 76 - 76
Published: Dec. 30, 2024
A
transformation
is
needed
in
agricultural
production
to
satisfy
the
growing
population-based
increased
food
demands
and
overcome
safety
challenges
while
supporting
human
health
preservation
of
natural
resources.
Improving
sustainable
practices
essential
for
developing
a
long-term
resilient
economy.
This
systematic
review
with
meta-analyses
aims
overview
agriculture’s
progress,
trends,
future
opportunities,
focusing
primarily
on
integrating
novel
technologies
into
recently
prevailing
operations.
As
basis,
an
extensive
literature
search
was
conducted,
identifying
nearly
45,000
records
related
closely
various
dimensions
agriculture.
Out
these,
based
thorough
selection
process,
291
were
included
further
evaluations.
The
temporal
distribution
content
analyses
indicated
improvement
number
papers
spectrum
addressed
aspects.
analysis
publications
revealed
that
most
traditional
farming
focus
mass
cannot
deal
interrelated
sustainability
challenges.
On
other
hand,
consider
sustainability’s
environmental,
economic,
social
aspects,
thereby
preserving
environmental
economic
viability
well-being.
integrative
assessment
this
study
suggests
adopting
novel,
innovative
can
achieve
significant
progress
toward
sustainability.
At
same
time,
broad
range
limitations
are
listed,
which
widely
hinder
penetration
initiatives.
To
eliminate
these
barriers,
consistent
policy
regulations
required,
targeting
specific
problems,
alongside
complex,
education-based
support
system,
boosting
initiatives
green
transition
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: May 20, 2024
Circulating
tumor
cells
(CTCs)
have
significant
clinical
value
in
early
detection,
dynamic
monitoring
and
immunotherapy.
CTC
detection
stands
out
as
a
leading
non-invasive
approach
for
diagnostics
therapeutics.
However,
the
high
heterogeneity
of
CTCs
occurrence
epithelial-mesenchymal
transition
(EMT)
during
metastasis
pose
challenges
to
methods
relying
on
EpCAM-positive
enrichment.
To
address
these
limitations,
method
based
negative
enrichment
using
specific
leukocyte
targets
has
been
developed.
In
this
study,
aiming
overcome
low
purity
associated
with
immunomagnetic
beads
targeting
solely
common
antigen
CD45,
we
introduced
CD66b-modified
beads.
CD66b,
target
neutrophils
abundant
residues,
was
chosen
complementary
approach.
The
process
involved
initial
collection
nucleated
from
whole
blood
samples
density
gradient
centrifugation.
Subsequently,
magnetically
labeled
leukocytes
were
removed
by
magnetic
field,
enabling
capture
higher
sensitivity
while
retaining
their
activity.
Finally,
selected
20
patients
various
cancers
validate
effectiveness
strategy,
providing
new
generalized
tool
CTCs.
Cancer Research,
Journal Year:
2024,
Volume and Issue:
84(17), P. 2888 - 2910
Published: June 11, 2024
Abstract
Colorectal
cancer
is
the
second
most
common
malignant
tumor
worldwide.
Analysis
of
changes
that
occur
during
colorectal
progression
could
provide
insights
into
molecular
mechanisms
driving
development
and
identify
improved
treatment
strategies.
In
this
study,
we
performed
an
integrated
multiomic
analysis
435
trace
samples
from
148
patients
with
cancer,
covering
nontumor,
intraepithelial
neoplasia
(IEN),
infiltration,
advanced
stage
phases.
Proteogenomic
analyses
demonstrated
KRAS
BRAF
mutations
were
mutually
exclusive
elevated
oxidative
phosphorylation
in
IEN
phase.
Chr17q
loss
chr20q
gain
also
exclusive,
which
occurred
predominantly
infiltration
phases,
respectively,
impacted
cell
cycle.
Mutations
TP53
frequent
phase
associated
microenvironment,
including
increased
extracellular
matrix
rigidity
stromal
infiltration.
profiles
based
on
consensus
subtype
intrinsic
classifications
revealed
paths
each
indicated
microsatellite
instability
was
specific
classifications.
Additional
comparison
characteristics
location
showed
ANKRD22
amplification
by
chr10q23.31
enhanced
glycolysis
right-sided
cancer.
The
AOM/DSS-induced
carcinogenesis
mouse
model
DDX5
deletion
due
to
chr17q
promoted
development,
consistent
findings
patient
samples.
Collectively,
study
provides
informative
resource
for
understanding
events
different
stages
identifying
potential
therapeutic
targets.
Significance:
Characterization
proteogenomic
landscape
a
map
detailing
alterations
suggesting
diagnostic
approaches
patients.
World Journal of Surgical Oncology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 30, 2024
Abstract
Background
Peutz–Jeghers
syndrome
(PJS),
a
rare
dominantly
inherited
disease,
is
primarily
characterized
by
hamartomatous
polyps
and
melanotic
macules
as
well
an
increased
risk
of
cancer.
