Clinical Pathologic Profiles of Helicobacter pylori Reveal Age-Specific Peaking with Concomitant Chronic Gastric Inflammation, Robust Immunity, and Tissue Alterations Implying Potential Predisposition to Malignancy in Ha’il, Saudi Arabia DOI Open Access
Kamaleldin B. Said, Khalid Farhan Alshammari, Safia Moussa

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2643 - 2643

Published: April 11, 2025

Background/Objectives: Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic ulcers, and gastric malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarming rates of prevalence. This study aimed elucidate local epidemiological patterns H. examine its histopathological impact on mucosa. Methods: retrospective-cross-sectional included 805 symptomatic adults (329 males, 476 females) who underwent endoscopic evaluation at King Salman Hospital, Ha’il, Saudi Arabia. Biopsies from antrum body were processed using routine formalin fixation paraffin embedding. Staining with hematoxylin–eosin (H&E) Giemsa permitted assessment gastritis detection pylori. Data evaluated by IBM SPSS (version 23, Corp., Armonk, NY) for associations among infection, histopathology, patient characteristics. Results: A total 727 (90.3%) pylori-positive marginally higher females (91.2%) than males (89.0%). Infection spanned all age groups, reaching 100% aged 60–80 years. Overall GI complications identified 726 (99.9%), being most profound histopathologically (19.3%). Lymphoid aggregates 93.0% biopsies reflected pronounced immune response. Advanced lesions, including metaplasia (0.8%), atrophy (0.3%), lymphoma (0.1%), uncommon, though indicative potential malignant progression. Despite both sexes exhibiting universal symptoms dyspepsia, heartburn, there no statistically gender-based differences (p > 0.05); specifically, post-H. signs such as vomiting, nausea, weight loss, bleeding or hematemesis occurred equally all. Histopathology consistently revealed active glandular distortion, lymphoplasmacytic infiltration, occasional mucosal erosions. staining further confirmed abundant spiral shapes underscoring high bacterial load. Conclusion: These findings highlight age-specific persistently elevating significantly associated inflammatory complications. Although advanced lesions remain rare, reflecting regional epidemiology, early screening, sleeve treatment efforts, transformation makes it imperative continued vigorous eradication, therapy, vigilant follow-up avert severe disease outcomes.

Language: Английский

Addressing the global challenge of Helicobacter pylori -induced dyspepsia and peptic ulcer disease: socioeconomic, clinicopathologic, and clinico-pharmacological implications of the new treatment guidelines DOI Creative Commons
Patrick Ashinze, Simran Karkhanis,

Babas Puamus Oki

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: April 1, 2025

Language: Английский

Citations

0
Clinical Pathologic Profiles of Helicobacter pylori Reveal Age-Specific Peaking with Concomitant Chronic Gastric Inflammation, Robust Immunity, and Tissue Alterations Implying Potential Predisposition to Malignancy in Ha’il, Saudi Arabia DOI Open Access
Kamaleldin B. Said, Khalid Farhan Alshammari, Safia Moussa

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2643 - 2643

Published: April 11, 2025

Background/Objectives: Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic ulcers, and gastric malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarming rates of prevalence. This study aimed elucidate local epidemiological patterns H. examine its histopathological impact on mucosa. Methods: retrospective-cross-sectional included 805 symptomatic adults (329 males, 476 females) who underwent endoscopic evaluation at King Salman Hospital, Ha’il, Saudi Arabia. Biopsies from antrum body were processed using routine formalin fixation paraffin embedding. Staining with hematoxylin–eosin (H&E) Giemsa permitted assessment gastritis detection pylori. Data evaluated by IBM SPSS (version 23, Corp., Armonk, NY) for associations among infection, histopathology, patient characteristics. Results: A total 727 (90.3%) pylori-positive marginally higher females (91.2%) than males (89.0%). Infection spanned all age groups, reaching 100% aged 60–80 years. Overall GI complications identified 726 (99.9%), being most profound histopathologically (19.3%). Lymphoid aggregates 93.0% biopsies reflected pronounced immune response. Advanced lesions, including metaplasia (0.8%), atrophy (0.3%), lymphoma (0.1%), uncommon, though indicative potential malignant progression. Despite both sexes exhibiting universal symptoms dyspepsia, heartburn, there no statistically gender-based differences (p > 0.05); specifically, post-H. signs such as vomiting, nausea, weight loss, bleeding or hematemesis occurred equally all. Histopathology consistently revealed active glandular distortion, lymphoplasmacytic infiltration, occasional mucosal erosions. staining further confirmed abundant spiral shapes underscoring high bacterial load. Conclusion: These findings highlight age-specific persistently elevating significantly associated inflammatory complications. Although advanced lesions remain rare, reflecting regional epidemiology, early screening, sleeve treatment efforts, transformation makes it imperative continued vigorous eradication, therapy, vigilant follow-up avert severe disease outcomes.

Language: Английский

Citations

0