Cancers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 3076 - 3076
Published: Sept. 4, 2024
The
purpose
of
this
study
was
to
conduct
a
systematic
review
and
meta-analysis
case
reports
presenting
HCC
spread
the
diaphragm
muscle
determine
possible
risk
factors
for
condition.
An
extensive
literature
search
performed
using
following
electronic
databases:
MEDLINE,
CINAHL,
ScienceDirect,
Google
Scholar,
DOAJ.
A
total
18
articles
describing
27
hepatocellular
carcinoma
patients
were
included
in
review.
presence
cells
superior
liver
segment
is
strongly
associated
with
metastases
diaphragm.
Among
two
types
involvement
by
cells,
infiltration
occurs
much
more
frequently
than
adhesion.
However,
an
nodule
8th
higher
number
segments
involved
predispose
Hepatitis
B
factor
recurrent
HCC.
tumor
diameter
not
muscle.
We
did
find
specific
symptoms
reported
that
could
indicate
metastasis
hepatitis
localization
segments,
especially
segment,
should
be
take
into
consideration
diagnostic
process.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 20, 2024
Abstract
Regulatory
T
cells
(Tregs)
expressing
the
transcription
factor
FoxP3
are
essential
for
maintaining
immunological
balance
and
a
significant
component
of
immunosuppressive
tumor
microenvironment
(TME).
Single-cell
RNA
sequencing
(ScRNA-seq)
technology
has
shown
that
Tregs
exhibit
plasticity
functional
diversity
in
various
tumors
within
TME.
This
results
playing
dual
role
TME,
which
is
not
always
centered
around
supporting
progression
as
typically
believed.
Abundant
data
confirms
anti-tumor
activities
their
correlation
with
enhanced
patient
prognosis
specific
types
malignancies.
In
this
review,
we
summarize
potential
actions
Tregs,
including
suppressing
tumor-promoting
inflammatory
responses
boosting
immunity.
addition,
study
outlines
spatial
temporal
variations
function
to
emphasize
predictive
significance
malignancies
may
change.
It
comprehend
effects
improve
therapy
strategies.
Journal of Hepatocellular Carcinoma,
Journal Year:
2025,
Volume and Issue:
Volume 12, P. 169 - 182
Published: Jan. 1, 2025
To
assess
the
activity
and
toxicity
of
hepatic
arterial
infusion
chemotherapy
(HAIC)+tislelizumab+lenvatinib
(HAIC+tisle+len)
in
hepatocellular
carcinoma
(HCC)
with
portal
vein
tumor
thrombus
(PVTT)
type
IV
(Vp4
hCC)
a
real-world
context.
Fifty-five
patients,
Vp4
hCC
receiving
HAIC+tisle+len
therapy
from
April
2021
to
December
2022,
were
analyzed
retrospectively.
Data
on
patient
characteristics,
adverse
events
(AEs),
treatment,
survival
collected.
Outcomes
disease
control
rate
(DCR),
overall
response
(ORR),
(OS),
progression-free
(PFS),
treatment-related
AEs
(TRAEs).
As
20,
2023,
median
follow-up
was
17.5
months
(95%
confidence
interval
[CI]:
14.7-22.5).
The
ORR
52.7%
(3
complete
[CR],
26
partial
[PR])
as
per
RECIST
v1.1
65.5%
(12
CR,
24
PR)
mRECIST.
DCR
94.5%
using
both
PFS
OS
8.0
CI:
6.2-12.3)
16.7
12.0-not
reached),
respectively.
Additionally,
independently
predicted
only
by
best
response.
In
patients
(PR
or
CR),
11.7
8.02-not
reached)
mRECIST
15.4
7.39-not
v1.1.
Hypertension
(14.5%),
decreased
albumin
levels
(10.9%)
anorexia
(9.1%)
most
frequently
observed
grade
3-4
TRAEs.
regimen
demonstrated
promising
efficacy
favorable
safety
for
HCC
Vp4,
providing
valuable
evidence
complement
trial
data
hCC.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 13, 2025
Background
In
cancer
metastasis,
tumor
cells
condition
distant
tissues
to
create
a
supportive
environment,
or
metastatic
niche,
by
driving
the
activation
of
cancer-associated
fibroblasts
(CAFs).
These
CAFs
remodel
extracellular
matrix,
creating
microenvironment
that
supports
growth
and
compromises
immune
cell
function,
enabling
evade
detection.
Consequently,
targeting
has
been
proposed
as
therapeutic
strategy
hinder
spread.
Our
objective
was
develop
first
in
vitro
phenotypic
screening
assay
capable
assessing
this
process.
Methods
Human
primary
lung
were
co-cultured
with
highly
invasive
breast
(MDA-MB-231)
identify
changes
expression
selected
genes
using
RT-qPCR.