The
current
study
aimed
to
identify
the
pathogenic
gene
mechanism
proband
with
PJS,
thereby
offering
precise
prevention
treatment
strategies
for
PJS.
Methods
A
detailed
clinical
examination
was
performed
diagnosed
PJS
her
family
members.
In
addition,
peripheral
venous
blood
collected
from
members
extract
genomic
DNA.
genes
were
identified
using
whole-exome
sequencing,
candidate
variants
verified
via
Sanger
sequencing.
Meanwhile,
co-segregation
tests
among
six
Finally,
reverse
transcription-polymerase
chain
reaction
(RT-PCR)
assess
transcript
in
cells
patients
non-related
healthy
controls.
Results
Genetic
testing
revealed
splicing
variant
c.921-1G
>
C
STK11
sister
nephew,
co-segregated
affected
nonrelated
phenotypically
presented
gastric-type
adenocarcinoma
cervix.
RT-PCR
that
could
produce
two
transcripts.
Of
note,
40
base
pairs
deleted
aberrant
between
exons
3
4,
resulting
frameshift
premature
termination
amino
acid
exon
6
ultimately
leading
loss
its
functional
domain
protein.
showed
compared
controls,
mRNA
expression
level
<
50%
patients.
Conclusion
present
results
indicated
intron
7
may
be
However,
this
(in
7)
not
abnormal
transcripts
(deletion
4),
attributed
decrease
expression.
Therefore,
emphasized
importance
genetic
counseling,
pre-symptomatic
monitoring,
early
complication
management
OMICS A Journal of Integrative Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
Lung
cancer
remains
one
of
the
leading
causes
cancer-related
deaths
globally,
with
its
complexity
driven
by
intricate
and
intertwined
genetic,
epigenetic,
environmental
factors.
Despite
advances
in
genomics,
transcriptomics,
proteomics,
understanding
phenotypic
diversity
lung
has
lagged
behind.
Next-generation
phenomics,
which
integrates
high-throughput
data
multiomics
approaches
digital
technologies
such
as
artificial
intelligence
(AI),
offers
a
transformative
strategy
for
unraveling
cancer.
This
approach
leverages
advanced
imaging,
single-cell
technologies,
AI
to
capture
dynamic
variations
at
cellular,
tissue,
whole
organism
levels
ways
resolved
temporal
spatial
contexts.
By
mapping
spatially
temporally
profiles
onto
molecular
alterations,
next-generation
phenomics
provides
deeper
insights
into
tumor
microenvironment,
heterogeneity,
drug
efficacy,
safety,
resistance
mechanisms.
Furthermore,
integrating
genomic
proteomic
networks
allows
identification
novel
biomarkers
therapeutic
targets
informed
biological
structure
function,
fostering
precision
medicine
treatment.
expert
review
examines
places
context
current
potential
redefine
diagnosis,
prognosis,
therapy.
It
highlights
emerging
role
machine
learning
analyzing
complex
datasets,
enabling
personalized
interventions.
Ultimately,
holds
promise
bridging
gap
between
alterations
clinical
population
health
outcomes,
providing
holistic
biology
that
could
revolutionize
management
improve
patient
survival
rates.
Agronomy,
Journal Year:
2024,
Volume and Issue:
15(1), P. 76 - 76
Published: Dec. 30, 2024
A
transformation
is
needed
in
agricultural
production
to
satisfy
the
growing
population-based
increased
food
demands
and
overcome
safety
challenges
while
supporting
human
health
preservation
of
natural
resources.
Improving
sustainable
practices
essential
for
developing
a
long-term
resilient
economy.
This
systematic
review
with
meta-analyses
aims
overview
agriculture’s
progress,
trends,
future
opportunities,
focusing
primarily
on
integrating
novel
technologies
into
recently
prevailing
operations.
As
basis,
an
extensive
literature
search
was
conducted,
identifying
nearly
45,000
records
related
closely
various
dimensions
agriculture.
Out
these,
based
thorough
selection
process,
291
were
included
further
evaluations.
The
temporal
distribution
content
analyses
indicated
improvement
number
papers
spectrum
addressed
aspects.
analysis
publications
revealed
that
most
traditional
farming
focus
mass
cannot
deal
interrelated
sustainability
challenges.
On
other
hand,
consider
sustainability’s
environmental,
economic,
social
aspects,
thereby
preserving
environmental
economic
viability
well-being.
integrative
assessment
this
study
suggests
adopting
novel,
innovative
can
achieve
significant
progress
toward
sustainability.
At
same
time,
broad
range
limitations
are
listed,
which
widely
hinder
penetration
initiatives.
To
eliminate
these
barriers,
consistent
policy
regulations
required,
targeting
specific
problems,
alongside
complex,
education-based
support
system,
boosting
initiatives
green
transition