An
In-Cell
ELISA
(ICE)-based
human
fibroblasts,
MDA-MB-231
monocytes
(THP-1
cells)
developed
measure
CAFs.
Another
used
released
osteopontin.
Results
When
fibroblast
cells,
among
10
genes,
for
osteopontin
(SPP1),
insulin
like
factor
1
(IGF1),
periostin
(POSTN)
α-smooth
muscle
actin
(α-SMA,
ACTA2)
elicited
greatest
fold
change
(55-,
37-,
8-
5-fold
respectively).
Since
osteopontin,
IGF-1
are
secreted
proteins
α-SMA
is
an
intracellular
cytoskeleton
protein,
chosen
be
readout
biomarker
ICE
assay.
96
well
assay,
increased
2.3-fold
yielding
robust
Z′
0.56.
A
secondary,
low
throughput
measuring
release
which
showed
6-fold
increase
when
monocytes.
Discussion
This
96-well
format,
making
it
suitable
medium-to
high-throughput
potential
compounds.
By
focusing
on
observable
cellular
rather
than
specific
molecular
pathways,
allows
broader
unbiased
identification
compounds
modulating
CAF
activation.
Journal of Hepatocellular Carcinoma,
Journal Year:
2025,
Volume and Issue:
Volume 12, P. 353 - 365
Published: Feb. 1, 2025
Primary
liver
cancer,
predominantly
hepatocellular
carcinoma
(HCC),
constitutes
a
substantial
global
health
challenge,
characterized
by
poor
prognosis,
particularly
in
regions
with
high
prevalence
of
hepatitis
B
virus
(HBV)
infection,
such
as
China.
This
study
sought
to
develop
and
validate
machine
learning-based
prognostic
model
predict
survival
outcomes
patients
HBV-related
HCC
following
radical
resection,
the
potential
inform
personalized
treatment
strategies.
retrospectively
analyzed
clinical
data
from
146
at
Xinjiang
Medical
University
75
The
Cancer
Genome
Atlas
(TCGA)
database.
A
was
developed
using
learning
algorithm
evaluated
for
predictive
performance
concordance
index
(C-index),
calibration
curve,
decision
curve
analysis
(DCA),
receiver
operating
characteristic
(ROC)
curves.
Key
predictors
constructing
best
included
body
mass
(BMI),
albumin
(ALB)
levels,
surgical
resection
method
(SRM),
American
Joint
Committee
on
(AJCC)
stage.
achieved
C-index
0.736
training
set
performed
well
both
validation
datasets.
It
accurately
predicted
1-,
3-,
5-year
rates,
Area
Under
Curve
(AUC)
values
0.843,
0.797,
0.758,
respectively.
Calibration
Decision
Analysis
(DCA)
further
validated
model's
capability,
suggesting
its
use
decision-making.
highlights
importance
BMI,
ALB,
SRM,
AJCC
staging
predicting
outcomes.
aids
clinicians
making
better
decisions,
potentially
enhancing
patient
Journal of Hepatocellular Carcinoma,
Journal Year:
2025,
Volume and Issue:
Volume 12, P. 367 - 382
Published: Feb. 1, 2025
Hepatocellular
carcinoma
(HCC)
is
a
leading
cause
of
cancer-related
mortality
with
challenging
prognosis.
HCC
lacks
effective
prognostic
biomarkers.
We
investigated
the
diagnostic
and
value
COIL
expression
in
HCC.
This
study
evaluated
significance
using
data
from
TCGA
local
hospital
samples,
374
118
liver
cancer
patients
database
hospital,
respectively.
The
techniques
include
bioinformatics
analysis,
qRT-PCR,
immunohistochemistry
(IHC),
vitro
cell
experiments,
which
encompass
CCK-8
assays,
wound
healing
Transwell
invasion
assays.
relationship
between
clinical
outcomes
was
assessed,
COIL's
biological
function
through
cellular
Analysis
lines
tissue
samples
revealed
that
mRNA
or
protein
levels
were
significantly
higher
lines/tissues
compared
to
normal
cells/tissues.
Univariate
multivariate
analyses
indicated
an
independent
factor
for
overall
survival
(OS)
Additionally,
14%
had
alterations
gene,
gene
lower
OS
(p<0.001)
disease-free
(DFS)
those
without
alterations.
Knockdown
inhibited
proliferation,
migration,
Hep3B,
HepG2,
Huh7.
Compared
control
group,
knockdown
cells
showed
marked
reduction
CDC25C
CCNB1
levels,
suggesting
leads
G2/M
phase
cycle
arrest.
After
knockdown,
caspase-3
BCL-2
downregulated,
while
cleaved
caspase
BAX
upregulated,
indicating
promotes
apoptosis
cells.
predictor
association
poor
its
role
enhancing
proliferation
highlight
potential
as
therapeutic
target.
